孕期钙营养指导对新生儿骨密度和骨代谢水平的影响
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摘要
目的探讨孕期钙营养指导对孕妇及新生儿骨密度和骨代谢水平的影响。方法选取2017年6月至2018年6月在浙江省丽水市妇幼保健院产检的孕妇221例,采用随机数字表法分为观察组(n=109)和对照组(n=112),观察组给予孕期钙营养指导,对照组给予常规孕期保健宣教,检测孕妇、新生儿骨密度及骨代谢水平。结果观察组孕妇分娩后骨密度[(1.02±0.05)g/cm~2]明显高于对照组[(0.93±0.05)g/cm~2],差异有统计学意义(t=13.38,P<0.05);观察组新生儿体质量[(3.80±0.84)kg]和骨密度[(3 010.41±68.87)m/s]明显高于对照组[(3.24±0.80)kg、(2 750.56±60.34)m/s],差异均有统计学意义(t值分别为5.08、29.86,均P<0.05)。观察组新生儿25-羟基维生素D[(19.20±3.10)ng/mL]明显高于对照组[(17.03±2.89)ng/mL],差异有统计学意义(t=5.38,P<0.05);甲状旁腺素[(88.16±21.03)pg/mL]和骨碱性磷酸酶[(180.18±34.29)U/L]均明显低于对照组[(120.03±30.41)pg/mL]、[(240.92±40.04)U/L],差异均有统计学意义(t值分别为-9.04、-12.10,均P<0.05)。结论孕期钙营养指导有助于新生儿骨骼发育,提高骨密度,改善骨代谢水平。
Objective To investigate the effect of calcium nutrition guidance during pregnancy on bone mineral density and bone metabolism in pregnant woman and newborn. Methods From June 2017 to June 2018, 221 cases of pregnant women in Maternal and Child Health-Care Center of Lishui were selected and randomly divided into observation group(n=109) and control group(n=112) by random number table. Observation group was given calcium nutrition guidance during pregnancy, and control group was given routine pregnancy health education. Bone mineral density and bone metabolism in pregnant women and newborns were detected. Results The bone mineral density of pregnant women in the observation group was significantly higher(1.02±0.05 g/cm~2) after delivery than those in the control group(0.93±0.05 g/cm~2) with statistical significance(t=13.38,P<0.05). The body mass(3.80±0.84 kg) and bone mineral density(3 010.41±68.87 m/s) of newborns in the observation group were significantly higher than those in the control group(3.24±0.80 kg, 2 750.56±60.34 m/s) with statistical significance(t value was 5.08 and 29.86, respectively, both P<0.05). In the observation group, the 25-hydroxyl vitamin D of newborns(19.20±3.10 ng/mL) was significantly higher than that in the control group(17.03±2.89 ng/mL), and the difference was significant(t=5.38,P<0.05). Parathyroid hormone(88.16±21.03 pg/ml) and bone alkaline phosphatase(180.18±34.29 U/L) were significantly lower than the control group(120.03±30.41 pg/mL, 240.92±40.04 U/L), and there were significant differences(t value was-9.04 and-12.10, respectively, both P<0.05). Conclusion Calcium nutrition guidance during pregnancy is beneficial to the development of bone, improvement of bone mineral density, and the improvement of bone metabolism in newborns.
Objective To investigate the effect of calcium nutrition guidance during pregnancy on bone mineral density and bone metabolism in pregnant woman and newborn. Methods From June 2017 to June 2018, 221 cases of pregnant women in Maternal and Child Health-Care Center of Lishui were selected and randomly divided into observation group(n=109) and control group(n=112) by random number table. Observation group was given calcium nutrition guidance during pregnancy, and control group was given routine pregnancy health education. Bone mineral density and bone metabolism in pregnant women and newborns were detected. Results The bone mineral density of pregnant women in the observation group was significantly higher(1.02±0.05 g/cm~2) after delivery than those in the control group(0.93±0.05 g/cm~2) with statistical significance(t=13.38,P<0.05). The body mass(3.80±0.84 kg) and bone mineral density(3 010.41±68.87 m/s) of newborns in the observation group were significantly higher than those in the control group(3.24±0.80 kg, 2 750.56±60.34 m/s) with statistical significance(t value was 5.08 and 29.86, respectively, both P<0.05). In the observation group, the 25-hydroxyl vitamin D of newborns(19.20±3.10 ng/mL) was significantly higher than that in the control group(17.03±2.89 ng/mL), and the difference was significant(t=5.38,P<0.05). Parathyroid hormone(88.16±21.03 pg/ml) and bone alkaline phosphatase(180.18±34.29 U/L) were significantly lower than the control group(120.03±30.41 pg/mL, 240.92±40.04 U/L), and there were significant differences(t value was-9.04 and-12.10, respectively, both P<0.05). Conclusion Calcium nutrition guidance during pregnancy is beneficial to the development of bone, improvement of bone mineral density, and the improvement of bone metabolism in newborns.
