从“心胸内关谋”浅论经穴脏腑相关学说
|
摘要
内关穴与心脏密切相关有着大量的理论与实验依据,但当前大部分研究,如经穴诊断方面研究仍停留在初步认识阶段,缺乏系统性的机制探索。经穴脏腑相关的实质可能是在一定物质结构基础上,经穴状态、脏腑组织功能状态自身调节,动态塑造后的彼此影响。以内关穴与心脏交互作用为切入点,运用高通量的表观遗传技术,研究经穴脏腑相关学说对深入挖掘和阐释经穴脏腑理论的科学内涵具有重要意义。
引文
[1]Rong P,Bing Z,Li Y,et al.Mechanism of acupuncture regulating visceral sensation and mobility[J].Front Med,2011,5(2):151.
[2]刘立公,顾杰.古代文献中肺经及其腧穴主治的统计报告[J].上海针灸杂志,2002,21(6):38.
[3]嵇波,李晓泓,张露芬,等.基于临床的经穴-脏腑相关研究进展评述[J].中国针灸,2012,32(4):382.
[4]杨广印,许金森,吴祖星.消化系统疾病患者在督脉背段的压痛反应规律[J].中国针灸,2012,32(2):135.
[5]Ots T,Mayor D,Beissner F,et al.Forgotten features of head zones and their relation to diagnostically relevant acupuncture points[J].Evid Based Complement Alternat Med,2011,2011(1):240653.
[6]王诗惠,龙杞,刘清国.穴位诊断法的研究概况与展望[J].上海针灸杂志,2014,33(1):91.
[7]刘俊岭,王俊英,陈淑萍,等.经穴/经脉-脏腑相关及其机制研究的进展[J].针刺研究,2010,35(1):71.
[8]嵇波,李晓泓,张露芬,等.基于正常人经穴脏腑相关的临床研究情况分析[J].针灸临床杂志,2012,28(4):71.
[9]朱兵.系统针灸学-复兴体表医学[M].北京:人民卫生出版社,2015:382.
[10]何伟,吴美玲,景向红,等.穴位的本态:穴位组织细胞化学的动态变化[J].中国针灸,2015,35(11):1181.
[11]李思颉,张颜波,任长虹,等.新发现的脊神经节的核团特性在经穴脏腑相关中的作用[J].中华中医药杂志,2015,30(10):3594.
[12]Zhu WL,Li Y,Wei HF,et al.Effect of electro-acupuncture at different acupoints on neuropeptide and somatostatin in rat brain with irritable bowel syndrome[J].Chin J Integr Med,2012,18(4):288.
[13]刘延莉,王明山,李秋杰,等.经皮穴位电刺激治疗剖宫产产妇恶心呕吐及对血浆5-HT浓度的影响[J].中国针灸,2015,35(10):1039.
[14]周逸平,汪克明,胡玲,等.心经经脉与心脏相关的差异表达基因的研究[J].针刺研究,2007,32(1):3.
[15]田浩梅,严洁,易受乡,等.电针胃经经穴促进大鼠胃黏膜修复过程中相关蛋白磷酸化的研究[J].针刺研究,2009,34(3):147.
[16]吴巧凤,杨阳,赵纪岚,等.基于1HNMR代谢组学技术研究针刺经穴与非经穴治疗溃疡性结肠炎的脑代谢物质基础[J].北京中医药大学学报,2014,37(8):572.
[17]Wang G,Tian Y,Jia S,et al.Acupuncture regulates the heart rate variability[J].J Acupunct Meridian Stud,2014,8(2):94.
[18]Sun J,Li X,Yang C,et al.Transcutaneous electrical acupuncture stimulation as a countermeasure against cardiovascular deconditioning during 4 days of head-down bed rest in humans[J].Acupunct Med,2015,33(5):381.
[19]王宁,陈慧,卢圣锋,等.针刺内关对慢性稳定型心绞痛患者中性粒细胞与淋巴细胞比率的影响[J].中国针灸,2015,35(5):417.
[20]马福国,张彦平,陈怀龙,等.电针内关穴对心脏瓣膜置换术患者氧化应激的影响[J].中国针灸,2015,35(7):707.
[21]李启云.心肌梗死与心包经双侧经络电阻抗失衡的相关研究[J].中国全科医学,2004,7(11):791.
[22]Wang S,Lu R,Jia L,et al.Effect of acupuncture at Neiguan(PC 6)on cardiac function using echocardiography in myocardial ischemia rats induced by isoproterenol[J].J Tradit Chin Med,2015,35(6):653.
[23]Wang W,Li J,Meng X,et al.Effect of electronic stimulation at Neiguan(PC 6)acupoint on gene expression of adenosine triphosphate-sensitive potassium channel and protein kinases in rats with myocardial ischemia[J].J Tradit Chin Med,2015,35(5):577.
[24]Wang S,Zhang L,Dong B,et al.Protein and RNA expression of acid-sensing ion channels 2 and 3 in myocardial ischemia rats induced by isoproterenol[J].J Tradit Chin Med,2015,35(2):222.
