同仁乌鸡白凤丸联合紫河车对慢性病毒性肝炎患者临床效果观察
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摘要
目的:探讨同仁乌鸡白凤丸联合紫河车对慢性病毒性肝炎患者的治疗效果及患者血清TNF-α含量的影响。方法:选取2017年1月—2018年6月治疗的慢性病毒性肝炎患者76例作为研究对象,随机数字表分为对照组(n=38)和研究组(n=38)。对照组采用同仁乌鸡白凤丸治疗,研究组在对照组基础上联合紫河车治疗,2个月治疗后对患者治疗效果进行评估,比较两组临床效果、肝功能水平、中医证候积分及炎性因子水平。结果:研究组患者的临床有效率要显著高于对照组(P<0.05);研究组患者的ALT、AST、TBIL肝功能指标要明显比对照组低(P<0.05);治疗后研究组的中医症候积分显著低于对照组(P<0.05);治疗后研究组患者的炎性因子水平显著低于对照组(P<0.05)。结论:对于慢性病毒性肝炎的治疗,临床上采用同仁乌鸡白凤丸联合紫河车的治疗方案临床效果显著,能够有效改善患者的临床症状,促进HBV-DNA转阴,对患者身体的恢复具有一定的作用,临床上值得进一步推广和应用。
Objective:To investigate the effect of Tongren Wuji Baifeng Pill combined with placenta hominis on the patients with chronic viral hepatitis and the serum TNF-α content. Methods:Sixty-six patients with chronic viral hepatitis treated from 2017 January to February 2018 were enrolled. The random number table was divided into control group(n=38)and study group(n=38). The control group was treated with Tongren Wuji Baifeng Pill. The study group was treated with placenta hominis on the basis of the control group. The therapeutic effect of the patients was evaluated after 2 months of treatment. The clinical effects,liver function levels,TCM syndrome scores and inflammatory factor levels of the two groups were compared. Results:The clinical effective rate of the study group was significantly higher than that of the control group(P<0.05). The liver function indexes of ALT,AST and TBIL in the study group were significantly lower than those in the control group(P<0.05). The TCM syndrome score was significantly lower than that of the control group(P<0.05). The inflammatory factor level of the study group was significantly lower than that of the control group(P<0.05). Conclusion:For the treatment of chronic viral hepatitis,the clinical treatment of Tongren Wuji Baifeng Pill combined with placenta hominis is clinically effective,which can effectively improve the clinical symptoms of patients,promote HBV-DNA negative,and have a certain recovery to the patients' body. The role of clinical evaluation is worth further promotion and application.
Objective:To investigate the effect of Tongren Wuji Baifeng Pill combined with placenta hominis on the patients with chronic viral hepatitis and the serum TNF-α content. Methods:Sixty-six patients with chronic viral hepatitis treated from 2017 January to February 2018 were enrolled. The random number table was divided into control group(n=38)and study group(n=38). The control group was treated with Tongren Wuji Baifeng Pill. The study group was treated with placenta hominis on the basis of the control group. The therapeutic effect of the patients was evaluated after 2 months of treatment. The clinical effects,liver function levels,TCM syndrome scores and inflammatory factor levels of the two groups were compared. Results:The clinical effective rate of the study group was significantly higher than that of the control group(P<0.05). The liver function indexes of ALT,AST and TBIL in the study group were significantly lower than those in the control group(P<0.05). The TCM syndrome score was significantly lower than that of the control group(P<0.05). The inflammatory factor level of the study group was significantly lower than that of the control group(P<0.05). Conclusion:For the treatment of chronic viral hepatitis,the clinical treatment of Tongren Wuji Baifeng Pill combined with placenta hominis is clinically effective,which can effectively improve the clinical symptoms of patients,promote HBV-DNA negative,and have a certain recovery to the patients' body. The role of clinical evaluation is worth further promotion and application.
引文
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[17]何相好,郭霞,何智勇,等.不同麻醉方式对腹部手术患者术后感染与免疫功能及血清IL-6和TNF-α水平的影响研究[J].中华医院感染学杂志,2017,27(5):1074-1077.
[18]区宝珠,农媛生,张晓.紫河车对肾虚型复发性流产的治疗作用[J].中医临床研究,2018,23(2):100-102.
[19]付东升.紫河车合右归丸治疗心肾阳虚型慢性阻塞性肺疾病合并肺心病缓解期疗效观察[J].现代中西医结合杂志,2017,26(10):1093-1095.
[20]焦一鸣,王放,蒋玲霞.中医药在防治慢性病毒性肝炎中地位的变化[J].中医学报,2016,31(11):1710-1713.
[21]金拼拼,郑谊,赵晓燕,等.慢性病毒性肝炎患者居家注射干扰素后医疗废物处置的干预效果[J].中国护理管理,2017,17(2):275-278.
[22]郭起岳,吴清和,操红缨,等.乌鸡白凤丸治疗原发性痛经的实验研究[J].西北药学杂志,2016,31(5):482-485.
[23]陆小芸.B超肝静脉内径检测慢性病毒性肝炎患者的临床意义及肝静脉内径改变与肝纤维化程度的关系[J].肝脏,2016,21(3):227-228.
[24]江红霞,濮正平,李国荣,等.乌鸡白凤丸联合阿立哌唑治疗抗精神病药物所致气血两虚型女性闭经及高泌乳素症临床研究[J].中国卫生检验杂志,2017,21(3):368-370.
[25]朱琳,付万智,聂姜,等.基于微信平台的健康促进模式对慢性病毒性肝炎病人生活方式及生活质量的影响[J].护理研究,2016,30(35):4398-4401.
