IL-35与人类疾病关系的研究进展
摘要
白细胞介素35(interleukin35,IL-35)是IL-12家族的新成员,是一种新型抗炎因子,不仅促进调节性T细胞(regulatory T-cell,Treg)的增殖,还可抑制辅助性T细胞17(Thelper cell 17,Th17)的分化及IL-17的分泌,从而发挥免疫抑制作用。目前研究认为,IL-35广泛参与人类各系统疾病的发生、发展,是目前新的研究热点。现将近年来有关IL-35与各系统疾病的关系作一综述。
引文
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[12]高艺伟.格林-巴利综合征患者血清IL-17及IL-35水平的变化及其临床意义[D].郑州:郑州大学,2012.
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[17]CHEN C,DENG Y,CHEN H,et al. Decreased concentration of IL-35 in plasma of patients with asthma and COPD[J].2014,32(3):211-217.
[18]袁浩,周毅峰,杨明,等.小儿支原体肺炎患者外周血中IL-35与巨噬细胞、树突状细胞水平的相关性研究[J].中国卫生检验杂志,2016(24):3543-3545.
[19]WIRTZ S,BILLMEIER U,MCHEDLIDZE T,et al. Interleukin-35 mediates mucosal immune responses that protect against t-cell-dependent colitis[J]. Gastroenterology,2011,141(5):1875-1886.
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[21]石银月,颜学兵,徐娟,等.慢性HBV感染者外周血中IL-35表达水平的检测及其意义[J].中华实验和临床感染病杂志(电子版),2012,6(3):33-36.
[22]HU Y,DONG C,YUE Y,et al. In vivo delivery of interleukin-35 relieves coxsackievirus-B3-induced viral myocarditis by inhibiting Th17 cells[J]. Arch Virol,2014,159(9):2411-2419.
[23]张传峰,苑海涛.病毒性心肌炎患者血清IL17、IL35水平变化及意义[J].山东医药,2014(31):28-30.
[24]BARRERE J M,FRANCIS B,ERCILLA G,et al. Improved detection of anti-HCV in post-transfusion hepatitis by a thirdgeneration ELISA[J]. Vox Sang,2010,68(1):15-18.
[25]罗程,吉庆伟,林英忠,等.冠心病患者血浆IL-35水平的变化及意义[J].细胞与分子免疫学杂志,2013,29(7):759-760.
[26]台适,周胜华,刘启明,等.冠心病患者血浆IL-35水平及临床意义的探讨[C].天津:中华医学会,2013.
[27]LIN Y,HUANG,LU Z,et al. Decreased plasma IL-35 levels are related to the left ventricular ejection fraction in coronary artery diseases[J]. PLo S One,2012,7(12):e52490.
[28]JIN P,REN H,SUN W,et al. Circulating IL-35 in pancreatic ductal adenocarcinoma patients[J]. Human Immunology,2014,75(1):29-33.
[29]GU X,TIAN T,ZHANG B,et al. Elevated plasma interleukin-35 levels predict poor prognosis in patients with non-small cell lung cancer[J]. Tumour Biol,2015,36(4):2651-2656.
[30]TAO Q,PAN Y,WANG Y,et al. Regulatory T cells-derived IL-35 promotes the growth of adult acute myeloid leukemia blasts[J]. Int J Cancer,2015,137(10):2384-2393.
[31]LONG J,ZHANG X,WEN M,et al. IL-35 over-expression increases apoptosis sensitivity and suppresses cell growth in human cancer cells[J]. Biochem Biophys Res Commun,2013,430(1):364-369.
[2]COLLISON L W,WORKMAN C J,KUO T T,et al. The inhibitory cytokine IL-35 contributes to regulatory T-cell function[J]. Nature,2007,450(7169):566-569.
[3]COLLISON L W,DELGOFFE G M,GUY C S,et al. The composition and signaling of the IL-35 receptor are unconventional[J]. Nat Immunol,2012,13(3):290-299.
[4] SAWANT D V,HAMILTON K,VIGNALI D A. Interleukin-35:expanding its job profile[J]. J Interferon Cytokine Res,2015,35(7):499-512.
[5]PANKRATZ S,BITTNER S,HERRMANN A M,et al. Human CD4+HLA-G+regulatory T cells are potent suppressors of graft-versus-host disease in vivo[J]. FASEB J,2014,28(8):3435-3445.
[6]DEVERGNE O,BIRKENBACH M,KIEFF E. Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin[J]. Proc Natl Acad Sci U S A,1997,94(22):12041-12046.
[7]KOCHETKOVA I,GOLDEN S,HOLDERNESS K,et al. IL-35stimulation of CD39+regulatory T cells confers protection against collagenⅡ-induced arthritis via the production of IL-10[J]. J Immunol,2010,184(12):7144-7153.