[25]Wang Y,Wang W,Li D,et al.The beneficial effect of electro-acupuncture given at PC6(Neiguan-point)by the increase in cardiac transient outward K+current channel which depends on the gene and protein expressions in artificially induced myocardial ischemia rats[J].Acupunct Electrother Res,2014,39(3-4):259.
[26]王超,田岳凤,周丹,等.电针"内关"穴对心肌缺血再灌注大鼠心肌组织一氧化氮、一氧化氮合酶和细胞内钙的影响[J].针刺研究,2010,35(2):113.
[27]方继良,周晟芳,刘欢,等.内关穴埋针疗法对慢性心肌缺血模型猪心电图改变的影响[J].中国中西医结合杂志,2016,36(12):1470.
[28]Dong B,Li C,Zhang X,et al.Electroacupuncture of neiguan(PC 6)inhibits enhanced voltage-gated sodium currents in ischemic ventricular myocytes[J].J Tradit Chin Med,2014,34(6):710.
[29]Gao J,Zhao Y,Wang Y,et al.Anti-arrhythmic effect of acupuncture pretreatment in the rats subjected to simulative global ischemia and reperfusion—involvement of intracellular Ca2+and connexin 43[J].BMC Complement Altern Med,2015,15(1):1.
[30]丁亚娟,卢圣锋,陈霞,等.不同时间电针预处理对大鼠心肌缺血损伤及HIF-1α表达的影响[J].南京中医药大学学报,2017,33(1):40.
[31]Huang Y,Lu SF,Hu CJ,et al.Electro-acupuncture at Neiguan pretreatment alters genome-wide gene expressions and protects rat myocardium against ischemia-reperfusion[J].Molecules,2014,19(10):16158.
[32]Fu S P,He S Y,Xu B,et al.Acupuncture promotes angiogenesis after myocardial ischemia through H3K9 acetylation regulation at VEGF gene[J].Plos One,2014,9(4):e94604.
[33]Multifunctional Merkel cells:their roles in electromagnetic reception,finger-print formation,Reiki,epigenetic inheritance and hair form[J].Med Hypotheses,2010,75(2):162.
[34]Pan Z W,Lu Y J,Yang B F.Advances in exploring the role of microRNAs in the pathogenesis,diagnosis and therapy of cardiac diseases in China[J].Br J Pharmacol,2015,172(23):5435.
[35]Schttker B,Yan Z,Heiss J A,et al.Discovery of a novel epigenetic cancer marker related to the oxidative status of human blood[J].Gene Chromosome Canc,2015,54(9):583.
[36]Wang J Y,Li H,Ma C M,et al.Acupuncture may exert Its therapeutic effect through microRNA-339/Sirt2/NFκB/FOXO1 axis[J].Biomed Res Int,2015,2015:249013.
[2]刘立公,顾杰.古代文献中肺经及其腧穴主治的统计报告[J].上海针灸杂志,2002,21(6):38.
[3]嵇波,李晓泓,张露芬,等.基于临床的经穴-脏腑相关研究进展评述[J].中国针灸,2012,32(4):382.
[4]杨广印,许金森,吴祖星.消化系统疾病患者在督脉背段的压痛反应规律[J].中国针灸,2012,32(2):135.
[5]Ots T,Mayor D,Beissner F,et al.Forgotten features of head zones and their relation to diagnostically relevant acupuncture points[J].Evid Based Complement Alternat Med,2011,2011(1):240653.
[6]王诗惠,龙杞,刘清国.穴位诊断法的研究概况与展望[J].上海针灸杂志,2014,33(1):91.
[7]刘俊岭,王俊英,陈淑萍,等.经穴/经脉-脏腑相关及其机制研究的进展[J].针刺研究,2010,35(1):71.
[8]嵇波,李晓泓,张露芬,等.基于正常人经穴脏腑相关的临床研究情况分析[J].针灸临床杂志,2012,28(4):71.
[9]朱兵.系统针灸学-复兴体表医学[M].北京:人民卫生出版社,2015:382.
[10]何伟,吴美玲,景向红,等.穴位的本态:穴位组织细胞化学的动态变化[J].中国针灸,2015,35(11):1181.
[11]李思颉,张颜波,任长虹,等.新发现的脊神经节的核团特性在经穴脏腑相关中的作用[J].中华中医药杂志,2015,30(10):3594.
[12]Zhu WL,Li Y,Wei HF,et al.Effect of electro-acupuncture at different acupoints on neuropeptide and somatostatin in rat brain with irritable bowel syndrome[J].Chin J Integr Med,2012,18(4):288.
[13]刘延莉,王明山,李秋杰,等.经皮穴位电刺激治疗剖宫产产妇恶心呕吐及对血浆5-HT浓度的影响[J].中国针灸,2015,35(10):1039.
[14]周逸平,汪克明,胡玲,等.心经经脉与心脏相关的差异表达基因的研究[J].针刺研究,2007,32(1):3.