[26]冯向东,刘直臻,张钧稳.LC-si正相固相萃取-HPLC-MS/MS法测定乌鸡白凤丸中氯霉素残留[J].中国药师,2016,19(6):1096-1099.
[2]张旭东,董占军.复方鳖甲软肝片治疗乙肝肝纤维化临床研究概况[J].河北中医药学报,2016,31(2):62-64.
[3]hLi X,Xia L,Li T,et al.Cytokine-Mediated Immunopathogenesis of Hepatitis B Virus Infections[J].Clinical Reviews in Allergy&Immunology,2016,50(1):41-54.
[4]张丽,曾莉,曹俊岩.加味紫河车方治疗卵巢早衰临床研究[J].亚太传统医药,2017,13(7):122-124.
[5]王文清,黎林,王倩,等.补肾健脾方联合缬沙坦对慢性肾衰患者血清TNF-α和NO水平及肾功能的影响[J].中医药导报,2016,12(10):90-92.
[6]Wei X L.The relationship between serum visfatin and the progress of chronic viral hepatitis B cirrhosis[J].Eur Rev Med Pharmacol Sci,2017,21(2):297-301.
[7]胡琼,周娴芳,王超,等.推拿背腰部膀胱经穴对慢性疲劳综合征IFN-γ、TNF-α含量的影响[J].湖北中医药大学学报,2016,18(4):18-21.
[8]李桂香,刘玲玲,毛玉芳,等.丁二磺酸腺苷蛋氨酸联合地塞米松对妊娠期肝内胆汁淤积症患者肝功能及血清TNF-α,IL-12水平的影响[J].现代生物医学进展,2017,17(19):3765-3768.
[9]Mondal G,Saroha A,Bose P P,et al.Altered glycosylation,expression of serum haptoglobin and alpha-1-antitrypsin in chronic hepatitis C,hepatitis C induced liver cirrhosis and hepatocellular carcinoma patients.[J].Glycoconj J,2016,33(2):209-218.
[10]刘超权,凌迟浩,张运钦,等.补肾活血法联合肼苯哒嗪对老年心力衰竭患者血清TNF-α、NF-κB、IL-1β及临床疗效的影响[J].辽宁中医杂志,2016,43(6):1227-1230.
[11]孔薇,郑艳辉,张艳茹,等.益肾清利方对慢性肾炎肾虚湿热证患者TNF-α、IL-6、IL-10影响的研究[J].辽宁中医杂志,2017,44(5):999-1000.
[12]Ozturker C,Karagoz E,Tanoglu A.RE:Liver Shear-Wave Velocity to Diagnose Hepatic Fibrosis in Patients with Chronic Viral Hepatitis B[J].Korean Journal of Radiology,2016,17(5):822-822.
[13]尚春香,马吉成,南征,等.参芪扶正注射液联合化疗治疗进展期结肠癌的疗效以及对血清TNF-α和IL-2水平的影响[J].辽宁中医杂志,2017,44(8):1673-1675.
[14]梁炜,杨红梅,梁爱武,等.银杏叶提取物对慢性阻塞性肺疾病大鼠CRP、TNF-α的影响[J].实用医学杂志,2017,33(12):1936-1938.
[15]Liu J,Ji Y,Ai H,et al.Liver Shear-Wave Velocity and Serum Fibrosis Markers to Diagnose Hepatic Fibrosis in Patients with Chronic Viral Hepatitis B[J].Korean Journal of Radiology,2016,17(3):396-404.
[16]李希芝,马会力,傅勇,等.天智颗粒联合普拉克索对PDD患者血清TNF-α、IL-1、CRP、BDNF水平的影响[J].中国地方病防治杂志,2017,34(2):212-212.
[17]何相好,郭霞,何智勇,等.不同麻醉方式对腹部手术患者术后感染与免疫功能及血清IL-6和TNF-α水平的影响研究[J].中华医院感染学杂志,2017,27(5):1074-1077.
[18]区宝珠,农媛生,张晓.紫河车对肾虚型复发性流产的治疗作用[J].中医临床研究,2018,23(2):100-102.
[19]付东升.紫河车合右归丸治疗心肾阳虚型慢性阻塞性肺疾病合并肺心病缓解期疗效观察[J].现代中西医结合杂志,2017,26(10):1093-1095.
[20]焦一鸣,王放,蒋玲霞.中医药在防治慢性病毒性肝炎中地位的变化[J].中医学报,2016,31(11):1710-1713.
[21]金拼拼,郑谊,赵晓燕,等.慢性病毒性肝炎患者居家注射干扰素后医疗废物处置的干预效果[J].中国护理管理,2017,17(2):275-278.
[22]郭起岳,吴清和,操红缨,等.乌鸡白凤丸治疗原发性痛经的实验研究[J].西北药学杂志,2016,31(5):482-485.
[23]陆小芸.B超肝静脉内径检测慢性病毒性肝炎患者的临床意义及肝静脉内径改变与肝纤维化程度的关系[J].肝脏,2016,21(3):227-228.
[24]江红霞,濮正平,李国荣,等.乌鸡白凤丸联合阿立哌唑治疗抗精神病药物所致气血两虚型女性闭经及高泌乳素症临床研究[J].中国卫生检验杂志,2017,21(3):368-370.
[25]朱琳,付万智,聂姜,等.基于微信平台的健康促进模式对慢性病毒性肝炎病人生活方式及生活质量的影响[J].护理研究,2016,30(35):4398-4401.
[26]冯向东,刘直臻,张钧稳.LC-si正相固相萃取-HPLC-MS/MS法测定乌鸡白凤丸中氯霉素残留[J].中国药师,2016,19(6):1096-1099.