无创呼吸机联合常规药物对重症哮喘的治疗效果
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摘要
目的探讨无创呼吸机联合常规药物治疗重症哮喘的效果分析。方法将2017年9月至2018年9月在本院ICU治疗的84例重症哮喘患者随机分为两组,每组42例。对照组使用常规内科药物治疗,观察组在此基础上加用无创呼吸机治疗,比较两组患者的临床疗效、血气分析及肺功能指标变化、症状评分变化。结果观察组患者治疗有效率为92.86%,明显高于对照组的71.43%,差异有统计学意义(P<0.05);其中观察组显效率明显高于对照组,无效率明显低于对照组,差异均有统计学意义(均P<0.05)。治疗后观察组与对照组氧分压(PaO_2)、氧饱和度(SaO_2)、1秒用力呼吸容积(FEV1)、FEV1/用力肺活量(FVC)水平明显高于治疗前,PaCO_2水平明显低于治疗前,差异均有统计学意义(均P<0.05);治疗后观察组PaO_2、SaO_2、FEV1、FEV1/FVC水平明显高于对照组,PaCO_2水平明显低于对照组,差异均有统计学意义(均P<0.05)。治疗后观察组与对照组患者哮喘评分均明显低于治疗前,差异均有统计学意义(均P<0.05);治疗后观察组患者哮喘评分明显低于对照组,差异有统计学意义(P<0.05)。结论无创呼吸机联合常规药物治疗重症哮喘的效果显著,能有效提高血氧含量,改善低氧血症和CO_2潴留,促进肺功能的恢复,快速改善症状,具有积极临床意义。
Objective To investigate the effect of non-invasive ventilator combined with conventional drugs in the treatment of severe asthma.Methods 84 patients with severe asthma who were treated in ICU of our hospital from September2017 to September 2018 were randomly divided into two groups 42 cases in each group. The control group was treated with conventional internal medicine. On this basis,the observation group was treated with non-invasive ventilator. Results The effective rate of the observation group( 92.86%) was higher than that of the control group( 71.43%),the difference was statistioally significant( P<0.05). The significant efficiency of the observation group was significantly higher than that of the control group,and the inefficiency was significantly lower than that of the control group( P< 0.05). After treatment,the levels of PaO_2,SaO_2,FEV1,FEV1/FVC in the observation group and the control group were significantly higher than those before treatment,and the levels of PaCO_2 were significantly lower than those before treatment( P<0.05); after treatment,the levels of PaO_2,SaO_2,FEV1 and FEV1/FVC in the observation group were significantly higher than those in the control group,and the levels of PaCO_2 were significantly lower than those in the control group,with statistical differences significance( P<0.05). After treatment,the asthma scores of the patients in the observation group and the control group were significantly lower than those before treatment( P<0.05); after treatment,the asthma scores of the patients in the observation group were significantly lower than those in the control group( P< 0.05). Conclusion Non-invasive ventilator combined with conventional drugs has a significant effect on the treatment of severe asthma,which can effectively increase the blood oxygen content,improve hypoxemia and CO_2 retention,promote the recovery of lung function,rapidly improve symptoms,and has positive clinical significance.
Objective To investigate the effect of non-invasive ventilator combined with conventional drugs in the treatment of severe asthma.Methods 84 patients with severe asthma who were treated in ICU of our hospital from September2017 to September 2018 were randomly divided into two groups 42 cases in each group. The control group was treated with conventional internal medicine. On this basis,the observation group was treated with non-invasive ventilator. Results The effective rate of the observation group( 92.86%) was higher than that of the control group( 71.43%),the difference was statistioally significant( P<0.05). The significant efficiency of the observation group was significantly higher than that of the control group,and the inefficiency was significantly lower than that of the control group( P< 0.05). After treatment,the levels of PaO_2,SaO_2,FEV1,FEV1/FVC in the observation group and the control group were significantly higher than those before treatment,and the levels of PaCO_2 were significantly lower than those before treatment( P<0.05); after treatment,the levels of PaO_2,SaO_2,FEV1 and FEV1/FVC in the observation group were significantly higher than those in the control group,and the levels of PaCO_2 were significantly lower than those in the control group,with statistical differences significance( P<0.05). After treatment,the asthma scores of the patients in the observation group and the control group were significantly lower than those before treatment( P<0.05); after treatment,the asthma scores of the patients in the observation group were significantly lower than those in the control group( P< 0.05). Conclusion Non-invasive ventilator combined with conventional drugs has a significant effect on the treatment of severe asthma,which can effectively increase the blood oxygen content,improve hypoxemia and CO_2 retention,promote the recovery of lung function,rapidly improve symptoms,and has positive clinical significance.
引文
[1]罗惠玲,黄祥云,赵静山.无创呼吸机联合药物治疗对重症哮喘患者疗效及肺功能的影响[J].实用临床医药杂志,2016,20(17):38-40.
[2]韩桂荣.无创呼吸机与氧气驱动雾化联合治疗重症支气管哮喘92例[J].中国医药科学,2012,2(6):179-182.
[3]宋春伟.无创呼吸机联合药物治疗对重症哮喘患者的效果及肺功能的影响[J].中国疗养医学,2018,27(4):398-399.
[4]徐建萍.无创呼吸机联合普米克令舒在治疗重症支气管哮喘中的价值[J].陕西医学杂志,2015,44(4):461-462.
[5]柯颜基.无创呼吸机CPAP模式间断联合普米克令舒雾化吸入治疗重症支气管哮喘患者20例[J].吉林医学,2011,32(6):1091-1093.
[6]邹小娟.无创呼吸机辅助常规药物治疗重症哮喘的临床疗效[J].深圳中西医结合杂志,2018,28(8):169-170.
[7]肖维庆,刘湘樱,邢焕略.无创呼吸机辅助常规药物治疗重症哮喘的疗效及对肺功能的影响[J].广州医药,2018,49(3):88-90.
[2]韩桂荣.无创呼吸机与氧气驱动雾化联合治疗重症支气管哮喘92例[J].中国医药科学,2012,2(6):179-182.
[3]宋春伟.无创呼吸机联合药物治疗对重症哮喘患者的效果及肺功能的影响[J].中国疗养医学,2018,27(4):398-399.
[4]徐建萍.无创呼吸机联合普米克令舒在治疗重症支气管哮喘中的价值[J].陕西医学杂志,2015,44(4):461-462.
[5]柯颜基.无创呼吸机CPAP模式间断联合普米克令舒雾化吸入治疗重症支气管哮喘患者20例[J].吉林医学,2011,32(6):1091-1093.
[6]邹小娟.无创呼吸机辅助常规药物治疗重症哮喘的临床疗效[J].深圳中西医结合杂志,2018,28(8):169-170.
[7]肖维庆,刘湘樱,邢焕略.无创呼吸机辅助常规药物治疗重症哮喘的疗效及对肺功能的影响[J].广州医药,2018,49(3):88-90.