[8]KUO J,NARDELLI D T,WARNER T F,et al. Interleukin-35enhances Lyme arthritis in Borrelia-vaccinated and infected mice[J]. Clin Vaccine Immunol,2011,18(7):1125-1132.
[9]孟博,谢而付,周春刚.类风湿关节炎患者血清IL-35的水平及其与疾病活动度的关系[J].临床检验杂志,2016,34(4):277-280.
[10]粟深伟,陆进明,盛君,等.类风湿关节炎患者血清白介素-33、白介素-35表达及其临床意义[J].皖南医学院学报,2012,31(6):450-452.
[11]刘丽.多发性硬化患者血清IL-33及IL-35水平的变化及其临床意义[D].郑州:郑州大学,2013.
[12]高艺伟.格林-巴利综合征患者血清IL-17及IL-35水平的变化及其临床意义[D].郑州:郑州大学,2012.
[13]郭敏. IL-35、IL-17在慢性荨麻疹患者血清中的表达及意义[D].太原:山西医科大学,2016.
[14]寇晓丽.过敏性紫癜患者血清中IL-18、IL-33及IL-35的表达及意义[D].石家庄:河北医科大学,2014.
[15]MOLDAVER D M,BHARHANI M S,WATTIE J N,et al.Amelioration of ovalbumin-induced allergic airway disease following Der p 1 peptide immunotherapy is not associated with induction of IL-35[J]. Mucosal Immunol,2014,7(2):379-390.
[16]WHITEHEAD G S,WILSON R H,NAKANO K,et al. IL-35production by inducible costimulator(ICOS)-positive regulatory T cells reverses established IL-17-dependent allergic airways disease[J]. J Allergy Clin Immun,2012,129(1):207-215. e5.
[17]CHEN C,DENG Y,CHEN H,et al. Decreased concentration of IL-35 in plasma of patients with asthma and COPD[J].2014,32(3):211-217.
[18]袁浩,周毅峰,杨明,等.小儿支原体肺炎患者外周血中IL-35与巨噬细胞、树突状细胞水平的相关性研究[J].中国卫生检验杂志,2016(24):3543-3545.
[19]WIRTZ S,BILLMEIER U,MCHEDLIDZE T,et al. Interleukin-35 mediates mucosal immune responses that protect against t-cell-dependent colitis[J]. Gastroenterology,2011,141(5):1875-1886.
[20]李艳梅. IL-35在炎症性肠病患者血清和肠黏膜组织中的表达[D].济南:山东大学,2015.
[21]石银月,颜学兵,徐娟,等.慢性HBV感染者外周血中IL-35表达水平的检测及其意义[J].中华实验和临床感染病杂志(电子版),2012,6(3):33-36.
[22]HU Y,DONG C,YUE Y,et al. In vivo delivery of interleukin-35 relieves coxsackievirus-B3-induced viral myocarditis by inhibiting Th17 cells[J]. Arch Virol,2014,159(9):2411-2419.
[23]张传峰,苑海涛.病毒性心肌炎患者血清IL17、IL35水平变化及意义[J].山东医药,2014(31):28-30.
[24]BARRERE J M,FRANCIS B,ERCILLA G,et al. Improved detection of anti-HCV in post-transfusion hepatitis by a thirdgeneration ELISA[J]. Vox Sang,2010,68(1):15-18.
[25]罗程,吉庆伟,林英忠,等.冠心病患者血浆IL-35水平的变化及意义[J].细胞与分子免疫学杂志,2013,29(7):759-760.
[26]台适,周胜华,刘启明,等.冠心病患者血浆IL-35水平及临床意义的探讨[C].天津:中华医学会,2013.
[27]LIN Y,HUANG,LU Z,et al. Decreased plasma IL-35 levels are related to the left ventricular ejection fraction in coronary artery diseases[J]. PLo S One,2012,7(12):e52490.
[28]JIN P,REN H,SUN W,et al. Circulating IL-35 in pancreatic ductal adenocarcinoma patients[J]. Human Immunology,2014,75(1):29-33.
[29]GU X,TIAN T,ZHANG B,et al. Elevated plasma interleukin-35 levels predict poor prognosis in patients with non-small cell lung cancer[J]. Tumour Biol,2015,36(4):2651-2656.
[30]TAO Q,PAN Y,WANG Y,et al. Regulatory T cells-derived IL-35 promotes the growth of adult acute myeloid leukemia blasts[J]. Int J Cancer,2015,137(10):2384-2393.
[31]LONG J,ZHANG X,WEN M,et al. IL-35 over-expression increases apoptosis sensitivity and suppresses cell growth in human cancer cells[J]. Biochem Biophys Res Commun,2013,430(1):364-369.