脂肪干细胞向神经方向诱导分化的研究现状
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摘要
神经退行性疾病是一类以神经元退行性病变为主要特征的疾病,目前在全球范围内频发,尚无有效的治疗措施。干细胞具有自我更新和定向分化的潜能,为神经退行性疾病中大脑功能的恢复提供了新的治疗方法。脂肪干细胞是由中胚层发育而来的多潜能干细胞,在特定的生长因子和环境诱导下可以向不同的谱系分化,同时具有获取方便、容易培养的特点,因此脂肪组织来源的干细胞在治疗神经退行性疾病方面有其独特优势。本文就神经退行性疾病概况、脂肪干细胞生物学特性及向神经方向诱导分化的研究现状以综述。
Neurodegenerative diseases are common conditions globally that involve the degeneration of neurons,for which no effective curative measures are available. Stem cells have the potential to undergo self-renewal and directional differentiation,potentially providing new therapeutic method for the recovery of brain function in neurodegenerative diseases. In recent years,with the development of stem cell biology,it has been found that adipose stem cells are pluripotent stem cells that develop from the middle germ layer,which can differentiate into different lineages upon exposure to specific growth factors and environmental conditions.They have the benefits of being easily accessible to researchers and simple to culture. Therefore,adipose tissue-derived stem cells have unique advantages in treating neurodegenerative diseases. This article provides an overview of neurodegenerative diseases,the biological characteristics of adipose-derived stem cells,and the conditions for differentiating them into the components of neural systems.
Neurodegenerative diseases are common conditions globally that involve the degeneration of neurons,for which no effective curative measures are available. Stem cells have the potential to undergo self-renewal and directional differentiation,potentially providing new therapeutic method for the recovery of brain function in neurodegenerative diseases. In recent years,with the development of stem cell biology,it has been found that adipose stem cells are pluripotent stem cells that develop from the middle germ layer,which can differentiate into different lineages upon exposure to specific growth factors and environmental conditions.They have the benefits of being easily accessible to researchers and simple to culture. Therefore,adipose tissue-derived stem cells have unique advantages in treating neurodegenerative diseases. This article provides an overview of neurodegenerative diseases,the biological characteristics of adipose-derived stem cells,and the conditions for differentiating them into the components of neural systems.
引文
[1] Janca A,Aarli JA,Prilipko L,et al. WHO/WFN Survey of neurological services:a worldwide perspective[J]. J Neurol Sci,2006,247(1):29-34.
[2] Walt G.WHO's world health report 2003:shaping the future[J].BMJ,2004,328(7430):6.
[3] GBD 2015 Neurological Disorders Collaborator Group. Global,regional,and national burden of neurological disorders during1990-2015:a systematic analysis for the global burden of disease study 2015[J]. Lancet Neurol,2017,16(11),877-897.
[4] Walker LC,Diamond MI,Duff KE,et al. Mechanisms of protein seeding in neurodegenerative diseases[J]. JAMA Neurol,2013,70(3):304-310.
[5] Tamanini S,Comi GP,Corti,S. In vivo transient and partial cell reprogramming to pluripotency as a therapeutic tool for neurodegenerative diseases[J]. Mol Neurobiol,2018,55(8):6850-6862.
[6] Lo Furno D, Mannino G, Giuffrida R. Functional role of mesenchymal stem cells in the treatment of chronic neurodegenerative diseases[J]. J Cell Physiol,2018,233(5):3982-3999.
[7] Amemori T,Jendelova P,Ruzicka J,et al. Alzheimer's disease:mechanism and approach to cell therapy[J]. Int J Mol Sci,2015,16(11):26417-26451.
[8] Glavaski-Joksimovic A,Bohn MC. Mesenchymal stem cells and neuroregeneration in parkinson's disease[J]. Exp Neurol,2013,247:25-38.
[9] Chan TM, Chen JY,Ho LI, et al. ADSC therapy in neurodegenerative disorders[J]. Cell Transplant,2014,23(4-5):549-557.
