二十二碳六烯酸复方制剂改善小儿记忆功能的临床价值分析
|
摘要
目的:探讨二十二碳六烯酸复方制剂改善小儿记忆功能的临床价值。方法:选取某小学一到六年级的124例儿童作为研究对象,随机分为观察组和对照组(各62例)。观察组给予服用含204μg维生素、120mg大豆磷脂及200mg的二十二碳六烯酸复方制剂软胶囊,对照组给予服用含204μg维生素、120mg大豆磷脂的安慰剂软胶囊。比较两组患儿实验前后的记忆能力及安全性指标。结果:两组研究对象实验前后体重、心率及血常规情况比较差异均无统计学意义(P>0.05);两组研究对象实验前人像特点回忆、图像自由回忆、联想学习、无意义图形再认、指向记忆等各记忆量表维度评分及记忆商比较差异均无统计学意义(P>0.05),实验后观察组人像特点回忆、图像自由回忆、联想学习、无意义图形再认、指向记忆等各记忆量表维度评分及记忆商均较实验前及对照组提高(P<0.05),对照组试验后记忆量表各维度评分及记忆商与实验前比较差异均无统计学意义(P>0.05)。结论:二十二碳六烯酸复方制剂对于改善小儿记忆功能有较好的临床价值,且安全可靠。
Objective:To explore the clinical value of compound preparation of docosahexaenoic acid in improving the memory function of children.Methods:124 children from grade 1 to grade 6 of a primary school were selected in total as subjects and randomly divided into observation group and control group(62 cases each).The observation group was given 204μg vitamins,120 mg soybean phospholipids and 200 mg soft capsule of compound preparation of docosahexaenoic acid, and Control group was given 204μg vitamin,120 mg soybean phospholipids placebo soft capsules.The memory ability and indicators of safety before and after the experiment were compared between the two groups.Results:There were no significant differences in weight,heart rate and blood routine before and after the experiment between the two groups(P>0.05).There were no differences before the experimen in the scores of memorial scale dimension such as facial features recall, image free recall,associative learning,meaningless graphics recognition and pointing memory,and memory quotients between the two groups(P>0.05).After the experiment,the scores of memorial scale dimension such as facial features recall,image free recall,associative learning, meaningless graphics recognition and pointing memory,and memory quotients in the observation group were higher than those before the experiment and those in the control group(P<0.05).There were no differences in the scores of memorial scale dimension and memory quotients between the control group before and after the experiment(P>0.05).Conclusion:The compound preparation of docosahexaenoic acid has good clinical value for improving the memory function of children, and is safe and reliable.
Objective:To explore the clinical value of compound preparation of docosahexaenoic acid in improving the memory function of children.Methods:124 children from grade 1 to grade 6 of a primary school were selected in total as subjects and randomly divided into observation group and control group(62 cases each).The observation group was given 204μg vitamins,120 mg soybean phospholipids and 200 mg soft capsule of compound preparation of docosahexaenoic acid, and Control group was given 204μg vitamin,120 mg soybean phospholipids placebo soft capsules.The memory ability and indicators of safety before and after the experiment were compared between the two groups.Results:There were no significant differences in weight,heart rate and blood routine before and after the experiment between the two groups(P>0.05).There were no differences before the experimen in the scores of memorial scale dimension such as facial features recall, image free recall,associative learning,meaningless graphics recognition and pointing memory,and memory quotients between the two groups(P>0.05).After the experiment,the scores of memorial scale dimension such as facial features recall,image free recall,associative learning, meaningless graphics recognition and pointing memory,and memory quotients in the observation group were higher than those before the experiment and those in the control group(P<0.05).There were no differences in the scores of memorial scale dimension and memory quotients between the control group before and after the experiment(P>0.05).Conclusion:The compound preparation of docosahexaenoic acid has good clinical value for improving the memory function of children, and is safe and reliable.
引文
[1] 王佳,杨晓云,唐庆娟,等.二十二碳六烯酸—磷脂对AD大鼠学习记忆的影响[J].中国海洋药物,2016,35(2):59-64.
[2] 黄书才,郝伟,谌红献.二十二碳六烯酸对慢性氯胺酮暴露所致空间学习记忆损害的干预效果的行为学研究[J].中国药物依赖性杂志,2016,30(1):86-90.
[3] 高颐雄,张坚.α-亚麻酸体内转化为二十碳五烯酸和二十二碳六烯酸的研究进展[J].中国油脂,2015,40(9):27-31.
[4] 李苹,尚煜,刘雅静,等.孕期二十二碳六烯酸补充对婴儿生长发育和体质指数影响[J].中华流行病学杂志,2018,39(4):449-454.
[5] 王佳,杨晓云,唐庆娟,等.二十二碳六烯酸—磷脂对AD大鼠学习记忆的影响[J].中国海洋药物,2016,35(2):59-64.
