子痫前期病人血清Gas6和SDF-1水平变化及意义
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摘要
目的探讨子痫前期病人血清生长停滞特异基因6(Gas6)和基质细胞衍生因子1(SDF-1)水平变化及临床意义。方法选取子痫前期病人138例,根据病情严重程度分为轻度组(n=61)和重度组(n=77),后者再根据发病时间分为早发型组(n=35)和晚发型组(n=42);同期选取正常妊娠孕妇50例为对照组。检测血清Gas6、SDF-1、超敏C-反应蛋白(hs-CRP)及炎症因子水平。结果子痫前期病人血清Gas6水平低于对照组,而SDF-1水平高于对照组(t=10.813、9.794,P<0.05);重度组病人血清Gas6水平低于轻度组,而SDF-1水平高于轻度组(t=16.978、12.499,P<0.05);重度组病人中,早发型组病人血清Gas6水平高于晚发型组,而SDF-1水平低于晚发型组(t=7.837、4.409,P<0.05)。与对照组相比,轻度组和重度组子痫前期病人血清hs-CRP、白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平均升高(t=7.967～30.849,P<0.05);与轻度组相比,重度组子痫前期病人血清hs-CRP、IL-1β、IL-6和TNF-α水平均升高(t=23.095～49.475,P<0.05)。Pearson相关分析显示,病人血清Gas6水平与hs-CRP、IL-1β、IL-6和TNF-α水平均呈负相关(r=-0.460～-0.622,P<0.05),SDF-1水平与hs-CRP、IL-1β、IL-6水平均呈正相关(r=0.315～0.505,P<0.05)。结论子痫前期病人血清中Gas6水平降低,而SDF-1水平升高,且与病人病情严重程度有关。
Objective To investigate the changes in serum levels of growth arrest-specific gene 6(Gas6)and stromal cell-derived factor 1(SDF-1)in patients with preeclampsia and their clinical significance. Methods A total of 138 patients with preeclampsia were selected and divided into mild group(n=61)and severe group(n=77)according to the severity of disease,and the latter was subdivided into early-onset group(n=35)and late-onset group(n=42)according to onset time;50 normal pregnant women from the same period were included as control group.Serum levels of Gas6,SDF-1,high-sensitivity C-reactive protein(hsCRP),and inflammatory factors were measured. Results Patients with preeclampsia had a lower serum level of Gas6 and a higher serum level of SDF-1 than the control group(t=10.813 and 9.794,respectively,both P<0.05);the severe group had a lower serum level of Gas6 and a higher serum level of SDF-1 than the mild group(t=16.978 and 12.499,respectively,both P<0.05);the early-onset group had a higher serum level of Gas6 and a lower serum level of SDF-1 than the late-onset group among patients with severe preeclampsia(t=7.837 and 4.409,respectively,both P<0.05).The mild group and the severe group had increased serum levels of hs-CRP,interleukin 1 beta(IL-1β),interleukin 6(IL-6),and tumor necrosis factor-alpha(TNF-α)compared with the control group(t=7.967-30.849,all P<0.05);the same was true for the severe group when compared with the mild group(t=23.095-49.475,all P<0.05).Pearson correlation analysis showed that the patients' serum level of Gas6 was negatively correlated with hs-CRP,IL-1β,IL-6,and TNF-α(r=-0.460 to-0.622,all P<0.05)and serum level of SDF-1 was positively correlated with hs-CRP,IL-1β,and IL-6(r=0.315 to 0.505,all P<0.05). Conclusion Patients with preeclampsia have an increased serum level of Gas6 and a decreased serum level of SDF-1,which are correlated with the severity of disease.
Objective To investigate the changes in serum levels of growth arrest-specific gene 6(Gas6)and stromal cell-derived factor 1(SDF-1)in patients with preeclampsia and their clinical significance. Methods A total of 138 patients with preeclampsia were selected and divided into mild group(n=61)and severe group(n=77)according to the severity of disease,and the latter was subdivided into early-onset group(n=35)and late-onset group(n=42)according to onset time;50 normal pregnant women from the same period were included as control group.Serum levels of Gas6,SDF-1,high-sensitivity C-reactive protein(hsCRP),and inflammatory factors were measured. Results Patients with preeclampsia had a lower serum level of Gas6 and a higher serum level of SDF-1 than the control group(t=10.813 and 9.794,respectively,both P<0.05);the severe group had a lower serum level of Gas6 and a higher serum level of SDF-1 than the mild group(t=16.978 and 12.499,respectively,both P<0.05);the early-onset group had a higher serum level of Gas6 and a lower serum level of SDF-1 than the late-onset group among patients with severe preeclampsia(t=7.837 and 4.409,respectively,both P<0.05).The mild group and the severe group had increased serum levels of hs-CRP,interleukin 1 beta(IL-1β),interleukin 6(IL-6),and tumor necrosis factor-alpha(TNF-α)compared with the control group(t=7.967-30.849,all P<0.05);the same was true for the severe group when compared with the mild group(t=23.095-49.475,all P<0.05).Pearson correlation analysis showed that the patients' serum level of Gas6 was negatively correlated with hs-CRP,IL-1β,IL-6,and TNF-α(r=-0.460 to-0.622,all P<0.05)and serum level of SDF-1 was positively correlated with hs-CRP,IL-1β,and IL-6(r=0.315 to 0.505,all P<0.05). Conclusion Patients with preeclampsia have an increased serum level of Gas6 and a decreased serum level of SDF-1,which are correlated with the severity of disease.
引文
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[13]王艳.人血白蛋白联合小剂量肝素对子痫前期患者胎盘缺血缺氧损伤的影响[J].中国妇幼保健,2018,33(4):915-917.
