西咪替丁治疗轮状病毒肠炎的临床探讨
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摘要
目的探讨西咪替丁治疗轮状病毒肠炎的临床疗效。方法收集2017年5月~2018年5月本院儿科住院部住院治疗的轮状病毒肠炎患者63例为研究对象,按照随机数字法分为对照组和观察组。对照组行常规基础治疗,观察组患儿在常规治疗基础上予以西咪替丁静脉滴注治疗,对比分析两组患者的临床控制率及症状平均消失时间。结果对照组的临床治疗控制率相较观察组患者明显较低,存在显著差异(P<0.05);且对照组患者的临床症状平均消失时间相较观察组均明显较慢,存在显著差异(P<0.05)。结论通过对轮状病毒肠炎患儿行西咪替丁药物治疗,能够起到有效的临床疗效及疾病控制率,提高患者的细胞免疫功能抵抗轮状病毒,有效防止或者抑制病毒复制,且提高患者临床疾病症状恢复速率,可以在临床中推广应用。
Objective To analyze the clinical efficacy of cimetidine in the treatment of rotavirus enteritis. Methods A total of 63 patients with rotavirus enteritis who were hospitalized in the pediatric inpatient department from May 2017 to May 2018 were enrolled in the study. They were divided into control group and observation group according to random number method. The control group underwent routine basic treatment. The children in the observation group were treated with cimetidine intravenously on the basis of conventional treatment. The clinical control rate and the average disappearance time of the symptoms were compared between the two groups. Results The clinical control rate of the control group was significantly lower than that of the observation group, with significant difference(P<0.05). The mean disappearance time of the clinical symptoms in the control group was significantly lower than that of the observation group, and there was a significant difference(P<0.05). Conclusion The treatment of cimetidine in children with rotavirus enteritis can effectively improve the clinical efficacy and disease control rate, and improve the patients' cellular immune function against rotavirus, which effectively prevents or inhibit viral replication, and improve the recovery rate of clinical disease symptom in patients, which can be promoted and applied in the clinic.
Objective To analyze the clinical efficacy of cimetidine in the treatment of rotavirus enteritis. Methods A total of 63 patients with rotavirus enteritis who were hospitalized in the pediatric inpatient department from May 2017 to May 2018 were enrolled in the study. They were divided into control group and observation group according to random number method. The control group underwent routine basic treatment. The children in the observation group were treated with cimetidine intravenously on the basis of conventional treatment. The clinical control rate and the average disappearance time of the symptoms were compared between the two groups. Results The clinical control rate of the control group was significantly lower than that of the observation group, with significant difference(P<0.05). The mean disappearance time of the clinical symptoms in the control group was significantly lower than that of the observation group, and there was a significant difference(P<0.05). Conclusion The treatment of cimetidine in children with rotavirus enteritis can effectively improve the clinical efficacy and disease control rate, and improve the patients' cellular immune function against rotavirus, which effectively prevents or inhibit viral replication, and improve the recovery rate of clinical disease symptom in patients, which can be promoted and applied in the clinic.
引文
[1]崔艳芳.中药灌肠辅助喜炎平联合西咪替丁治疗小儿轮状病毒性肠炎疗效及对血清相关因子的影响[J].现代中西医结合杂志,2017,26(14):1573-1574.
[2]杨慧,吴莹,朱航.西咪替丁对小儿轮状病毒肠炎的临床疗效分析[J].国际病毒学杂志,2016,23(4):271-273.
[3]甘盛兴,林鸿胜,赵春妹.消旋卡多曲联合西咪替丁治疗小儿轮状病毒肠炎疗效观察[J].海南医学,2016,27(7):1165-1166.
[4]邓永洪,殷俊美,刘红霞,等.西咪替丁对轮状病毒肠炎患儿血清IL-2、TNF-α的影响[J].海南医学,2015,26(7):961-962.
[5]陆志明.西咪替丁治疗轮状病毒肠炎患儿疗效观察[J].胃肠病学和肝病学杂志,2014,23(7):792-794.
[6]张小霞.热毒宁联合西咪替丁治疗婴幼儿轮状病毒性肠炎疗效分析[J].基层医学论坛,2016,20(34):4772-4773.
[7]梁金松.西咪替丁联合炎琥宁治疗小儿轮状病毒性肠炎的疗效观察[J].临床合理用药杂志,2015,12(8):61-62.
[8]钱丽芳,郁胜华,周兰.热毒宁注射液联合西咪替丁治疗婴幼儿轮状病毒性肠炎的循证护理[J].检验医学与临床,2014,9(1):124-125.
[9]蔚宝萍.更昔洛韦联合西咪替丁治疗儿童轮状病毒性肠炎的疗效观察[J].中国现代药物应用,2015,4(9):106-107.
