氧化石墨烯/丙酸氯倍他索分子捕获器的制备及性能

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英文篇名：Preparation and Properties of Clobetasol Propionate Molecular Capture Based on Graphene Oxide 作者：王芳 ; 刘敏 ; 李小燕 ; 吴宗远 ; 刘莉 ; 朱晨 英文作者：WANG Fang;LIU Min;LI Xiao-yan;WU Zong-yuan;LIU Li;ZHU Chen;Key Laboratory of Guangxi Colleges and Universities for Food Safety and Pharmaceutical Analytical Chemistry,Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, School of Chemistry and Chemical Engineering,Guangxi University for Nationalities;Guangxi Key Laboratory of Utilization of Microbial and Botanical Resources, School of Marine Sciences and Biotechnology, Guangxi University for Nationalities; 关键词：分子捕获器 ; 固相萃取 ; 丙酸氯倍他索 ; 氧化石墨烯 ; 表面印迹 ; 功能材料 英文关键词：molecular capture;;solid phase extraction;;clobetasol propionate;;grapheme oxide;;surface imprinting technique;;functional materials 中文刊名：JXHG 英文刊名：Fine Chemicals 机构：广西民族大学化学化工学院广西高校食品安全与药物分析化学重点实验室广西林产化学与工程重点实验室;广西民族大学海洋与生物技术学院广西高校微生物与植物资源利用重点实验室; 出版日期：2019-04-08 13:22 出版单位：精细化工 年：2019 期：v.36 基金：国家自然科学基金项目(21545011,21165003);; 广西自然科学基金项目(2016GXNSFAA380141);; 广西科技基地和人才专项(桂科AD18126005);; 广西民族大学科研基金项目(2017MDQN002);; 广西高校中青年教师基础能力提升项目(2018KY0169) 语种：中文; 页：JXHG201908005 页数：7 CN：08 ISSN：21-1203/TQ 分类号：31-37

摘要

以氧化石墨烯修饰聚乙烯滤板为内部支撑体,采用表面分子印迹技术,以丙酸氯倍他索为模板分子,3-氨丙基三乙氧基硅烷为功能单体,正硅酸乙酯为交联剂,在内部支撑体表面进行分子印迹,制备了一种对丙酸氯倍他索具有特异选择吸附能力的分子捕获器。分别采用FTIR、FESEM、EDS、TGA对分子捕获器的结构、形貌、热稳定性进行了表征。并对其吸附性能进行了研究,结果表明,该分子捕获器对丙酸氯倍他索具有较好的结合性能。将该分子捕获器作为固相萃取整体材料,结合高效液相色谱检测,应用于加标化妆品样品中丙酸氯倍他索的选择性富集分离,方法检出限为0.04 mg/L,准确性、精密度良好。分子捕获器可以重复使用4次,具有良好的耐用性。
        A solid phase extraction material with specificity extracting clobetasol propionate of molecular capture was prepared by surface imprinting technique in combination with solid phase extraction column sieve plate coated with graphene oxide. The molecular capture(MC) was prepared by using clobetasol propionate as template molecule, 3-aminopropyltriethoxysilane as monomer and ethyl silicate as cross-linker, respectively. The morphology, structure and thermostability of the molecular capture were characterized by FTIR, FESEM, EDS and TGA, and its adsorption properties were studied. The results showed that the molecular capture had binding performance to chlorbetasol propionate. This molecular capture was used as a solid phase extraction material, combined with HPLC detection, for the selective enrichment and separation of chlorbetasol propionate in cosmetics samples. It was found that this method had good accuracy and precision and its detection limit was 0.04 mg/L. The durability test demonstrated that the molecular capture could be reused at least 4 times with good durability.

引文

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