彩色多普勒超声联合CT诊断结节性甲状腺肿合并甲状腺癌的临床价值
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摘要
目的探讨彩色多普勒超声联合CT检查对结节性甲状腺肿合并甲状腺癌的诊断价值。方法收集选择结节性甲状腺肿合并甲状腺癌患者124例,对彩色多普勒超声、CT检查进行对比。结果联合应用诊断效果显著优于彩色多普勒超声或CT检查(P<0.05)。彩色多普勒超声与CT检查无显著性差异(P>0.05)。联合应用检查结节性甲状腺肿并甲状腺癌具有较高的敏感性、特异性以及准确性,阳性预测值以及阴性预测值均较高,而假阳性率以及假阴性率均较低。结节性甲状腺肿并甲状腺癌的彩色多普勒超声主要表现为:结节形态不规则,边缘与周围组织不清楚,有毛刺征;结节有钙化病灶;以Ⅱ～Ⅲ级的血流为主;部分患者有颈部或锁骨淋巴结转移。CT表现主要为:结节形态不规则,密度不均,边界不清,结节内有钙化病灶;无包膜或包膜中断不完整;增强扫描可以形成"强化残圈征",病灶内部不均匀强化;部分患者有颈部或锁骨淋巴结转移。结论彩色多普勒联合CT检查能提高结节性甲状腺肿合并甲状腺癌的诊断准确性。
引文
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[10]吴莉莉,郑荣琴,陈军,等.结节性甲状腺肿合并甲状腺癌与单纯甲状腺癌超声表现比较[J].中国误诊学杂志,2009,9(25):6115-6116.
[2]Erdas E,Licheri S,Pisano G,et al.Basedow's disease associated with benign and malignant nodular disease of the thyroid:diagnosis and treatment[J].Chir Ital,2004,56(2):175-184.
[3]Zak T,Golenko A,B WR,et al.The bone mineral density and the markers of the osseous circle in children with non-toxic parenchymatous or nodular goiter long-time treated with L-thyroxine[J].Endokrynol Diabetol Chor Przemiany Materii Wieku Rozw,2005,11(1):13-17.
[4]Mereu P,Scala M,Schenone F,et al.Non-toxic nodular goiter:treatment and follow-up[J].Acta Otorhinolaryngol Ital,1995,15(4):301-304.
[5]王亚军,李春辉,李亚新,等.彩色多普勒超声诊断甲状腺微小癌的临床应用价值[J].河北医学,2016,22(3):487-489.
[6]O'Brien S,Golubovskaya VM,Conroy J,et al.FAK inhibition with small molecule inhibitor Y15 decreases viability,clonogenicity,and cell attachment in thyroid cancer cell lines and synergizes with targeted therapeutics[J].Oncotarget,2014,5(17):7945-7959.
[7]Das TK,Cagan RL.A Drosophila approach to thyroid cancer therapeutics[J].Drug Discov Today Technol,2013,10(1):65-71.
[8]卢丽萍,何小乔,邓英.结节性甲状腺肿合并甲状腺癌的超声诊断及其误诊分析[J].中国现代医生,2010,(20):74-75+77.
[9]许媛媛,裘浙林,陈秋燕,等.结节性甲状腺肿合并甲状腺癌的超声诊断临床分析[J].医学影像学杂志,2012,22(5):836-838.
[10]吴莉莉,郑荣琴,陈军,等.结节性甲状腺肿合并甲状腺癌与单纯甲状腺癌超声表现比较[J].中国误诊学杂志,2009,9(25):6115-6116.