[10]傅洪瑞.西咪替丁联合炎琥宁治疗小儿轮状病毒性肠炎疗效观察[J].中国卫生标准管理,2015,20(6):104-105.
[11]冯勇.西咪替丁联用思密达治疗婴幼儿轮状病毒肠炎33例疗效观察[J].中国中西医结合儿科学,2014,27(4):351-352.
[12]周静.探讨更昔洛韦联用西咪替丁治疗儿童轮状病毒性肠炎的临床疗效及其安全性[J].延边医学,2015,37(13):81.
[13]梁木清.西米替丁联合喜炎平治疗小儿轮状病毒肠炎疗效分析[J].中国现代药物应用,2016,10(9):129-130.
[14]咸阳.喜炎平联合西米替丁治疗小儿轮状病毒肠炎的效果观察[J].中国实用医刊,2016,43(22):118-119.
[15]梁景林,杨学群,李少光.不同方案联合液体疗法治疗小儿轮状病毒感染性腹泻的疗效和安全性比较[J].中国现代药物应用,2014, 10(8):9-10.
[16]赵汝勤.西咪替丁与干扰素联合微量元素锌在小儿轮状病毒感染性腹泻中的应用疗效分析[J].中国医药科学,2017,7(8):40-42.
[17]鄢富贵,张丽丽.西咪替丁、干扰素联合补锌治疗小儿轮状病毒感染性腹泻的有效性及安全性分析[J].现代医院,2016,16(12):1753-1754.
[18]尹静.喜炎平联合西咪替丁在小儿病毒性肠炎抗病毒及抗炎效果分析[J].当代医学,2017,23(19):76-78.
[2]杨慧,吴莹,朱航.西咪替丁对小儿轮状病毒肠炎的临床疗效分析[J].国际病毒学杂志,2016,23(4):271-273.
[3]甘盛兴,林鸿胜,赵春妹.消旋卡多曲联合西咪替丁治疗小儿轮状病毒肠炎疗效观察[J].海南医学,2016,27(7):1165-1166.
[4]邓永洪,殷俊美,刘红霞,等.西咪替丁对轮状病毒肠炎患儿血清IL-2、TNF-α的影响[J].海南医学,2015,26(7):961-962.
[5]陆志明.西咪替丁治疗轮状病毒肠炎患儿疗效观察[J].胃肠病学和肝病学杂志,2014,23(7):792-794.
[6]张小霞.热毒宁联合西咪替丁治疗婴幼儿轮状病毒性肠炎疗效分析[J].基层医学论坛,2016,20(34):4772-4773.
[7]梁金松.西咪替丁联合炎琥宁治疗小儿轮状病毒性肠炎的疗效观察[J].临床合理用药杂志,2015,12(8):61-62.
[8]钱丽芳,郁胜华,周兰.热毒宁注射液联合西咪替丁治疗婴幼儿轮状病毒性肠炎的循证护理[J].检验医学与临床,2014,9(1):124-125.
[9]蔚宝萍.更昔洛韦联合西咪替丁治疗儿童轮状病毒性肠炎的疗效观察[J].中国现代药物应用,2015,4(9):106-107.
[10]傅洪瑞.西咪替丁联合炎琥宁治疗小儿轮状病毒性肠炎疗效观察[J].中国卫生标准管理,2015,20(6):104-105.
[11]冯勇.西咪替丁联用思密达治疗婴幼儿轮状病毒肠炎33例疗效观察[J].中国中西医结合儿科学,2014,27(4):351-352.
[12]周静.探讨更昔洛韦联用西咪替丁治疗儿童轮状病毒性肠炎的临床疗效及其安全性[J].延边医学,2015,37(13):81.
[13]梁木清.西米替丁联合喜炎平治疗小儿轮状病毒肠炎疗效分析[J].中国现代药物应用,2016,10(9):129-130.
[14]咸阳.喜炎平联合西米替丁治疗小儿轮状病毒肠炎的效果观察[J].中国实用医刊,2016,43(22):118-119.
[15]梁景林,杨学群,李少光.不同方案联合液体疗法治疗小儿轮状病毒感染性腹泻的疗效和安全性比较[J].中国现代药物应用,2014, 10(8):9-10.
[16]赵汝勤.西咪替丁与干扰素联合微量元素锌在小儿轮状病毒感染性腹泻中的应用疗效分析[J].中国医药科学,2017,7(8):40-42.
[17]鄢富贵,张丽丽.西咪替丁、干扰素联合补锌治疗小儿轮状病毒感染性腹泻的有效性及安全性分析[J].现代医院,2016,16(12):1753-1754.
[18]尹静.喜炎平联合西咪替丁在小儿病毒性肠炎抗病毒及抗炎效果分析[J].当代医学,2017,23(19):76-78.