[10] Dantuma E,Merchant S,Sugaya K. Stem cells for the treatment of neurodegenerative diseases[J]. Stem Cell Res Ther,2010,1(5):37.
[11] Barker RA. Stem cells and neurodegenerative diseases:where is it all going?[J] Regen Med,2012,7(6):26-31.
[12] Kim SU,Lee HJ,Kim YB. Neural stem cell-based treatment for neurodegenerative diseases[J]. Neuropathol,2013,33(5):491-504.
[13] Franco Lambert AP,Fraga Zandonai A,Bonatto D,et al.Differentiation of human adipose-derived adult stem cells into neuronal tissue:does it work?[J] Differentiation,2009,77(3):221-228.
[14] Tabatabaei Qomi R,Sheykhhasan M. Adipose-derived stromal cell in regenerative medicine:a review[J]. World J Stem Cells,2017,9(8):107-117.
[15] Garcia-Honduvilla N, Cifuentes A,Ortega MA. et al. High Sensitivity of Human Adipose Stem Cells to Differentiate into Myofibroblasts in the Presence of C. aspersa Egg Extract[J].Stem Cells Int,2017:9142493.
[16] Wystrychowski W,Patlolla B,Zhuge Y,et al. Multipotency and cardiomyogenic potential of human adipose-derived stem cells from epicardium,pericardium,and omentum[J]. Stem Cell Res Ther,2016,7(1):84.
[17] Fang Z,Yang Q,Xiong W,et al. Effect of CGRP-adenoviral vector transduction on the osteoblastic differentiation of rat adipose-derived stem cells[J]. PLoS One,2013,8(8):e72738.
[18] Kasir R,Vernekar VN,Laurencin CT. Regenerative engineering of cartilage using adipose-derived stem cells[J]. Regen Eng Transl Med,2015,1(2):42-49.
[19] Mostafavi FS,Razavi S,Mardani M. et al. Comparative study of microtubule-associated protein-2 and glial fibrillary acidic proteins during neural induction of human bone marrow mesenchymal stem cells and adipose-derived stem cells[J]. Int J Prev Med,2014,5(5):584-595.
[20] Zhang HT,Liu ZL,Yao XQ,et al. Neural differentiation ability of mesenchymal stromal cells from bone marrow and adipose tissue:a comparative study[J]. Cytotherapy,2012,14(10):1203-1214.
[21] Marei HES,El-Gamal A,Althani A,et al. Cholinergic and dopaminergic neuronal differentiation of human adipose tissue derived mesenchymal stem cells[J]. J Cell Physiol,2018,233(2):936-945.
[22] Maden,M. Retinoic acid in the development,regeneration and maintenance of the nervous system[J]. Nat Rev Neurosci,2007,8(10):755-765.
[23] Soheilifar MH,Javeri A,Amini H,et al. Generation of dopamine-secreting cells from human adipose tissue-derived stem cells in vitro[J]. Rejuvenation Res,2018,21(4):360-368.
[24] Singh M,Kakkar A,Sharma R,et al. Synergistic effect of bdnf and fgf2 in efficient generation of functional dopaminergic neurons from human mesenchymal stem cells[J]. Sci Rep,2017,7(1):10378.
[25] Razavi S,Mostafavi FS,Mardani M,et al. Effect of T3 hormone on neural differentiation of human adipose derived stem cells[J].Cell Biochem Funct,2014,32(8):702-710.
[26] Razavi S,Razavi MR,Ahmadi N,et al. Estrogen treatment enhances neurogenic differentiation of human adipose derived stem cells in vitro[J]. Iran J Basic Med Sci,2015,18(8):799-804.
[27] Jafarzadeh N,Javeri A,Khaleghi M,et al. Oxytocin improves proliferation and neural differentiation of adipose tissue-derived stem cells[J]. Neurosci Lett,2014,564:105-110.
[28]李文林,张冠宇,孙平新.干细胞研究中的化学生物学:学科交叉的新前沿[J].第二军医大学学报,2017,38(2):133-141.
