血浆游离脂肪酸水平在心血管疾病中诊断价值
摘要
目的探讨游离脂肪酸(FFA)水平与心血管疾病相关性及其临床诊断价值。方法分别比较不同类型的冠心病患者中FFA水平,探讨FFA与不同类型冠心病的相关性。结果冠心病组中FFA水平在多支病变组中(0. 76±0. 56) mmol/L大于单支病变组(0. 65±0. 38) mmol/L和两支病变组(0. 61±0. 41) mmol/L,三亚组间比较有统计学意义(P <0. 05)。多元Logistic逐步回归分析中发现,FFA是急性心肌梗死的独立危险因素(P <0. 05)。结论血浆FFA是心肌梗死型冠心病独立危险因素之一,可作为一项独立的生化指标对心肌梗死进行初步的辅助诊断。
引文
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[12]Bhardwaj A,Truong QA,Peacock WF,et al. A multicenter comparison of established and emerging cardiac biomarkers for the diagnostic evaluation of chest pain in the emergency department[J]. Am Heart J,2011,162(2):276-282.
[2]陈效琴,任静.游离脂肪酸、胰岛素抵抗与代谢综合征相关因素的关系[J].检验医学,2016,31(7):553-558.
[3]Pilz S,Scharnagl H,Tiran B,et al. Elevated plasma free fatty acids predict sudden cardiac death:a 6. 85-year follow-up of 3315 patients after coronary angiography[J]. Euro Heart J,2007,28(22):2763-2769.
[4]Cheng TO. The current state of cardiology in China[J]. Inter J Cardiol,2004,96(3):425.
[5]Huber AH,Kampf JP,Kwan T,et al. Usefulness of serum unbound free fatty acid levels to predict death early in patients with ST-segment elevation myocardial infarction(from the Thrombolysis In Myocardial Infarction[TIMI]II trial)[J]. Ame J Cardi,2014,113(2):279-284.
[6]Pilz S,Scharnag H,Tiran B,et al. Free fatty acids are independently associated with all-cause and cardiovascular mortality in subjects with coronary artery disease[J]. J Clin Endocri&Metabo,2006,91(7):2542.
[7]Steinberg HO,Paradisi G,Hook G,et al. Free fatty acid elevation impairs insulin-mediated vasodilation and nitric oxide production[J]. Diabetes,2000,49(7):1231-1238.
[8]Peterson JT,Li H,Dillon L,et al. Evolution of matrix metalloprotease and tissue inhibitor expression during heart failure progression in the infarcted rat[J]. Cardio Res,2000,46(2):307-315.
[9]Giedd KN,Bergmann SR. Fatty acid imaging of the heart[J]. Curr Cardio Repo,2011,13(2):121-131.
[10]Prihandoko R,Alvarezcurto E,Hudson BD,et al. Distinct phosphorylation clusters determine the signaling outcome of free fatty acid receptor 4/G protein-coupled receptor 120[J]. Molec Pharma,2016,89(5):505-520.
[11]Gambert S,Vergely C,Filomenko R,et al. Adverse effects of free fatty acid associated with increased oxidative stress in postischemic isolated rat hearts[J]. Molec&Cell Bioche,2006,283(1-2):147-152.
[12]Bhardwaj A,Truong QA,Peacock WF,et al. A multicenter comparison of established and emerging cardiac biomarkers for the diagnostic evaluation of chest pain in the emergency department[J]. Am Heart J,2011,162(2):276-282.