癌症发生发展中的表观遗传学研究
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摘要
癌症是由细胞恶性增殖和扩散引发的一类复杂疾病,解析其致病机制是人类目前面临的重大挑战之一。表观遗传学机制对维持基因特定的表达模式和生命个体的正常发育生长至关重要。表观遗传图谱的紊乱如组蛋白修饰、DNA/RNA甲基化和染色质三维构象的变化等均能在一定程度上干扰正常基因的表达和功能,进而诱导癌症等多种疾病的发生发展。为促进对表观遗传学在癌症中作用机制的理解,本文概述了表观遗传学研究内容,聚焦其与癌症发生发展之间的关联,同时展望了表观遗传学在癌症临床诊治中的应用。
Cancer is a complex disease caused by the malignant cellular proliferation and metastasis. Elucidating its pathogenic mechanism is one of the major challenges that we face currently. Epigenetic mechanisms are essential for maintaining specific patterns of gene expression and normal development and growth of living individuals. Disorders of epigenetic markers, such as histone modification, DNA/RNA methylation, and changes in the three-dimensional conformation of chromatin, can interfere with gene expression to some extent, and result in cancers. This review provides a brief overview of epigenetics, focusing on their association with the genesis of cancers, and we look forward to the application of epigenetics in cancer clinical diagnosis and treatment.
Cancer is a complex disease caused by the malignant cellular proliferation and metastasis. Elucidating its pathogenic mechanism is one of the major challenges that we face currently. Epigenetic mechanisms are essential for maintaining specific patterns of gene expression and normal development and growth of living individuals. Disorders of epigenetic markers, such as histone modification, DNA/RNA methylation, and changes in the three-dimensional conformation of chromatin, can interfere with gene expression to some extent, and result in cancers. This review provides a brief overview of epigenetics, focusing on their association with the genesis of cancers, and we look forward to the application of epigenetics in cancer clinical diagnosis and treatment.
引文
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