[6] 陈鹏,邓乾春,臧茜茜,等.国内辅助改善记忆功能性食品研究进展[J].中国食品学报,2015,15(4):116-123.
[7] 蒋春闪,吕游,等.二十二碳六烯酸对脊髓损伤大鼠神经功能恢复的影响及其机制[J].山东医药,2016,56(32):32-34.
[8] Xu W,Han F,Piao W,et al.Study of DHA algal oil compound preparation on improving memory in mice[J].Wei sheng yan jiu=Journal of hygiene research,2015,44(1):86.
[9] 曾成,舒斯云,等.DHA对新生大鼠缺氧缺血性脑损伤后远期学习记忆障碍的影响[J].中华神经医学杂志,2016,15(7):678.
[10] 胡烨敏,刘笑笑,林志鹏,等.气相色谱法多重检验海豹油中二十碳五烯酸、二十二碳五烯酸和二十二碳六烯酸方法研究[J].食品安全质量检测学报,2015,37(8):2957-2966.
[11] 严彩满,吴繁,王潜,等.哺乳期新生大鼠补充不同剂量二十二碳六烯酸对其体质量增长及脂质代谢的影响[J].中华实用儿科临床杂志,2017,32(14):1089-1093.
[12] 武玉凤,黎海芪.妊娠及哺乳期补充二十二碳六烯酸微藻油对卵清蛋白致敏仔鼠的影响[J].中华儿科杂志,2017,55(9):672-677.
[13] 梁炼华,李卓强,古艳卿.毛细管气相色谱法同时检测分析鱼油中十八碳三烯酸、二十碳五烯酸和二十二碳六烯酸[J].中国卫生检验杂志,2017,27(5):632-634.
[14] 魏威,谢庆斌,等.儿童执行功能量表在中国学前儿童中的信效度分析[J].中国临床心理学杂志,2018,26(1):36.
[15] 姜柳米,刘洋,李小凤.记忆与执行筛查量表在重庆市主城区的文化常模矫正[J].重庆医科大学学报,2017,42(10):1277.
[2] 黄书才,郝伟,谌红献.二十二碳六烯酸对慢性氯胺酮暴露所致空间学习记忆损害的干预效果的行为学研究[J].中国药物依赖性杂志,2016,30(1):86-90.
[3] 高颐雄,张坚.α-亚麻酸体内转化为二十碳五烯酸和二十二碳六烯酸的研究进展[J].中国油脂,2015,40(9):27-31.
[4] 李苹,尚煜,刘雅静,等.孕期二十二碳六烯酸补充对婴儿生长发育和体质指数影响[J].中华流行病学杂志,2018,39(4):449-454.
[5] 王佳,杨晓云,唐庆娟,等.二十二碳六烯酸—磷脂对AD大鼠学习记忆的影响[J].中国海洋药物,2016,35(2):59-64.
[6] 陈鹏,邓乾春,臧茜茜,等.国内辅助改善记忆功能性食品研究进展[J].中国食品学报,2015,15(4):116-123.
[7] 蒋春闪,吕游,等.二十二碳六烯酸对脊髓损伤大鼠神经功能恢复的影响及其机制[J].山东医药,2016,56(32):32-34.
[8] Xu W,Han F,Piao W,et al.Study of DHA algal oil compound preparation on improving memory in mice[J].Wei sheng yan jiu=Journal of hygiene research,2015,44(1):86.
[9] 曾成,舒斯云,等.DHA对新生大鼠缺氧缺血性脑损伤后远期学习记忆障碍的影响[J].中华神经医学杂志,2016,15(7):678.
[10] 胡烨敏,刘笑笑,林志鹏,等.气相色谱法多重检验海豹油中二十碳五烯酸、二十二碳五烯酸和二十二碳六烯酸方法研究[J].食品安全质量检测学报,2015,37(8):2957-2966.
[11] 严彩满,吴繁,王潜,等.哺乳期新生大鼠补充不同剂量二十二碳六烯酸对其体质量增长及脂质代谢的影响[J].中华实用儿科临床杂志,2017,32(14):1089-1093.
[12] 武玉凤,黎海芪.妊娠及哺乳期补充二十二碳六烯酸微藻油对卵清蛋白致敏仔鼠的影响[J].中华儿科杂志,2017,55(9):672-677.
[13] 梁炼华,李卓强,古艳卿.毛细管气相色谱法同时检测分析鱼油中十八碳三烯酸、二十碳五烯酸和二十二碳六烯酸[J].中国卫生检验杂志,2017,27(5):632-634.
[14] 魏威,谢庆斌,等.儿童执行功能量表在中国学前儿童中的信效度分析[J].中国临床心理学杂志,2018,26(1):36.
[15] 姜柳米,刘洋,李小凤.记忆与执行筛查量表在重庆市主城区的文化常模矫正[J].重庆医科大学学报,2017,42(10):1277.