[29] Park J,Lee N,Lee J,et al. Small molecule-based lineage switch of human adipose-derived stem cells into neural stem cells and functional GABAergic neurons[J]. Sci Rep, 2017, 7(1):10166.
[30] Razavi S,Razavi MR,Kheirollahi-Kouhestani M,et al. Coculture with neurotrophic factor secreting cells induced from adipose-derived stem cells:promotes neurogenic differentiation[J]. Biochem Biophys Res Commun,2013,440,381-387.
[31] Bahmani L,Taha MF,Javeri A. Coculture with embryonic stem cells improves neural differentiation of adipose tissue-derived stem cells[J]. Neuroscience,2014,272:229-239.
[32] Ji W,Zhang X,Ji L,et al. Effects of brainderived neurotrophic factor and neurotrophin3 on the neuronal differentiation of rat adiposederived stem cells[J]. Mol Med Rep,2015,12(4):4981-4988.
[33] Yang Y,Ma T,Ge J,et al. Facilitated Neural Differentiation of Adipose Tissue-Derived Stem Cells by Electrical Stimulation and Nurr-1 Gene Transduction[J]. Cell Transplantation,2016,25(6):1177-1191.
[2] Walt G.WHO's world health report 2003:shaping the future[J].BMJ,2004,328(7430):6.
[3] GBD 2015 Neurological Disorders Collaborator Group. Global,regional,and national burden of neurological disorders during1990-2015:a systematic analysis for the global burden of disease study 2015[J]. Lancet Neurol,2017,16(11),877-897.
[4] Walker LC,Diamond MI,Duff KE,et al. Mechanisms of protein seeding in neurodegenerative diseases[J]. JAMA Neurol,2013,70(3):304-310.
[5] Tamanini S,Comi GP,Corti,S. In vivo transient and partial cell reprogramming to pluripotency as a therapeutic tool for neurodegenerative diseases[J]. Mol Neurobiol,2018,55(8):6850-6862.
[6] Lo Furno D, Mannino G, Giuffrida R. Functional role of mesenchymal stem cells in the treatment of chronic neurodegenerative diseases[J]. J Cell Physiol,2018,233(5):3982-3999.
[7] Amemori T,Jendelova P,Ruzicka J,et al. Alzheimer's disease:mechanism and approach to cell therapy[J]. Int J Mol Sci,2015,16(11):26417-26451.
[8] Glavaski-Joksimovic A,Bohn MC. Mesenchymal stem cells and neuroregeneration in parkinson's disease[J]. Exp Neurol,2013,247:25-38.
[9] Chan TM, Chen JY,Ho LI, et al. ADSC therapy in neurodegenerative disorders[J]. Cell Transplant,2014,23(4-5):549-557.
[10] Dantuma E,Merchant S,Sugaya K. Stem cells for the treatment of neurodegenerative diseases[J]. Stem Cell Res Ther,2010,1(5):37.
[11] Barker RA. Stem cells and neurodegenerative diseases:where is it all going?[J] Regen Med,2012,7(6):26-31.
[12] Kim SU,Lee HJ,Kim YB. Neural stem cell-based treatment for neurodegenerative diseases[J]. Neuropathol,2013,33(5):491-504.
[13] Franco Lambert AP,Fraga Zandonai A,Bonatto D,et al.Differentiation of human adipose-derived adult stem cells into neuronal tissue:does it work?[J] Differentiation,2009,77(3):221-228.
[14] Tabatabaei Qomi R,Sheykhhasan M. Adipose-derived stromal cell in regenerative medicine:a review[J]. World J Stem Cells,2017,9(8):107-117.
[15] Garcia-Honduvilla N, Cifuentes A,Ortega MA. et al. High Sensitivity of Human Adipose Stem Cells to Differentiate into Myofibroblasts in the Presence of C. aspersa Egg Extract[J].Stem Cells Int,2017:9142493.
