宜宾地区汉族人群Sp110基因多态性与肺结核易感性的相关性
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摘要
目的探讨宜宾地区汉族人群Sp110基因多态性与肺结核易感性的相关性。方法选择2011年1月—2012年12月按病例对照研究设计选取112例肺结核患者和140例健康人作为研究对象,比较两组的一般资料,测定其Sp110基因2个SNP位点(rs11679983、rs3948464)的基因型,探索其与肺结核易感性的相关性。结果 (1)观察组和对照组吸烟史(49.1%vs33.6%)和家族结核病史(23.2%vs 9.3%)差异有统计学意义(P<0.05);(2)观察组rs11679983 G等位基因频率(51.8%vs33.6%)、rs3948464 C等位基因频率(92.9%vs 81.4%)高于对照组(P<0.05),其OR分别为2.13和2.97;(3)两组患者rs11679983和rs3948464的基因型分布不一致(P<0.05)。结论 Sp110基因的rs11679983A/G和rs3948464C/T位点多态性可能是该地区汉族人群肺结核易感性的影响因素。
Objective To explore the relationship between Sp110 gene polymorphism and tuberculosis susceptibility of Chinese Han population in Yibin region. Methods One hundred and twelve tuberculosis patients and 140 control patients were selected from January 2011 to December 2012 at the First People's Hospital and Infectious Disease Hospital of Yibin by using case-control study to investigate their normal information and detect 2 SNP sites of Sp110 gene,finally the relationship between Sp110 gene SNPs polymorphism and tuberculosis susceptibility was explored. Results(1) There were significant differences in smoking history(49. 1% vs 33. 6%)and family history(23. 2% vs 9. 3%) of tuberculosis between case group and control group( P < 0. 05).( 2) The frequencies of rs11679983 G allele(51. 8% vs 33. 6%) and rs3948464 C allele( 92. 9% vs 81. 4%) in case group were significantly higher than those in control group with an OR 2. 13 and 2. 97 respectively( P < 0. 05).(3) The genotypes of rs11679983 and rs3948464 were not consistent in two groups( P < 0. 05). Conclusions The polymorphisms of rs11679983 A/G and rs3948464 C/T of Sp110 gene may be the influencing factors of tuberculosis susceptibility of Chinese Han population in Yibin region.
Objective To explore the relationship between Sp110 gene polymorphism and tuberculosis susceptibility of Chinese Han population in Yibin region. Methods One hundred and twelve tuberculosis patients and 140 control patients were selected from January 2011 to December 2012 at the First People's Hospital and Infectious Disease Hospital of Yibin by using case-control study to investigate their normal information and detect 2 SNP sites of Sp110 gene,finally the relationship between Sp110 gene SNPs polymorphism and tuberculosis susceptibility was explored. Results(1) There were significant differences in smoking history(49. 1% vs 33. 6%)and family history(23. 2% vs 9. 3%) of tuberculosis between case group and control group( P < 0. 05).( 2) The frequencies of rs11679983 G allele(51. 8% vs 33. 6%) and rs3948464 C allele( 92. 9% vs 81. 4%) in case group were significantly higher than those in control group with an OR 2. 13 and 2. 97 respectively( P < 0. 05).(3) The genotypes of rs11679983 and rs3948464 were not consistent in two groups( P < 0. 05). Conclusions The polymorphisms of rs11679983 A/G and rs3948464 C/T of Sp110 gene may be the influencing factors of tuberculosis susceptibility of Chinese Han population in Yibin region.
引文
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[4]安雅臣,冯福民,袁聚祥,等.NRAMP1基因INT4和3'UTR位点多态性与肺结核易感性的研究[J].中华流行病学杂志,2006,27(1):37-40.
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[10]周莹,黄迪迪,何丹,等.SP110基因rs11679983A/G多态性与中国南方汉族肺结核易感性研究[J].中华医院感染学杂志,2016,26(7):1477-1479.
[11]周丹,陶杨,蔡家春,等.SP110基因rs1135791、rs722555多态性与结核病的相关性研究[J].现代预防医学,2008,35(3):416-419.
[12]周丹,李革.核体蛋白SP110及其生物学功能[J].医学分子生物学杂志,2006,3(4):271-274.
[13]向颖,林辉,胡代玉,等.SP110和VDR基因多态性与结核病的关联及其与环境因素的交互作用[J].局解手术学杂志,2013,22(4):377-379.
[14]LIANG L,ZHAO YL,YUE J,et al.Association of SP110 gene polymorphisms with susceptibility to tuberculosis in a Chinese population[J].Infect Genet Evol,2011,11(5):934-939.
[15]LI Y,WANG Y,LIU X.The role of airway epithelial cells in response to mycobacteria infection[J].Clin Dev Immunol,2012,2012:791392.
[16]席向宇,张瑞梅,刘慧梅,等.SP110基因多态性与肺结核易感性的关系[J].江苏医药,2017,43(7):480-482.
[2]GOMEZ LM,CAMARGO JF,CASTIBANCO J,et al.Analysis of IL1B,TAP1,TAP2 and IKBL polymorphisms on susceptibility to tuberculosis[J].Tissue Antigens,2006,67(4):290-296.
[3]冯福民,王东,郭梅,等.MBP-52位点多态性与肺结核易感性的病例对照研究[J].现代预防医学,2007,34(3):438-440.
[4]安雅臣,冯福民,袁聚祥,等.NRAMP1基因INT4和3'UTR位点多态性与肺结核易感性的研究[J].中华流行病学杂志,2006,27(1):37-40.
[5]刘玮,张翠英,吴晓明,等.维生素D受体多态性与肺结核易感性的病例对照研究[J].中国流行病杂志,2003,24(5):389-392.
[6]丛建妮,李革,周丹,等.Sp110基因多态性与重庆汉族肺结核遗传易感性关联性研究[J].卫生研究,2010,39(5):540-544.
[7]WHO.Global tuberculosis report 2014[R].WHO:Geneva,2014.
[8]周炳来.结核与免疫[J].临床荟萃,2000,15(10):473-474.
[9]沈卓之,冯子建,马家奇,等.四川省2004年肺结核流行特征及空间聚集性分析[J].现代预防医学,2008,35(8):1412-1413.
[10]周莹,黄迪迪,何丹,等.SP110基因rs11679983A/G多态性与中国南方汉族肺结核易感性研究[J].中华医院感染学杂志,2016,26(7):1477-1479.
[11]周丹,陶杨,蔡家春,等.SP110基因rs1135791、rs722555多态性与结核病的相关性研究[J].现代预防医学,2008,35(3):416-419.
[12]周丹,李革.核体蛋白SP110及其生物学功能[J].医学分子生物学杂志,2006,3(4):271-274.
[13]向颖,林辉,胡代玉,等.SP110和VDR基因多态性与结核病的关联及其与环境因素的交互作用[J].局解手术学杂志,2013,22(4):377-379.
[14]LIANG L,ZHAO YL,YUE J,et al.Association of SP110 gene polymorphisms with susceptibility to tuberculosis in a Chinese population[J].Infect Genet Evol,2011,11(5):934-939.
[15]LI Y,WANG Y,LIU X.The role of airway epithelial cells in response to mycobacteria infection[J].Clin Dev Immunol,2012,2012:791392.
[16]席向宇,张瑞梅,刘慧梅,等.SP110基因多态性与肺结核易感性的关系[J].江苏医药,2017,43(7):480-482.