引文
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[15]陈磊,宋英凯,刘海艳,等.112名40岁以上高龄孕妇的早孕期骨密度调查[J].中国骨质疏松杂志,2017,23(3):368-370.
[16]滕志丽,贾艳芳,蒋艳纯,等.185例新生儿血清钙、磷、碱性磷酸酶与维生素D状况研究[J].重庆医学,2017,46(3):387-389.
[2]中华医学会骨质疏松和骨矿盐疾病分会.补钙和维生素D对骨骼健康的必要性[J].中华内分泌代谢杂志,2018,8(3):112-114.
[3]Yang M,Yao M A,Jia H,et al.Bone mineral density analysis in puerperium women with normal bone mineral density in early pregnancy[J].Chinese Journal of Osteoporosis,2017,6(2):45-47.
[4]巴洪冰,程亮.全身振动训练对老年女性骨密度的影响[J].中国骨质疏松杂志,2016,22(3):340-342.
[5]Liu X,Wang X,Tian Y,et al.Reduced maternal calcium intake through nutrition and supplementation is associated with adverse conditions for both the women and their infants in a Chinese population[J].Medicine (Baltimore),2017,96(18):e6609.
[6]谢燕,于群.孕期给予复方碳酸钙制剂对孕妇及新生儿骨健康的影响[J].河北医学,2013,19(11):1657-1659.
[7]侯爱军,王丽萍,赵艳敏,等.孕期膳食营养指导对母婴健康及妊娠结局的影响分析[J].中国妇产科临床杂志,2016,(3):254-256.
[8]Hanmoto T,Tabuchi Y,Ikegame M,et al.Effects of low-intensity pulsed ultrasound on osteoclasts:Analysis with goldfish scales as a model of bone[J].Biomed Res,2017,38(1):71-77.
[9]Xu J,Mojet B L,Ommen J G V,et al.The effect of Ca2+ position in zeolite Y on selective oxidation of propane at room temperature[J].Journal of Physical Chemistry B Materials Surfaces Interfaces & Biophysical,2017,108(40):15728-15734.
[10]Wang Y,Li R,Liu D,et al.Evaluation of the dietary quality by diet balance index for pregnancy among pregnant women[J].Journal of Hygiene Research,2016,45(2):211-216.
[11]Garcia A H,Erler N S,Jaddoe V W V,et al.25-hydroxyvitamin D concentrations during fetal life and bone health in children aged 6 years:a population-based prospective cohort study[J].Lancet Diabetes Endocrinol,2017,5(5):367-376.
[12]Ariyawatkul K,Lersbuasin P.Prevalence of vitamin D deficiency in cord blood of newborns and the association with maternal vitamin D status[J].Eur J Pediatr,2018,177(10):1541-1545.
[13]王玥,赵琳.孕产妇维生素D缺乏与早产的关系[J].中国妇幼健康研究,2015,26(3):638-640.
[14]Ward L M,Konji V N,Ma J.The management of osteoporosis in children[J].Osteoporos Int,2016,27(7):2147-2179.
[15]陈磊,宋英凯,刘海艳,等.112名40岁以上高龄孕妇的早孕期骨密度调查[J].中国骨质疏松杂志,2017,23(3):368-370.
[16]滕志丽,贾艳芳,蒋艳纯,等.185例新生儿血清钙、磷、碱性磷酸酶与维生素D状况研究[J].重庆医学,2017,46(3):387-389.