Foxi蛋白对第1、2鳃弓衍生物的发育调节
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摘要
第1、2鳃弓是胚胎发育过程中的重要结构,可分化为颅面骨骼、耳等结构。鳃弓发育异常可导致斑马鱼、大鼠等动物产生颅面、耳等结构畸形。Forkhead(Fox)蛋白家族是胚胎发育过程中的关键转录因子,该家族中Foxi在胚胎内外胚层的不同时期有相应程度的表达,foxi1基因突变斑马鱼存在颚骨、耳板缺失及鳃弓神经嵴细胞凋亡增加等异常,Foxi1突变大鼠、狗等动物中也有相似异常。Foxi蛋白可能通过先驱因子作用调节早期胚胎发育过程中相关基因的表达,影响整个胚胎颅面结构的形成。
The first and second branchial arches are important structures in the period of embryonic development,which could differentiated into craniofacial skeleton,ear and other tissues. Abnormal branchial arches cause craniofacial,ear malformations in zebrafish,mice and other animals. Forkhead(Fox)protein family is critical transcription factors for formation of embryo,the Foxi protein expressed in embryo ectoderm and endoderm in different stages. The foxi1 mutant zebrafish display defects in otic placode and the jaw,followed by increased apoptosis of neural crest cells in arches,similar abnormities were observed in Foxi mutant mice or dogs. Foxi protein could be pioneer factors that regulate the expression of early embryonic genes,and then influence the evolution of diverse craniofacial skeleton.
The first and second branchial arches are important structures in the period of embryonic development,which could differentiated into craniofacial skeleton,ear and other tissues. Abnormal branchial arches cause craniofacial,ear malformations in zebrafish,mice and other animals. Forkhead(Fox)protein family is critical transcription factors for formation of embryo,the Foxi protein expressed in embryo ectoderm and endoderm in different stages. The foxi1 mutant zebrafish display defects in otic placode and the jaw,followed by increased apoptosis of neural crest cells in arches,similar abnormities were observed in Foxi mutant mice or dogs. Foxi protein could be pioneer factors that regulate the expression of early embryonic genes,and then influence the evolution of diverse craniofacial skeleton.
引文
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[18]Yan J,Xu L,Crawford G,et al.The forkhead transcription factor Fox I1 remains bound to condensed mitotic chromosomes and stably remodels chromatin structure[J].Mol Cell Biol,2006,26(1):155-168.
[19]Haworth KE,Healy C,Morgan P,et al.Regionalisation of early head ectoderm is regulated by endoderm and prepatterns the orofacial epithelium[J].Development,2004,131(19):4797-4806.
[20]Haworth KE,Wilson JM,Grevellec A,et al.Sonic hedgehog in the pharyngeal endoderm controls arch pattern via regulation of Fgf8 in head ectoderm[J].Dev Biol,2007,303(1):244-258.
[21]Robbins JR,Mc Guire PG,Wehrle-Haller B,et al.Diminished matrix metalloproteinase 2(MMP-2)in ectomesenchymederived tissues of the Patch mutant mouse:regulation of MMP-2by PDGF and effects on mesenchymal cell migration[J].Dev Biol,1999,212(2):255-263.
[2]Lai E,Prezioso VR,Smith E,et al.HNF-3A,a hepatocyteenriched transcription factor of novel structure is regulated transcriptionally[J].Genes Dev,1990,4(8):1427-1436.
[3]Weigel D,Jackle H.The fork head domain:a novel DNA binding motif of eukaryotic transcription factors?[J].Cell,1990,63(3):455-456.
[4]Seoane J,Le HV,Shen L,et al.Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation[J].Cell,2004,117(2):211-223.
[5]Blount AL,Schmidt K,Justice NJ,et al.Fox L2 and Smad3coordinately regulate follistatin gene transcription[J].J Biol Chem,2009,284(12):7631-7645.
[6]Calnan DR,Brunet A.The Fox O code[J].Oncogene,2008,27(16):2276-2288.
[7]Khatri SB,Edlund RK,Groves AK.Foxi3 is necessary for the induction of the chick otic placode in response to FGF signaling[J].Dev Biol,2014,391(2):158-169.
[8]Nissen RM,Yan J,Amsterdam A,et al.Zebrafish foxi one modulates cellular responses to Fgf signaling required for the integrity of ear and jaw patterning[J].Development,2003,130(11):2543-2554.
[9]Ohyama T,Groves AK.Expression of mouse Foxi class genes in early craniofacial development[J].Dev Dyn,2004,231(3):640-646.
[10]Edlund RK,Birol O,Groves AK.The role of foxi family transcription factors in the development of the ear and jaw[J].Curr Top Dev Biol,2015,111:461-495.
[11]Drogemuller C,Karlsson EK,Hytonen MK,et al.A mutation in hairless dogs implicates FOXI3 in ectodermal development[J].Science,2008,321(5895):1462.
[12]Shirokova V,Jussila M,Hytonen MK,et al.Expression of Foxi3is regulated by ectodysplasin in skin appendage placodes[J].Dev Dyn,2013,242(6):593-603.
[13]Wiener DJ,Gurtner C,Panakova L,et al.Clinical and histological characterization of hair coat and glandular tissue of Chinese crested dogs[J].Vet Dermatol,2013,24(2):274-e262.
[14]Tassano E,Jagannathan V,Drogemuller C,et al.Congenital aural atresia associated with agenesis of internal carotid artery in a girl with a FOXI3 deletion[J].Am J Med Genet A,2015,167a(3):537-544.
[15]O'Brien DP,Johnson GS,Schnabel RD,et al.Genetic mapping of canine multiple system degeneration and ectodermal dysplasia loci[J].J Hered,2005,96(7):727-734.
[16]Singh S,Groves AK.The molecular basis of craniofacial placode development[J].Wiley Interdiscip Rev Dev Biol,2016,5(3):363-376.
[17]Zaret KS,Carroll JS.Pioneer transcription factors:establishing competence for gene expression[J].Genes Dev,2011,25(21):2227-2241.
[18]Yan J,Xu L,Crawford G,et al.The forkhead transcription factor Fox I1 remains bound to condensed mitotic chromosomes and stably remodels chromatin structure[J].Mol Cell Biol,2006,26(1):155-168.
[19]Haworth KE,Healy C,Morgan P,et al.Regionalisation of early head ectoderm is regulated by endoderm and prepatterns the orofacial epithelium[J].Development,2004,131(19):4797-4806.
[20]Haworth KE,Wilson JM,Grevellec A,et al.Sonic hedgehog in the pharyngeal endoderm controls arch pattern via regulation of Fgf8 in head ectoderm[J].Dev Biol,2007,303(1):244-258.
[21]Robbins JR,Mc Guire PG,Wehrle-Haller B,et al.Diminished matrix metalloproteinase 2(MMP-2)in ectomesenchymederived tissues of the Patch mutant mouse:regulation of MMP-2by PDGF and effects on mesenchymal cell migration[J].Dev Biol,1999,212(2):255-263.