三氯生的致突变性和致癌作用研究进展
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摘要
目的澄清三氯生的致突变性和致癌作用。方法以"三氯生"、"致突变性"和"致癌作用"作为CNKI数据库的检索关键词;以"triclosan"、"mutagenicity"和"carcinogenicity"作为关键词在Pubmed数据库中检索相关文献。结果鼠伤寒沙门菌细菌回复突变试验和哺乳动物细胞基因突变试验显示,三氯生不会引起原核生物和真核生物基因突变;彗星和微核试验显示,三氯生不具有致哺乳动物DNA损伤和染色体畸变作用;现有资料不足以支持三氯生暴露会直接引起人体罹患肿瘤。结论三氯生对细菌、哺乳动物和人都不具有致突变性和致癌性,为三氯生的科学管理与合理使用提供了依据。
Objective The study aimed to show the mutagenic and carcinogenicity effect of triclosan. Methods The progress in the studies on the mutagenic effects in prokaryotes and eukaryotes and the carcinogenicity of triclosan are reviewed in the present paper via CNKI and Pubmed database. Results Triclosan was considered to be not mutagenic or carcinogenic to humans. Later, the FDA banned the addition of triclosan to soap in 2016 due to the doubts about the antibacterial effect of triclosan in hand washing products and concerns about the potential adverse effects on microorganisms in water. Since then,the genetic toxicity of triclosan has been refocused on, but the results are inconsistent. In addition, triclosan is still used as an antibacterial component in China. So it is necessary to review the genetic toxicity of triclosan. Conclusion Current data show that triclosan is not mutagenic or carcinogenic to bacteria, mammals and humans, providing a basis for the reasonable use and management of triclosan.
Objective The study aimed to show the mutagenic and carcinogenicity effect of triclosan. Methods The progress in the studies on the mutagenic effects in prokaryotes and eukaryotes and the carcinogenicity of triclosan are reviewed in the present paper via CNKI and Pubmed database. Results Triclosan was considered to be not mutagenic or carcinogenic to humans. Later, the FDA banned the addition of triclosan to soap in 2016 due to the doubts about the antibacterial effect of triclosan in hand washing products and concerns about the potential adverse effects on microorganisms in water. Since then,the genetic toxicity of triclosan has been refocused on, but the results are inconsistent. In addition, triclosan is still used as an antibacterial component in China. So it is necessary to review the genetic toxicity of triclosan. Conclusion Current data show that triclosan is not mutagenic or carcinogenic to bacteria, mammals and humans, providing a basis for the reasonable use and management of triclosan.
引文
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[3]张凤兰,苏哲,吴景,等.三氯生安全性评价及化妆品法规管理现状[J].环境与健康杂志,2017,34(10):918-921.
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[8] Jirasripongpun K, Wongarethornkul T, Mulliganavin S. Risk assess-ment of triclosan using animal cell lines[J]. Kasetsart Journal(NaturalScience), 2008, 42:353-359.
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[12] Dann AB, Hontela A. Triclosan:environmental exposure, toxicity andmechanisms of action[J]. Journal of Applied Toxicology, 2011, 31(4):285-311.
[13]陈建军,豆晓飞,刘海津,等.三氯生致泥鳅生理及遗传毒性作用[J].中国公共卫生,2013,29(7):1014-1016.
[14] Binelli A, Cogni D, Parolini M, et al. In vivo experiments for the e-valuation of genotoxic and cytotoxic effects of Triclosan in Zebramussel hemocytes[J]. Aquatic toxicology(Amsterdam, Netherlands),2009, 91(3):238-244.
[15] Capkin E, Ozcelep T, Kayis S, et al. Antimicrobial agents, triclosan,chloroxylenol, methylisothiazolinone and borax, used in cleaning hadgenotoxic and histopathologic effects on rainbow trout[J]. Chemo-sphere, 2017, 182:720-729.
[16] Binelli A, Cogni D, Parolini M, et al. Cytotoxic and genotoxic effectsof in vitro exposure to Triclosan and Trimethoprim on zebra mussel(Dreissena polymorpha)hemocytes[J]. Comparative Biochemistry andPhysiology C-Toxicology&Pharmacology, 2009, 150(1):50-56.
[17] Wang F, Xu RJ, Zheng FF, et al. Effects of triclosan on acute toxicity,genetic toxicity and oxidative stress in goldfish(Carassius auratus)[J].Experimental Animals, 2018, 67(2):219-227.
