静脉注射用免疫丙种球蛋白不同给药剂量治疗新生儿ABO溶血病的临床效果
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摘要
目的分析静脉注射用免疫丙种球蛋白(IVIG)不同给药剂量治疗新生儿ABO溶血病的临床效果。方法收集2014年1月至2017年12月我院收治的90例新生儿ABO溶血病患儿的临床资料,根据所接受治疗剂量的不同将患儿分为低剂量组(40例,0.5 g/kg IVIG)与高剂量组(50例,1.0 g/kg IVIG)。比较两组治疗效果。结果治疗后,两组患儿总胆红素水平均显著下降,且高剂量组低于低剂量组(P<0.05)。高剂量组血清总胆红素水平恢复正常时间短于低剂量组(P<0.05)。高剂量组住院、黄疸消退及蓝光照射时间显著短于低剂量组(P<0.05)。结论 IVIG应用于新生儿ABO溶血病治疗中确有较好效果,采用单次高剂量给药可获得更可观的疗效,值得临床推广应用。
Objective To analyze the clinical effect of different administration doses of intravenous immunoglobulin(IVIG) in the treatment of neonatal ABO hemolytic disease. Methods The clinical data of 90 neonatal with ABO hemolytic disease treated in our hospital from January 2014 to December 2017 were collected and the neonatal were divided into low dose group(40 cases, 0.5 g/kg IVIG) and high dose group(50 cases, 1.0 g/kg IVIG) by different treatment doses. The treatment effects were compared between the two groups. Results After treatment, the levels of total bilirubin in the two groups significantly decreased, and that in the high-dose group was lower than the low-dose group(P<0.05). The recovery time of serum total bilirubin level in the high dose group was shorter than that in the low dose group(P<0.05). The time of hospitalization, jaundice subsidence and blue light irradiation in the high dose group were significantly shorter than those in the low dose group(P<0.05). Conclusion IVIG has a good effect in the treatment of neonatal ABO hemolytic disease.Single high dose of IVIG can achieve a more significant effect, which is worthy of clinical application.
Objective To analyze the clinical effect of different administration doses of intravenous immunoglobulin(IVIG) in the treatment of neonatal ABO hemolytic disease. Methods The clinical data of 90 neonatal with ABO hemolytic disease treated in our hospital from January 2014 to December 2017 were collected and the neonatal were divided into low dose group(40 cases, 0.5 g/kg IVIG) and high dose group(50 cases, 1.0 g/kg IVIG) by different treatment doses. The treatment effects were compared between the two groups. Results After treatment, the levels of total bilirubin in the two groups significantly decreased, and that in the high-dose group was lower than the low-dose group(P<0.05). The recovery time of serum total bilirubin level in the high dose group was shorter than that in the low dose group(P<0.05). The time of hospitalization, jaundice subsidence and blue light irradiation in the high dose group were significantly shorter than those in the low dose group(P<0.05). Conclusion IVIG has a good effect in the treatment of neonatal ABO hemolytic disease.Single high dose of IVIG can achieve a more significant effect, which is worthy of clinical application.
引文
[1]张颖辉,冯国仙,孙小莉.静脉滴注丙种球蛋白治疗新生儿肺炎的效果及对免疫功能的影响[J].中国医药科学,2017,7(5):52-55.
[2]彭冬梅.新生儿ABO溶血病早期静脉使用丙种球蛋白联合间断光疗治疗的护理[J].中国医药科学,2018,8(8):146-148.
[3]冯乃超,钟丽花,胡玲.单剂量静脉注射用人血丙种球蛋白治疗新生儿ABO溶血病疗效观察[J].陕西医学杂志,2017,46(11):1592-1593.
[4]卢素琴,汪祝萍,洪燕.人免疫丙种球蛋白辅助治疗小儿重症肺炎的临床疗效及安全性[J].中国地方病防治杂志,2017,32(2):207-208.
[5]刘云凤,邹朝春,杨华琴,等.静脉输注的免疫丙种球蛋白(IVIG)不同给药方式治疗新生儿ABO溶血病的临床疗效比较[J].中国实验血液学杂志,2016,24(6):1842-1845.
[6]郑肖瑾,蔡江云,张耀.人免疫球蛋白对新生儿感染性肺炎免疫指标的影响及疗效[J].检验医学与临床,2017,14(22):3404-3406.
[7]窦蕾.母体注射乙型肝炎免疫球蛋白对乙型肝炎病毒宫内感染的影响及新生儿血清乙型肝炎病毒标志物的动态变化分析[J].中国妇幼保健,2017,32(16):3823-3825.
[8]潘军平,王水云,温晓红.茵栀黄颗粒联合人免疫球蛋白治疗新生儿ABO溶血性黄疸的疗效观察[J].现代药物与临床,2017,32(5):871-874.
[9]刘云凤,邹朝春,杨华琴,等.静脉输注的免疫丙种球蛋白(IVIG)不同给药方式治疗新生儿ABO溶血病的临床疗效比较[J].中国实验血液学杂志,2016,24(6):1842-1845.
[2]彭冬梅.新生儿ABO溶血病早期静脉使用丙种球蛋白联合间断光疗治疗的护理[J].中国医药科学,2018,8(8):146-148.
[3]冯乃超,钟丽花,胡玲.单剂量静脉注射用人血丙种球蛋白治疗新生儿ABO溶血病疗效观察[J].陕西医学杂志,2017,46(11):1592-1593.
[4]卢素琴,汪祝萍,洪燕.人免疫丙种球蛋白辅助治疗小儿重症肺炎的临床疗效及安全性[J].中国地方病防治杂志,2017,32(2):207-208.
[5]刘云凤,邹朝春,杨华琴,等.静脉输注的免疫丙种球蛋白(IVIG)不同给药方式治疗新生儿ABO溶血病的临床疗效比较[J].中国实验血液学杂志,2016,24(6):1842-1845.
[6]郑肖瑾,蔡江云,张耀.人免疫球蛋白对新生儿感染性肺炎免疫指标的影响及疗效[J].检验医学与临床,2017,14(22):3404-3406.
[7]窦蕾.母体注射乙型肝炎免疫球蛋白对乙型肝炎病毒宫内感染的影响及新生儿血清乙型肝炎病毒标志物的动态变化分析[J].中国妇幼保健,2017,32(16):3823-3825.
[8]潘军平,王水云,温晓红.茵栀黄颗粒联合人免疫球蛋白治疗新生儿ABO溶血性黄疸的疗效观察[J].现代药物与临床,2017,32(5):871-874.
[9]刘云凤,邹朝春,杨华琴,等.静脉输注的免疫丙种球蛋白(IVIG)不同给药方式治疗新生儿ABO溶血病的临床疗效比较[J].中国实验血液学杂志,2016,24(6):1842-1845.