[15]田浩梅,严洁,易受乡,等.电针胃经经穴促进大鼠胃黏膜修复过程中相关蛋白磷酸化的研究[J].针刺研究,2009,34(3):147.
[16]吴巧凤,杨阳,赵纪岚,等.基于1HNMR代谢组学技术研究针刺经穴与非经穴治疗溃疡性结肠炎的脑代谢物质基础[J].北京中医药大学学报,2014,37(8):572.
[17]Wang G,Tian Y,Jia S,et al.Acupuncture regulates the heart rate variability[J].J Acupunct Meridian Stud,2014,8(2):94.
[18]Sun J,Li X,Yang C,et al.Transcutaneous electrical acupuncture stimulation as a countermeasure against cardiovascular deconditioning during 4 days of head-down bed rest in humans[J].Acupunct Med,2015,33(5):381.
[19]王宁,陈慧,卢圣锋,等.针刺内关对慢性稳定型心绞痛患者中性粒细胞与淋巴细胞比率的影响[J].中国针灸,2015,35(5):417.
[20]马福国,张彦平,陈怀龙,等.电针内关穴对心脏瓣膜置换术患者氧化应激的影响[J].中国针灸,2015,35(7):707.
[21]李启云.心肌梗死与心包经双侧经络电阻抗失衡的相关研究[J].中国全科医学,2004,7(11):791.
[22]Wang S,Lu R,Jia L,et al.Effect of acupuncture at Neiguan(PC 6)on cardiac function using echocardiography in myocardial ischemia rats induced by isoproterenol[J].J Tradit Chin Med,2015,35(6):653.
[23]Wang W,Li J,Meng X,et al.Effect of electronic stimulation at Neiguan(PC 6)acupoint on gene expression of adenosine triphosphate-sensitive potassium channel and protein kinases in rats with myocardial ischemia[J].J Tradit Chin Med,2015,35(5):577.
[24]Wang S,Zhang L,Dong B,et al.Protein and RNA expression of acid-sensing ion channels 2 and 3 in myocardial ischemia rats induced by isoproterenol[J].J Tradit Chin Med,2015,35(2):222.
[25]Wang Y,Wang W,Li D,et al.The beneficial effect of electro-acupuncture given at PC6(Neiguan-point)by the increase in cardiac transient outward K+current channel which depends on the gene and protein expressions in artificially induced myocardial ischemia rats[J].Acupunct Electrother Res,2014,39(3-4):259.
[26]王超,田岳凤,周丹,等.电针"内关"穴对心肌缺血再灌注大鼠心肌组织一氧化氮、一氧化氮合酶和细胞内钙的影响[J].针刺研究,2010,35(2):113.
[27]方继良,周晟芳,刘欢,等.内关穴埋针疗法对慢性心肌缺血模型猪心电图改变的影响[J].中国中西医结合杂志,2016,36(12):1470.
[28]Dong B,Li C,Zhang X,et al.Electroacupuncture of neiguan(PC 6)inhibits enhanced voltage-gated sodium currents in ischemic ventricular myocytes[J].J Tradit Chin Med,2014,34(6):710.
[29]Gao J,Zhao Y,Wang Y,et al.Anti-arrhythmic effect of acupuncture pretreatment in the rats subjected to simulative global ischemia and reperfusion—involvement of intracellular Ca2+and connexin 43[J].BMC Complement Altern Med,2015,15(1):1.
[30]丁亚娟,卢圣锋,陈霞,等.不同时间电针预处理对大鼠心肌缺血损伤及HIF-1α表达的影响[J].南京中医药大学学报,2017,33(1):40.
[31]Huang Y,Lu SF,Hu CJ,et al.Electro-acupuncture at Neiguan pretreatment alters genome-wide gene expressions and protects rat myocardium against ischemia-reperfusion[J].Molecules,2014,19(10):16158.
[32]Fu S P,He S Y,Xu B,et al.Acupuncture promotes angiogenesis after myocardial ischemia through H3K9 acetylation regulation at VEGF gene[J].Plos One,2014,9(4):e94604.
[33]Multifunctional Merkel cells:their roles in electromagnetic reception,finger-print formation,Reiki,epigenetic inheritance and hair form[J].Med Hypotheses,2010,75(2):162.
[34]Pan Z W,Lu Y J,Yang B F.Advances in exploring the role of microRNAs in the pathogenesis,diagnosis and therapy of cardiac diseases in China[J].Br J Pharmacol,2015,172(23):5435.
[35]Schttker B,Yan Z,Heiss J A,et al.Discovery of a novel epigenetic cancer marker related to the oxidative status of human blood[J].Gene Chromosome Canc,2015,54(9):583.
[36]Wang J Y,Li H,Ma C M,et al.Acupuncture may exert Its therapeutic effect through microRNA-339/Sirt2/NFκB/FOXO1 axis[J].Biomed Res Int,2015,2015:249013.