载脂蛋白E基因与脑皮层厚度变化的研究
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摘要
目的:研究载脂蛋白E基因携带及其剂量对脑皮层厚度变化的影响。方法:研究对象包含44个不携带ApoEε4等位基因,32个ApoEε4杂合子和27个ApoEε4纯合子中年受试者。Freesurfer软件将每个对象的左右脑分别分割为35个感兴趣区域并获取皮层厚度。结果:在ApoEε4等位基因携带者和非携带者间,多个脑区存在显著的皮层厚度差异。同时,其中的部分脑区与认知能力和ApoEε4等位基因遗传剂量间存在显著相关。结论:MRI是一个对早期AD病理脑结构重组敏感的检测工具。
Objective: To examine the relationships among apolipoprotein E(APOE) ε4 carriers, their dose and cortical thickness.Methods: Participants included 44 middle-aged non-carriers, 32 APOE ε4 heterozygotes and 27 APOE ε4. Volumetric T1 MRI scans were processed using Freesurfer software to measure cortical thickness in 35 regions of interest from each hemisphere.Results: There were significant differences in cortical thickness between the APOE ε4 carriers and non carriers in some brain regions. Moreover, part of those regions were associated with memory performance and APOE ε4 dose. Conclusion: MRI may be a sensitive tool for detecting brain structural reorganization in early AD pathology.
Objective: To examine the relationships among apolipoprotein E(APOE) ε4 carriers, their dose and cortical thickness.Methods: Participants included 44 middle-aged non-carriers, 32 APOE ε4 heterozygotes and 27 APOE ε4. Volumetric T1 MRI scans were processed using Freesurfer software to measure cortical thickness in 35 regions of interest from each hemisphere.Results: There were significant differences in cortical thickness between the APOE ε4 carriers and non carriers in some brain regions. Moreover, part of those regions were associated with memory performance and APOE ε4 dose. Conclusion: MRI may be a sensitive tool for detecting brain structural reorganization in early AD pathology.
引文
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[10]程蕊,李玺,王娟,等.载脂蛋白E基因多态性与阿尔茨海默病相关性的Meta分析[J].实用老年医学,2018,32(03):263-267.
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[14]Cacciaglia R,Molinuevo J L,Falcón Cet al.Effects of APOE-ε4 allele load on brain morphology in a cohort of middle-aged healthy individuals with enriched genetic risk for Alzheimer's disease.Alzheimers Dement.,201814(7):902-912.
[15]Dale A M,Fischl B,Sereno M I.Cortical Surface-Based Analysis I:Segmentation and Surface Reconstruction[J].Neuro Image,1999,9(2):179-194.
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[17]Fischl B,Dale A M.Measuring the thickness of the human cerebral cortex from magnetic resonance images[J].Proc Natl Acad Sci,2000,97(20):11050-11055.
[2]Lin L,Fu Z,Xu X,et al.Mouse brain magnetic resonance microscopy:Applications in Alzheimer disease[J].Microsc Res Tech,201578(5):416-424.
[3]李传明,王健,周代全.功能磁共振技术在老年性痴呆中的应用研究进展[J].医疗卫生装备2010,(4):154-156.
[4]靳聪,林岚,付振荣,等.MRI在阿尔茨海默氏病中的应用研究进展[J].智慧健康,20151(1):52-56.
[5]张柏雯,林岚,吴水才.深度学习在轻度认知障碍转化与分类中的应用分析[J].医疗卫生装备,2017(9):105-111.
[6]张鹏,王沥,杨泽,等.老年痴呆关联基因的研究进展[J].遗传,2003,25(4):445-449.
[7]王丁一,杨欢,周亮,等.Apo E与阿尔茨海默病[J].神经疾病与精神卫生,2009,9(2):93-95.
[8]邢丽菲,王敏,檀素娟,等.载脂蛋白E基因多态性与Alzheimer病和血管性痴呆的关系研究[J].中西医结合心血管病电子杂志,20186(22):110-111.
[9]刘淑静,常欣魁,陈柯霖,等.载脂蛋白E基因多态性与脑梗患者年龄和血脂的相关性研究[J].标记免疫分析与临床,2018,25(11):1595-1598.
[10]程蕊,李玺,王娟,等.载脂蛋白E基因多态性与阿尔茨海默病相关性的Meta分析[J].实用老年医学,2018,32(03):263-267.
[11]Small G W.Use of neuroimaging to detect early brain changes in people at genetic risk for Alzheimer's disease[J].Adv Drug Deliv Rev2002,54(12):1561-1566.
[12]Liu C C,Kanekiyo T,Xu H,et al Apolipoprotein E and Alzheimer disease:risk,mechanisms and therapy[J].Nat Rev Neurol,2013,9(2):106-118.
[13]Caselli R J,Dueck A C,Osborne D,et al.Longitudinal modeling of age-related memory decline and the APOE epsilon4 effect[J].N Engl J Med,2009,361(3):255-263.
[14]Cacciaglia R,Molinuevo J L,Falcón Cet al.Effects of APOE-ε4 allele load on brain morphology in a cohort of middle-aged healthy individuals with enriched genetic risk for Alzheimer's disease.Alzheimers Dement.,201814(7):902-912.
[15]Dale A M,Fischl B,Sereno M I.Cortical Surface-Based Analysis I:Segmentation and Surface Reconstruction[J].Neuro Image,1999,9(2):179-194.
[16]Fischl B,Sereno M I,Dale A M.Cortical Surface-Based Analysis II:Inflation,Flattening,and a Surface-Based Coordinate System[J].Neuro Image,1999,9(2):195-207.
[17]Fischl B,Dale A M.Measuring the thickness of the human cerebral cortex from magnetic resonance images[J].Proc Natl Acad Sci,2000,97(20):11050-11055.
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