甲状腺破骨细胞样巨细胞性未分化癌临床病理及分子病理特征探析
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摘要
目的研究甲状腺破骨细胞样巨细胞性未分化癌临床病理及分子病理特征。方法选择100例德州市陵城区人民医院病理科甲状腺破骨细胞样巨细胞性未分化癌患者作为该次研究病人或研究对象(选取时间为2017年6月—2018年8月),对其实施手术切除、免疫组化染色和甲状腺基因突变检测,分析其基因突变位点。结果100例患者中,出现KRAS、NRAS、PIK3CA基因突变,突变率分别为20.00%、1.50、1.60、2.20。结论甲状腺破骨细胞样巨细胞性未分化癌为一类高度侵袭性肿瘤,预后较差,以肉瘤样改变作为组织形态学,应加以重视。
Objective To study the clinicopathological and molecular pathological features of thyroid osteoclast-like giant cell undifferentiated carcinoma. Methods A total of 100 cases of thyroid osteoclast-like giant cell undifferentiated carcinoma of the Department of Pathology, Lingcheng People's Hospital, Dezhou were selected as the patients or subjects of study(selected from June 2017 to August 2018). Excision, immunohistochemical staining and thyroid gene mutation detection were used to analyze the gene mutation sites. Results KRAS, NRAS, and PIK3CA gene mutations occurred in 100 patients, and the mutation rates were 20.00%, 1.50, 1.60, and 2.20%, respectively. Conclusion Thyroid osteoblast-like giant cell undifferentiated carcinoma is a kind of highly invasive tumor with poor prognosis. And there is sarcomatoid change in histomorphology, which should be valued.
Objective To study the clinicopathological and molecular pathological features of thyroid osteoclast-like giant cell undifferentiated carcinoma. Methods A total of 100 cases of thyroid osteoclast-like giant cell undifferentiated carcinoma of the Department of Pathology, Lingcheng People's Hospital, Dezhou were selected as the patients or subjects of study(selected from June 2017 to August 2018). Excision, immunohistochemical staining and thyroid gene mutation detection were used to analyze the gene mutation sites. Results KRAS, NRAS, and PIK3CA gene mutations occurred in 100 patients, and the mutation rates were 20.00%, 1.50, 1.60, and 2.20%, respectively. Conclusion Thyroid osteoblast-like giant cell undifferentiated carcinoma is a kind of highly invasive tumor with poor prognosis. And there is sarcomatoid change in histomorphology, which should be valued.
引文
[1]陈少华,曲利娟,曾德华,等.伴恶性软组织巨细胞肿瘤成分的甲状腺乳头状癌1例并文献复习[J].临床与实验病理学杂志,2017,33(4):442-444.
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[11]李正金,田林波,李耀康,等.胸椎透明细胞软骨肉瘤临床病理观察[J].海南医学,2017,27(8):1361-1362.
[12]巫娟,徐钢,傅静.膝关节色素沉着绒毛结节性滑膜炎的临床病理分析[J].四川医学,2017,38(9):1010-1013.
[13]Heikkila Annukka,Fermer Christian,Hagstrom Jaana,et al.A novel stem cell associated marker identified by monoclonal antibody HESC5:3 differentiates between neoplastic lesions in follicular thyroid neoplasms[J].AP-MIS:Acta Pathologica,Microbiologica et Immunologica Scandinavica,2015,123(7):604-612.
[14]黄思念,王丽梅,姚俊霞,等.甲状腺破骨细胞样巨细胞性未分化癌临床病理及分子病理特点分析[J].中国实验诊断学,2018,22(3):466-469.
[2]谭晓开,李乐,陈华,等.伴破骨细胞样巨细胞的未分化胰腺癌5例分析并文献复习[J].中国实用外科杂志,201838(5):564-568.
[3]奚丽娜,赵卫星.伴有破骨细胞样巨细胞的十二指肠未分化癌1例[J].诊断病理学杂志,2017,24(7):560-560.
[4]Pannone G,Santoro A,Pasquali D,et al.The role of survivin in thyroid tumors:Differences of expression in well-differentiated,non-well-differentiated,and anaplastic thyroid cancers[J].Thyroid:official journal of the American Thyroid Association,2014,24(3):511-519.
[5]王兴,朱一鸣,黄辉,等.伴分化型病理表现的未分化型甲状腺癌临床及预后特点分析[J].山东医药,2017,57(44):81-83.
[6]赵健,田浩,邵成浩.胰腺伴破骨样巨细胞未分化癌一例并文献复习[J].肝胆胰外科杂志,2017,29(5):422-423.
[7]于琳,朱永村,葛文敏.伴有叶状肿瘤区域及破骨巨细胞的乳腺巨大化生性癌1例[J].临床与实验病理学杂志,2017,33(8):941-943.
[8]王昀,晋薇,宋欣,等.子宫内膜未分化及去分化癌8例临床病理特点[J].诊断病理学杂志,2017,24(4):252-257.
[9]Burrows N,Telfer B,Brabant G,et al.Inhibiting the phosphatidylinositide 3-kinase pathway blocks radiation-induced metastasis associated with Rho-GTPase and Hypoxia-inducible factor-1 activity[J].Radiotherapy and oncology:Journal of the European Society for Therapeutic Radiology and Oncology,2013,108(3):548-553.
[10]王富强,谭改民.低分化甲状腺癌临床病理特征分析[J].中国全科医学,2017,20(26):3304-3308.
[11]李正金,田林波,李耀康,等.胸椎透明细胞软骨肉瘤临床病理观察[J].海南医学,2017,27(8):1361-1362.
[12]巫娟,徐钢,傅静.膝关节色素沉着绒毛结节性滑膜炎的临床病理分析[J].四川医学,2017,38(9):1010-1013.
[13]Heikkila Annukka,Fermer Christian,Hagstrom Jaana,et al.A novel stem cell associated marker identified by monoclonal antibody HESC5:3 differentiates between neoplastic lesions in follicular thyroid neoplasms[J].AP-MIS:Acta Pathologica,Microbiologica et Immunologica Scandinavica,2015,123(7):604-612.
[14]黄思念,王丽梅,姚俊霞,等.甲状腺破骨细胞样巨细胞性未分化癌临床病理及分子病理特点分析[J].中国实验诊断学,2018,22(3):466-469.
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