[14]RASHAD N M,EL-SHABRAWY R M,SABRY H M,et al.Interleukin-6and hs-CRP as early diagnostic biomarkers for obesity-related peripheral polyneuropathy in non-diabetic patients[J].Egypt J Immunol,2018,25(2):153-165.
[15]刘婷,李丹,张燕,等.骨桥蛋白及炎性因子在轻度认知障碍进展的预测价值研究[J].中国全科医学,2018,21(32):3933-3937,3945.
[16]陈立婷,卢萍,孙宇辉.Gas6/Axl信号通路与肿瘤关系的研究进展[J].现代肿瘤医学,2016,24(19):3165-3168.
[17]刘颖君,欧阳翔英,王宇光,等.生长停滞特异性蛋白6在牙龈卟啉单胞菌脂多糖诱导内皮细胞黏附因子及趋化因子表达中的作用[J].北京大学学报(医学版),2018,50(1):20-25.
[18]WANG Zhidong,SUN Jian,FENG Yeqian,et al.Oncogenic roles and drug target of CXCR4/CXCL12axis in lung cancer and cancer stem cell[J].Tumour Biology:the Journal of the International Society for Oncodevelopmental Biology and Medicine,2016,37(7):8515-8528.
[19]VILLALVILLA A,GOMEZ R,ROMAN-BLAS J A,et al.SDF-1signaling:apromising target in rheumatic diseases[J].Expert Opinion on Therapeutic Targets,2014,18(9):1077-1087.
[2]XIAO Y,SUN H,LI C,et al.Effect of iodine nutrition on pregnancy outcomes in an iodine-sufficient area in China[J].Biol Trace Elem Res,2018,182(2):231-237.
[3]FANG X,LIANG Y,CHEN D,et al.A study on clinicoradiological characteristics and pregnancy outcomes of reversible posterior leukoencephalopathy syndrome in preeclampsia or eclampsia[J].Hypertens Res,2017,40(12):982-987.
[4]DE SOUSA ROCHA V,DELLA ROSA F B,RUANO R,et al.Association between Magnesium status,oxidative stress and inflammation in preeclampsia:a case-control study[J].Clinical Nutrition(Edinburgh,Scotland),2015,34(6):1166-1171.
[5]LI Wenni,WANG Junlin,GE Lina,et al.Growth arrest-specific protein 6(Gas6)as a noninvasive biomarker for early detection of diabetic nephropathy[J].Clinical and Experimental Hypertension(New York,N Y:1993),2017,39(4):382-387.
[6]SHIBATA T,ISMAILOGLU U B,KITTAN N A,et al.Role of growth arrest-specific gene 6in the development of fungal allergic airway disease in mice[J].American Journal of Respiratory Cell and Molecular Biology,2014,51(5):615-625.
[7]ODENT GRIGORESCU G,ROSCA A M,PREDA M B,et al.Synergic effects of VEGF-A and SDF-1on the angiogenic properties of endothelial progenitor cells[J].J Tissue Eng Regen Med,2017,11(11):3241-3252.
[8]包春燕,周林裕,于晓霞,等.子痫前期胎盘和蜕膜组织中Gas6、SATB1的含量及其与氧化应激、炎性反应的相关性[J].临床和实验医学杂志,2018,17(9):949-952.
[9]朱小华,罗新.SDF-1/CXCR4与妊娠期高血压疾病关系的研究进展[J].国际妇产科学杂志,2015,42(5):524-527.
[10]中华医学会妇产科学分会妊娠期高血压疾病学组.妊娠期高血压疾病诊治指南(2012版)[J].中华妇产科杂志,2012,47(6):476-480.
[11]HONIGBERG M C,SEELY E W,THOMAS A M,et al.Infant size and the association between maternal circulating angiogenic factors and preeclampsia[J].J Perinatol,2018,38(5):456-461.
[12]SPRACKLEN C N,SAFTLAS A F,TRICHE E W,et al.Genetic predisposition to dyslipidemia and risk of preeclampsia[J].American Journal of Hypertension,2015,28(7):915-923.
[13]王艳.人血白蛋白联合小剂量肝素对子痫前期患者胎盘缺血缺氧损伤的影响[J].中国妇幼保健,2018,33(4):915-917.
[14]RASHAD N M,EL-SHABRAWY R M,SABRY H M,et al.Interleukin-6and hs-CRP as early diagnostic biomarkers for obesity-related peripheral polyneuropathy in non-diabetic patients[J].Egypt J Immunol,2018,25(2):153-165.
[15]刘婷,李丹,张燕,等.骨桥蛋白及炎性因子在轻度认知障碍进展的预测价值研究[J].中国全科医学,2018,21(32):3933-3937,3945.
[16]陈立婷,卢萍,孙宇辉.Gas6/Axl信号通路与肿瘤关系的研究进展[J].现代肿瘤医学,2016,24(19):3165-3168.
[17]刘颖君,欧阳翔英,王宇光,等.生长停滞特异性蛋白6在牙龈卟啉单胞菌脂多糖诱导内皮细胞黏附因子及趋化因子表达中的作用[J].北京大学学报(医学版),2018,50(1):20-25.
[18]WANG Zhidong,SUN Jian,FENG Yeqian,et al.Oncogenic roles and drug target of CXCR4/CXCL12axis in lung cancer and cancer stem cell[J].Tumour Biology:the Journal of the International Society for Oncodevelopmental Biology and Medicine,2016,37(7):8515-8528.
[19]VILLALVILLA A,GOMEZ R,ROMAN-BLAS J A,et al.SDF-1signaling:apromising target in rheumatic diseases[J].Expert Opinion on Therapeutic Targets,2014,18(9):1077-1087.
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