14-3-3蛋白相关研究进展
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摘要
14-3-3蛋白家族是一组高度保守的蛋白质家族,在各种真核生物中广泛存在,主要是以同源/异源二聚体的形式存在,在哺乳动物中共有7种亚型。目前,对于14-3-3蛋白的研究表明其在神经发育、细胞周期、疾病发生等生命过程中都发挥着重要作用。通过对近年来14-3-3蛋白的研究成果进行归纳总结,综述了14-3-3蛋白在蛋白质翻译后修饰、细胞周期及疾病形成等方面的最新研究进展,讨论了深入研究14-3-3蛋白的重要性。
The 14-3-3 proteins are a family of highly conserved proteins,and the proteins widely express in different eukaryotic cells.The 14-3-3 proteins are mainly in the form of homodimers or heterodimers,which include 7 isoforms in mammals.So far,the research on 14-3-3 proteins showed that it played an important role on neural development,cell cycle,disease occurrence and other life processes.By summarizing the research results of 14-3-3 proteins in recent years,this review summarized the latest research progress of 14-3-3 proteins in the post-translational modification,cell cycle and disease formation,etc,and discussed the importance of further study on 14-3-3 proteins.
The 14-3-3 proteins are a family of highly conserved proteins,and the proteins widely express in different eukaryotic cells.The 14-3-3 proteins are mainly in the form of homodimers or heterodimers,which include 7 isoforms in mammals.So far,the research on 14-3-3 proteins showed that it played an important role on neural development,cell cycle,disease occurrence and other life processes.By summarizing the research results of 14-3-3 proteins in recent years,this review summarized the latest research progress of 14-3-3 proteins in the post-translational modification,cell cycle and disease formation,etc,and discussed the importance of further study on 14-3-3 proteins.
引文
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[19] MCFERRIN M B,CHI X,CUTTER G,et al.Dysregulation of 14-3-3 proteins in neurodegenerative diseases with Lewy body or Alzheimer pathology[J].Ann Clin Transl Neurol,2017,4(7):466-477.
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[22] YOSHIDA K,YAMAGUCHI T,NATSUME T,et al.JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage[J].Nat Cell Biol,2005,7(3):278-285.
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[24] TOLEMAN C A,SCHUMACHER M A,YU S,et al.Structural basis of O-GlcNAc recognition by mammalian 14-3-3 proteins[J].Proceedings of the national academy of sciences,2018,115(23):5956-5961.
[25] DENG Y,JIANG B C,RANKIN C L,et al.Methionine sulfoxide reductase A (MsrA) mediates the ubiquitination of 14-3-3 protein isotypes in brain[J].Free radical biology and medicine,2018,129:600-607.
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[27] BULAVIN D V,HIGASHIMOTO Y,DEMIDENKO Z N,et al.Dual phosphorylation controls Cdc25 phosphatases and mitotic entry[J].Nat Cell Bio,2003,5(6):545-551.
[28] YUAN R,VOS H R,VAN ES R M,et al.Chk1 and 14-3-3 proteins inhibit atypical E2Fs to prevent a permanent cell cycle arrest[J].EMBO J,2018,37(5):e97877.
[29] LEE M H,LOZANO G.Regulation of the p53-MDM2 pathway by 14-3-3 sigma and other proteins[J].Semin Cancer Biol,2006,16(3):225-234.
[30] YANG H Y,WEN Y Y,CHEN C H,et al.14-3-3 sigma positively regulates p53 and suppresses tumor growth[J].Mol Cell Biol,2003,23(20):7096-7107.
[31] LARONGA C,YANG H Y,NEAL C,et al.Association of the cyclin-dependent kinases and 14-3-3 sigma negatively regulates cell cycle progression[J].J Biol Chem,2000,275(30):23106-23112.
[32] HERMEKING H,LENGAUER C,POLYAK K,et al.14-3-3sigma is a p53-regulated inhibitor of G2/M progression[J].Mol Cell,1997,1(1):3-11.
[33] LOTTERSBERGER F,RUBERT F,BALDO V,et al.Functions of Saccharomyces cerevisiae 14-3-3 proteins in response to DNA damage and to DNA replication stress[J].Genetics,2003,165(4):1717-1732.
[34] ENGELS K,MUZI-FALCONI M,GIANNATTASIO M,et al.14-3-3 proteins regulate exonuclease 1-dependent processing of stalled replication forks[J].PLoS Genetics,2011,7(4):1-9.
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[36] WAKABAYASHI K,UMAHARA T,HIROKAWA K,et al.14-3-3 protein sigma isoform co-localizes with phosphorylated α-synuclein in Lewy bodies and Lewy neurites in patients with Lewy body disease[J].Neuroscience letters,2018,674:171-175.
[37] RIZOU M,FRANGOU E A,MARINELI F,et al.The family of 14-3-3 proteins and specifically 14-3-3sigma are up-regulated during the development of renal pathologies[J].J Cell Mol Med,2018,22(9):4139-4149.
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[39] STOECK K,SANCHEZ-JUAN P,GAWINECKA J,et al.Cerebrospinal fluid biomarker supported diagnosis of Creutzfeldt-Jakob disease and rapid dementias:A longitudinal multicentre study over 10 years[J].Brain,2012,135(Pt 10):3051-3061.
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