针刺联合尼莫地平治疗100例血管性痴呆患者的临床疗效分析
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摘要
目的观察针灸联合尼莫地平治疗血管性痴呆患者的临床疗效。方法选自2017年8月至2018年8月在太原市中心医院收治的100例血管性痴呆的患者,按照随机数字表法,分为观察组50例和对照组50例,观察组患者给针刺联合尼莫地平治疗,对照组仅给予尼莫地平治疗,治疗2个月后观察并比较2组患者的简易智能状态量表(MMSE)评分、长谷川量表(HDS)评分和日常生活能力量表(ADL)评分的改善情况。结果治疗前2组患者的MMSE评分、HDS评分、ADL评分组间无差异(P>0.05),治疗后2组患者的MMSE评分、HDS评分、ADL评分均较治疗前增高,差异具有显著性(P<0.05),且治疗后实验组的HDS评分、ADL评分均高于对照组,且差异显著(P<0.05)。结论针灸联合尼莫地平治疗血管性痴呆的临床疗效优于单用尼莫地平的情况,且安全性较好,值得在临床上推广运用。
Objective To evaluate the efficacy and safety of acupuncture combined with nimodipine in patients with vascular dementia. Methods A total of 100 patients with vascular dementia were enrolled in line with the inclusion criteria and divided into observation group and control group by random figure table, with 50 cases in each group. The control group was treated with nimodipine only and the observation group was treated acupuncture combined with nimodipine.After 8 weeks of treatment, the changes of the scores of Simple Intelligence State Scale(MMSE),the Hasegawa Scale(HDS) score and the Daily Living Ability Scale(ADL) score were observed and compared.Results There was no difference in MMSE score, HDS score and ADL score between the two groups before treatment(P>0.05). After treatment, the scores of MMSE, HDS and ADL in both groups were higher than those before treatment,and the difference was significant(P<0.05). Besides, the HDS score and ADL score of the experimental group were higher than those of the control group after treatment(P<0.05). There was no obvious adverse reactionn between the observation group and the control group. Conclusion The clinical efficacy of acupuncture combined with nimodipine in the treatment of vascular dementia is better than that of nimodipine alone and no obvious adverse reactions were found.It is worth popularizing in clinical practice.
Objective To evaluate the efficacy and safety of acupuncture combined with nimodipine in patients with vascular dementia. Methods A total of 100 patients with vascular dementia were enrolled in line with the inclusion criteria and divided into observation group and control group by random figure table, with 50 cases in each group. The control group was treated with nimodipine only and the observation group was treated acupuncture combined with nimodipine.After 8 weeks of treatment, the changes of the scores of Simple Intelligence State Scale(MMSE),the Hasegawa Scale(HDS) score and the Daily Living Ability Scale(ADL) score were observed and compared.Results There was no difference in MMSE score, HDS score and ADL score between the two groups before treatment(P>0.05). After treatment, the scores of MMSE, HDS and ADL in both groups were higher than those before treatment,and the difference was significant(P<0.05). Besides, the HDS score and ADL score of the experimental group were higher than those of the control group after treatment(P<0.05). There was no obvious adverse reactionn between the observation group and the control group. Conclusion The clinical efficacy of acupuncture combined with nimodipine in the treatment of vascular dementia is better than that of nimodipine alone and no obvious adverse reactions were found.It is worth popularizing in clinical practice.
引文
[1]张立,邢艳丽,熊伟南.血管性痴呆治疗的研究进展[J].医学综述,2015,21(8):1414-1417.
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[3]王民.奥拉西坦联合尼莫地平治疗血管性痴呆疗效分析[J].中国实用神经疾病杂志,2014,17(14):93-95.
[4]马青,唐民科,孙文燕,等.血管性痴呆中医发病机制现代研究述要[J].中华中医药杂志,2018,33(1):212-215.
[5]曹宇,裴卉,刘美霞,等.血管性痴呆的遗传学机制研究进展[J].中国临床神经科学,2017,25(5):586-594.
[6]武胜涛,张羽,李富慧,等.缺血性脑卒中后血管性痴呆的相关因素分析[J].中国实用神经疾病杂志,2017,20(4):57-59.
[7]余波,张晓玲,官俏兵,等.血管性痴呆和阿尔茨海默病的认知功能及精神行为比较[J].中华全科医学,2015,13(7):1204-1205.
[8]陈涛,刘凌,陈邓,等.尼莫地平治疗血管性痴呆的疗效与安全性系统评价[J].中国现代神经疾病杂志,2015,15(7):546-553.
[9]何金波,金杰.参芎葡萄糖注射液治疗血管性痴呆的疗效及对AVP的影响[J].中国实验方剂学杂志,2012,18(21):306-310.
[10]ZHONG XM, REN XC, LOU YL, et al. Effects of invitro cultured calculus bovis on learning and memory impairments of hyperlipemia vascular dementia rats[J]. J Ethnopharmacol, 2016,192(4):390-397.
[2]陈浪,王学峰.血管性痴呆病理机制研究进展[J].重庆医学,2015,44(26):3709-3711.
[3]王民.奥拉西坦联合尼莫地平治疗血管性痴呆疗效分析[J].中国实用神经疾病杂志,2014,17(14):93-95.
[4]马青,唐民科,孙文燕,等.血管性痴呆中医发病机制现代研究述要[J].中华中医药杂志,2018,33(1):212-215.
[5]曹宇,裴卉,刘美霞,等.血管性痴呆的遗传学机制研究进展[J].中国临床神经科学,2017,25(5):586-594.
[6]武胜涛,张羽,李富慧,等.缺血性脑卒中后血管性痴呆的相关因素分析[J].中国实用神经疾病杂志,2017,20(4):57-59.
[7]余波,张晓玲,官俏兵,等.血管性痴呆和阿尔茨海默病的认知功能及精神行为比较[J].中华全科医学,2015,13(7):1204-1205.
[8]陈涛,刘凌,陈邓,等.尼莫地平治疗血管性痴呆的疗效与安全性系统评价[J].中国现代神经疾病杂志,2015,15(7):546-553.
[9]何金波,金杰.参芎葡萄糖注射液治疗血管性痴呆的疗效及对AVP的影响[J].中国实验方剂学杂志,2012,18(21):306-310.
[10]ZHONG XM, REN XC, LOU YL, et al. Effects of invitro cultured calculus bovis on learning and memory impairments of hyperlipemia vascular dementia rats[J]. J Ethnopharmacol, 2016,192(4):390-397.