betatrophin在阻塞性睡眠呼吸暂停低通气综合征患者血浆中的水平及临床意义

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英文篇名：Plasma levels of betatrophin in patients with obstructive sleep apnea hypopnea syndrome and its clinical significance 作者：宋晓飞 ; 王荣国 ; 张云龙 ; 陈红耀 英文作者：SONG Xiaofei;WANG Rongguo;ZHANG Yunlong;CHEN Hongyao;Department of Otolaryngology,Hebei People's Hospital;Department of Intensive Care Unit,the First Hospital of Shijiazhuang City; 关键词：睡眠呼吸暂停 ; 阻塞性 ; betatrophin 英文关键词：Sleep Apnea,Obstructive;;betatrophin 中文刊名：EBYT 英文刊名：Chinese Archives of Otolaryngology-Head and Neck Surgery 机构：河北省人民医院耳鼻咽喉科;石家庄市第一医院重症医学科; 出版日期：2019-06-28 出版单位：中国耳鼻咽喉头颈外科 年：2019 期：v.26 语种：中文; 页：EBYT201906011 页数：4 CN：06 ISSN：11-5175/R 分类号：41-44

摘要

目的探讨betatrophin在阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血浆中的水平及临床意义。方法选取2016年1月～2017年12月在我院睡眠中心行多道睡眠图(PSG)监测患者90例,分为非OSAHS组29例、轻中度OSAHS组31例和重度OSAHS组30例。采用酶联免疫吸附试验检测血清中betatrophin水平。用Logistics回归分析探讨OSAHS的影响因素。结果轻中度OSAHS组和重度OSAHS组患者年龄、体质量指数(BMI)、颈围、腰臀比(waist-to-hip ratio,WHR)、呼吸暂停低通气指数(AHI)、最低指脉氧饱和度(lowest SpO_2,LSpO_2)、氧减指数(oxygen desaturation index,ODI)、氧饱和度低于90%的时间占睡眠的百分比(the percent of time spent below90%oxygensaturation,Ts90%)、TG和betatrophin高于非OSAHS组,差异有统计学意义(P <0.05);重度OSAHS组患者年龄、BMI、颈围、WHR、AHI、LSpO_2、ODI、Ts90%、甘油三酯(triglycerides,TG)和betatrophin高于轻中度OSAHS组,差异有统计学意义(P <0.05)。剔除混杂因素的影响校正后,血清betatrophin水平与性别呈独立负相关,与BMI、WHR、ODI和血脂异常呈独立正相关(β=-0.342、0.438、0.639、0.185、0.336,P均<0.05);年龄、BMI、W HR和betat rophin是OSAHS患者评估的独立危险因素(OR=1.259、1.706、3.315、1.226,P均<0.05)。结论血清betatrophin是OSAHS患者评估的独立危险因素,可为预测OSAHS提供线索。
        OBJECTIVE To investigate the plasma level of betatrophin in patients with obstructive sleep apnea hypopnea syndrome(OSAHS) and its clinical significance. METHODS A total of 90 patients underwent polysomnograghy(PSG) in our hospital from January 2016 to December 2017 were selected and divided into three groups: non-OSAHS group(n=29), mild-moderate OSAHS group(n=31), and severe OSAHS group(n=30). Enzymelinked immunosorbent assay was used to detect the serum level of betatrophin. Logistic regression analysis was used to explore the inf luencing factors of OSAHS. RESULTS The age, BMI, neck circumference, WHR, AHI, LSpO2,ODI, Ts90%, TG and betatrophin in the mild-moderate OSAHS group and severe OSAHS group were higher than those in non-OSAHS group(P <0.05). The age, BMI, neck circumference, WHR, AHI, LSpO_2, ODI, Ts90%, TG and betatrophin in the severe OSAHS group were higher than those in mild-moderate OSAHS group(P <0.05). After correcting for the confounding factors, serum betatrophin level was negatively correlated with gender, and positively correlated with BMI, WHR, ODI and dyslipidemia(β=-0.342, 0.438, 0.639, 0.185, 0.336, P <0.05). The age,BMI, WHR and betatrophin were independent risk factors for OSAHS patients(OR=1.259, 1.706, 3.315, 1.226, P <0.05).CONCLUSION Serum betatrophin is an independent risk factor for OSAHS patients, which can be used as a predictor.

引文

[1]Yazgan S,Erboy F,Celik HU,et al.Peripapillary Choroidal Thickness and Retinal Nerve Fiber Layer in Untreated Patients with Obstructive Sleep Apnea-Hypopnea Syndrome:A CaseControl Study.Curr Eye Res,2017,42(11):1552-1560.
    [2]张志刚,何权瀛.2011-2015年中华医学会系列杂志发表的阻塞性睡眠呼吸暂停低通气综合征相关研究现状分析.中华结核和呼吸杂志,2017,40(1):75-76.
    [3]Singhal P,Joshi Y,Singh G,et al.Study of factors affecting compliance of continuous positive airway pressure(CPAP)in obstructive sleep apnea-hypopnea syndrome(OSAHS).Eur Respir J,2016,48(60):2362-2376.
    [4]李丽疆,李相英,苗小风,等.促代谢因子betatrophin与糖尿病的研究进展.基础医学与临床,2017,37(1):114-117.
    [5]杨敏,于菁,马小羽,等.初诊2型糖尿病患者不同尿白蛋白阶段血清betatrophin、脂联素及白细胞介素1β水平的相关性研究.中华内分泌代谢杂志,2017,33(2):116-119.
    [6]中华医学会呼吸病学分会睡眠呼吸障碍学组.阻塞性睡眠呼吸暂停低通气综合征诊治指南(2011年修订版).中华结核和呼吸杂志,2012,35(1):9-12.
    [7]顾晨鹃,李庆云,李敏,等.青年肥胖阻塞性睡眠呼吸暂停低通气综合征患者糖代谢异常的影响因素.中华医学杂志,2016,96(18):1405-1409.
    [8]刘师伟,李欣,王明明,等.Betatrophin与1型和2型糖尿病患者胰岛β细胞功能及其他代谢指标的相关性.中华临床营养杂志,2016,24(5):278-284.
    [9]Hu W,Shao X,Guo D,et al.Relationship of Serum Betatrophin with Nonalcoholic Fatty Liver in a Chinese Population.PLoSOne,2017,12(1):e0170758.
    [10]李丽疆,李相英,苗小风,等.促代谢因子betatrophin与糖尿病的研究进展.基础医学与临床,2017,37(1):114-117.
    [11]杨敏,于菁,马小羽,等.初诊2型糖尿病患者不同尿白蛋白阶段血清betatrophin、脂联素及白细胞介素1β水平的相关性研究.中华内分泌代谢杂志,2017,33(2):116-119.
    [12]Frühbeck G,Catalán V,Rodríguez A,et al.Normalization of adiponectin concentrations by leptin replacement in ob/ob mice is accompaniedby reductions in systemic oxidative stress and inflammation.Sci Rep,2017,7(1):2752.
    [13]杨成伟,王取南,陈可洋.瘦素改善2型糖尿病ob/ob小鼠糖和脂质代谢作用机制的探讨.中华疾病控制杂志,2016,20(9):940-944.
    [14]李睿琳,陈慧英,苏纪平.脑源性神经营养因子在OSAHS并发神经功能损害中的作用研究进展.山东医药,2016,56(32):107-109.
    [15]隋淼.Betatrophin研究进展.医学研究生学报,2018,31(3):318-322.
    [16]李庆学,张淑芳,马春莲,等.betatrophin与β细胞增殖.中国新药与临床杂志,2016,35(5):314-318.