[18]李林朋,马慧敏,胡俊杰,等.三氯生和三氯卡班对人体肝细胞DNA损伤的研究[J].生态环境学报,2010,19(12):2897-2901.
[19] Yueh MF, Taniguchi K, Chen SJ, et al. The commonly used antimi-crobial additive triclosan is a liver tumor promoter[J]. Proceedings ofthe National Academy of Sciences of the United States of America,2014, 111(48):17200-17205.
[20] Lake BG, Price RJ, Osimitz TG. Mode of action analysis for pesticide-induced rodent liver tumours involving activation of the constitutiveandrostane receptor:relevance to human cancer risk[J]. Pest Man-agement Science, 2015, 71(6, SI):829-834.
[21] Dinwiddie MT, Terry PD, Chen JA. Recent evidence regarding tri-closan and cancer risk[J]. International Journal of EnvironmentalResearch and Public Health, 2014, 11(2):2209-2217.
[22]国家食品药品监督管理总局.世界卫生组织国际癌症研究机构致癌物清单[EB/OL].[2019-01-12].http://samr.cfda.gov.cn/WS01/CL1991/215896.html.
[23] Winitthana T, Lawanprasert S, Chanvorachote P. Triclosan potenti-ates epithelial-to-mesenchymal transition in anoikis-resistanthuman lung cancer cells[J]. PLOS One, 2014, 9(10):e110851.
[24] Lee HR, Hwang KA, Nam KH, et al. Progression of breast cancercells was enhanced by Endocrine-Disrupting chemicals, triclosanand octylphenol, via an estrogen Receptor-Dependent signalingpathway in cellular and mouse xenog raft models[J]. Chemical Re-search in Toxicology, 2014, 27(5):834-842.
[25] Kim JY, Yi BR, Go RE, et al. Methoxychlor and triclosan stimulatesovarian cancer growth by regulating cell cycle-and apoptosis-re-lated genes via an estrogen receptor-dependent pathway[J]. Envi-ronmental Toxicology and Pharmacology, 2014, 37(3):1264-1274.
[26] Kim SH, Hwang KA, Shim SM, et al. Growth and migration of LNCa Pprostate cancer cells are promoted by triclosan and benzophenone-1 via an androgen receptor signaling pathway[J]. Environmental Tox-icology and Pharmacology, 2015, 39(2):568-576.
[27] Azzouz A, Rascon AJ, Ballesteros E. Simultaneous determination ofparabens, alkylphenols, phenylphenols, bisphenol A and triclosan inhuman urine, blood and breast milk by continuous solid-phase ex-traction and gas chromatography-mass spectrometry[J]. Journal ofPharmaceutical and Biomedical Analysis, 2016, 119:16-26.
[2] Mcnamara PJ, Levy SB. Triclosan:an instructive tale[J]. Antimicro-bial Agents and Chemotherapy, 2016, 60(12):7015-7016.
[3]张凤兰,苏哲,吴景,等.三氯生安全性评价及化妆品法规管理现状[J].环境与健康杂志,2017,34(10):918-921.
[4] Wang ZM, Li XL, Klaunig JE. Investigation of the mechanism of tri-closan induced mouse liver tumors[J]. Regulatory Toxicology andPharmacology, 2017, 86:137-147.
[5] Rodricks JV, Swenberg JA, Borzelleca JF, et al. Triclosan:a criticalreview of the experimental data and development of margins of safetyfor consumer products[J]. Critical Reviews in Toxicology, 2010, 40(5):422-484.
[6]郑欣,刘婷婷,王一喆,等.三氯生毒性效应及水质基准研究进展[J].生态环境学报,2016,25(3):539-546.
[7]曹易懿,奚晶,唐伟锋,等.三氯生的体外遗传毒性评价[J].癌变·畸变·突变,2018,30(1):71-75.
[8] Jirasripongpun K, Wongarethornkul T, Mulliganavin S. Risk assess-ment of triclosan using animal cell lines[J]. Kasetsart Journal(NaturalScience), 2008, 42:353-359.
[9] Chaung WR, Mi LJ, Boorstein RJ. The p53 status of Chinese hamsterV79 cells frequently used for studies on DNA damage and DNA re-pair[J]. Nucleic Acids Research, 1997, 25(5):992-994.
[10] Tweats DJ, Scott D, Westmoreland C, et al. Determination of genetictoxicity and potential carcinogenicity in vitro-challenges post theSeventh Amendment to the European Cosmetics Directive[J]. Muta-genesis, 2007, 22(1):5-13.