[16] Wystrychowski W,Patlolla B,Zhuge Y,et al. Multipotency and cardiomyogenic potential of human adipose-derived stem cells from epicardium,pericardium,and omentum[J]. Stem Cell Res Ther,2016,7(1):84.
[17] Fang Z,Yang Q,Xiong W,et al. Effect of CGRP-adenoviral vector transduction on the osteoblastic differentiation of rat adipose-derived stem cells[J]. PLoS One,2013,8(8):e72738.
[18] Kasir R,Vernekar VN,Laurencin CT. Regenerative engineering of cartilage using adipose-derived stem cells[J]. Regen Eng Transl Med,2015,1(2):42-49.
[19] Mostafavi FS,Razavi S,Mardani M. et al. Comparative study of microtubule-associated protein-2 and glial fibrillary acidic proteins during neural induction of human bone marrow mesenchymal stem cells and adipose-derived stem cells[J]. Int J Prev Med,2014,5(5):584-595.
[20] Zhang HT,Liu ZL,Yao XQ,et al. Neural differentiation ability of mesenchymal stromal cells from bone marrow and adipose tissue:a comparative study[J]. Cytotherapy,2012,14(10):1203-1214.
[21] Marei HES,El-Gamal A,Althani A,et al. Cholinergic and dopaminergic neuronal differentiation of human adipose tissue derived mesenchymal stem cells[J]. J Cell Physiol,2018,233(2):936-945.
[22] Maden,M. Retinoic acid in the development,regeneration and maintenance of the nervous system[J]. Nat Rev Neurosci,2007,8(10):755-765.
[23] Soheilifar MH,Javeri A,Amini H,et al. Generation of dopamine-secreting cells from human adipose tissue-derived stem cells in vitro[J]. Rejuvenation Res,2018,21(4):360-368.
[24] Singh M,Kakkar A,Sharma R,et al. Synergistic effect of bdnf and fgf2 in efficient generation of functional dopaminergic neurons from human mesenchymal stem cells[J]. Sci Rep,2017,7(1):10378.
[25] Razavi S,Mostafavi FS,Mardani M,et al. Effect of T3 hormone on neural differentiation of human adipose derived stem cells[J].Cell Biochem Funct,2014,32(8):702-710.
[26] Razavi S,Razavi MR,Ahmadi N,et al. Estrogen treatment enhances neurogenic differentiation of human adipose derived stem cells in vitro[J]. Iran J Basic Med Sci,2015,18(8):799-804.
[27] Jafarzadeh N,Javeri A,Khaleghi M,et al. Oxytocin improves proliferation and neural differentiation of adipose tissue-derived stem cells[J]. Neurosci Lett,2014,564:105-110.
[28]李文林,张冠宇,孙平新.干细胞研究中的化学生物学:学科交叉的新前沿[J].第二军医大学学报,2017,38(2):133-141.
[29] Park J,Lee N,Lee J,et al. Small molecule-based lineage switch of human adipose-derived stem cells into neural stem cells and functional GABAergic neurons[J]. Sci Rep, 2017, 7(1):10166.
[30] Razavi S,Razavi MR,Kheirollahi-Kouhestani M,et al. Coculture with neurotrophic factor secreting cells induced from adipose-derived stem cells:promotes neurogenic differentiation[J]. Biochem Biophys Res Commun,2013,440,381-387.
[31] Bahmani L,Taha MF,Javeri A. Coculture with embryonic stem cells improves neural differentiation of adipose tissue-derived stem cells[J]. Neuroscience,2014,272:229-239.
[32] Ji W,Zhang X,Ji L,et al. Effects of brainderived neurotrophic factor and neurotrophin3 on the neuronal differentiation of rat adiposederived stem cells[J]. Mol Med Rep,2015,12(4):4981-4988.
[33] Yang Y,Ma T,Ge J,et al. Facilitated Neural Differentiation of Adipose Tissue-Derived Stem Cells by Electrical Stimulation and Nurr-1 Gene Transduction[J]. Cell Transplantation,2016,25(6):1177-1191.