[11] Ciniglia C, Cascone C, Giudice RL, et al. Application of methods forassessing the geno-and cytotoxicity of Triclosan to C. ehrenbergii[J]. Journal of Hazardous Materials, 2005, 122(3):227-232.
[12] Dann AB, Hontela A. Triclosan:environmental exposure, toxicity andmechanisms of action[J]. Journal of Applied Toxicology, 2011, 31(4):285-311.
[13]陈建军,豆晓飞,刘海津,等.三氯生致泥鳅生理及遗传毒性作用[J].中国公共卫生,2013,29(7):1014-1016.
[14] Binelli A, Cogni D, Parolini M, et al. In vivo experiments for the e-valuation of genotoxic and cytotoxic effects of Triclosan in Zebramussel hemocytes[J]. Aquatic toxicology(Amsterdam, Netherlands),2009, 91(3):238-244.
[15] Capkin E, Ozcelep T, Kayis S, et al. Antimicrobial agents, triclosan,chloroxylenol, methylisothiazolinone and borax, used in cleaning hadgenotoxic and histopathologic effects on rainbow trout[J]. Chemo-sphere, 2017, 182:720-729.
[16] Binelli A, Cogni D, Parolini M, et al. Cytotoxic and genotoxic effectsof in vitro exposure to Triclosan and Trimethoprim on zebra mussel(Dreissena polymorpha)hemocytes[J]. Comparative Biochemistry andPhysiology C-Toxicology&Pharmacology, 2009, 150(1):50-56.
[17] Wang F, Xu RJ, Zheng FF, et al. Effects of triclosan on acute toxicity,genetic toxicity and oxidative stress in goldfish(Carassius auratus)[J].Experimental Animals, 2018, 67(2):219-227.
[18]李林朋,马慧敏,胡俊杰,等.三氯生和三氯卡班对人体肝细胞DNA损伤的研究[J].生态环境学报,2010,19(12):2897-2901.
[19] Yueh MF, Taniguchi K, Chen SJ, et al. The commonly used antimi-crobial additive triclosan is a liver tumor promoter[J]. Proceedings ofthe National Academy of Sciences of the United States of America,2014, 111(48):17200-17205.
[20] Lake BG, Price RJ, Osimitz TG. Mode of action analysis for pesticide-induced rodent liver tumours involving activation of the constitutiveandrostane receptor:relevance to human cancer risk[J]. Pest Man-agement Science, 2015, 71(6, SI):829-834.
[21] Dinwiddie MT, Terry PD, Chen JA. Recent evidence regarding tri-closan and cancer risk[J]. International Journal of EnvironmentalResearch and Public Health, 2014, 11(2):2209-2217.
[22]国家食品药品监督管理总局.世界卫生组织国际癌症研究机构致癌物清单[EB/OL].[2019-01-12].http://samr.cfda.gov.cn/WS01/CL1991/215896.html.
[23] Winitthana T, Lawanprasert S, Chanvorachote P. Triclosan potenti-ates epithelial-to-mesenchymal transition in anoikis-resistanthuman lung cancer cells[J]. PLOS One, 2014, 9(10):e110851.
[24] Lee HR, Hwang KA, Nam KH, et al. Progression of breast cancercells was enhanced by Endocrine-Disrupting chemicals, triclosanand octylphenol, via an estrogen Receptor-Dependent signalingpathway in cellular and mouse xenog raft models[J]. Chemical Re-search in Toxicology, 2014, 27(5):834-842.
[25] Kim JY, Yi BR, Go RE, et al. Methoxychlor and triclosan stimulatesovarian cancer growth by regulating cell cycle-and apoptosis-re-lated genes via an estrogen receptor-dependent pathway[J]. Envi-ronmental Toxicology and Pharmacology, 2014, 37(3):1264-1274.
[26] Kim SH, Hwang KA, Shim SM, et al. Growth and migration of LNCa Pprostate cancer cells are promoted by triclosan and benzophenone-1 via an androgen receptor signaling pathway[J]. Environmental Tox-icology and Pharmacology, 2015, 39(2):568-576.
[27] Azzouz A, Rascon AJ, Ballesteros E. Simultaneous determination ofparabens, alkylphenols, phenylphenols, bisphenol A and triclosan inhuman urine, blood and breast milk by continuous solid-phase ex-traction and gas chromatography-mass spectrometry[J]. Journal ofPharmaceutical and Biomedical Analysis, 2016, 119:16-26.