加味五虎汤治疗痰热闭肺型小儿支原体肺炎
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摘要
目的分析加味五虎汤治疗痰热闭肺型小儿支原体肺炎的临床效果。方法选取90例痰热闭肺型小儿支原体肺炎,采取随机数字表法分为对照组与观察组,各45例。对照组给予阿奇霉素治干混悬剂治疗,观察组在对照组治疗基础上加用加味五虎汤治疗。对比2组临床疗效、症状消失时间及外周血T淋巴细胞亚群水平。结果观察组与对照组比较临床总显效率较高,差异具有统计学意义(P <0.05)。2组比较发热、咳嗽、喘息、肺部干湿啰音临床症状消失时间比较,差异具有统计学意义(P <0.05)。2组治疗后与治疗前比较CD4~+水平升高、CD8~+水平降低、CD4~+/CD8~+水平升高,观察组治疗后与对照组治疗后比较上述指标改善更加显著,差异具有统计学意义(P <0.05)。结论在常规西药治疗的基础上加用加味五虎汤治疗痰热闭肺型小儿支原体肺炎,能够明显缓解临床症状,改善免疫因子水平。
Objective To explore and analyze the clinical eff ect of Wuhu decoction on the treatment of phlegm fever. Methods 90 cases of phlegm heat closed type lung pediatric mycoplasma pneumoniawas divided into control group and observation group, 45 cases in each group. control group given azithromycin dry suspension agent treatment, observation group was treated with Wuhu decoction. The clinical efficacy, symptom disappearance time and T lymphocyte subsets in peripheral blood were compared. Results Compared with the control group, the total clinical efficiency was higher and the difference was statistically significant(P < 0.05). The clinical symptoms of fever, cough, wheezing, and lung bubble sound in the observation group were shorter than those in the control group, and the diff erence was statistically significant(P < 0.05). After treatment, CD4~+ level increased, CD8~+ level decreased, and D4~+/CD8~+ level increased after treatment in both groups. The improvement of above indexes in observation group was more significant than that in control group after treatment, and the diff erence was statistically significant(P < 0.05). Conclusion The treatment of mycoplasma pneumoniae in children with phlegm-heat blocking pulmonary type by adding modified Wuhu decoction on the basis of routine western medicine treatment can obviously promote the relief of clinical symptoms and improve the level of immune factors.
Objective To explore and analyze the clinical eff ect of Wuhu decoction on the treatment of phlegm fever. Methods 90 cases of phlegm heat closed type lung pediatric mycoplasma pneumoniawas divided into control group and observation group, 45 cases in each group. control group given azithromycin dry suspension agent treatment, observation group was treated with Wuhu decoction. The clinical efficacy, symptom disappearance time and T lymphocyte subsets in peripheral blood were compared. Results Compared with the control group, the total clinical efficiency was higher and the difference was statistically significant(P < 0.05). The clinical symptoms of fever, cough, wheezing, and lung bubble sound in the observation group were shorter than those in the control group, and the diff erence was statistically significant(P < 0.05). After treatment, CD4~+ level increased, CD8~+ level decreased, and D4~+/CD8~+ level increased after treatment in both groups. The improvement of above indexes in observation group was more significant than that in control group after treatment, and the diff erence was statistically significant(P < 0.05). Conclusion The treatment of mycoplasma pneumoniae in children with phlegm-heat blocking pulmonary type by adding modified Wuhu decoction on the basis of routine western medicine treatment can obviously promote the relief of clinical symptoms and improve the level of immune factors.
引文
[1]陈丽珠,陈杰奎.桑杏汤联合阿奇霉素治疗小儿支原体肺炎临床疗效观察[J].中药药理与临床, 2015, 31(4):216-218.
[2]席日升,刘海,张晓俞,等.中西医结合治疗痰热闭肺型小儿支原体肺炎46例[J].中国药业, 2015, 24(20):106-107.
[3]戴丽凤,陈淡璋.阿奇霉素与红霉素治疗儿童肺炎支原体肺炎的比较[J].中国药业, 2012, 21(19):109-110.
[4]刘运香,王彦彬,刘祥.痰热清联合阿奇霉素治疗肺炎支原体肺炎临床研究[J].中医学报, 2012, 27(8):1456-1457.
[5]吴秋英,吴娅.中医辨证分型与阿奇霉素联用治疗小儿肺炎支原体肺炎的临床研究[J].中华中医药学刊, 2016,34(3):754-757.
[6]杨帆,王静,张广彬. 93例小儿支原体肺炎临床分析[J].中国民康医学, 2012, 24(9):1099-1100.
[7]王利玲,杜琳麟,程申.阿奇霉素联合热毒宁治疗肺炎支原体感染患儿血清炎性因子的影响分析[J].中华医院感染学杂志, 2014, 24(4):863-865.
[8]窦蕾,张斌,费那尔,等.乌鲁木齐地区住院呼吸道感染患儿EB病毒感染的调查[J].临床儿科杂志, 2012, 30(8):757-760.
[9]唐涛.阿奇霉素联合红霉素治疗小儿支原体肺炎40例临床分析[J].当代医学, 2012, 18(1):690-691.
[10]王丽燕.单次与分次静脉用红霉素治疗支原体肺炎的临床观察[J].中国药物与临床, 2014, 14(4):491-492.
[11]洪玮.阿奇霉素联合中药治疗小儿肺炎支原体肺炎的疗效观察[J].临床合理用药, 2012, 5(10):69-70.
[12]谭志团.儿童肺炎支原体肺炎临床表现及发病机制研究[J].中国妇幼保健, 2013, 28(34):5647-5649.
[13]张晓娟,沈伊娜.小儿肺炎支原体肺炎发病机制的研究进展[J].安徽医学, 2016, 37(1):111-113.
[14]左志昌,张建设,徐秀,等.银翘组方联合阿奇霉素治疗小儿痰热闭肺型肺炎喘嗽的疗效观察[J].陕西中医,2014, 35(3):283-284.
[15]刘玲,姚宝珍.加味五虎汤联合阿奇霉素干混悬剂治疗痰热闭肺型小儿支原体肺炎临床研究[J].中医学报, 2017,32(3):20-21.
[16]丁峰.加味五虎汤联合背穴药物贴敷治疗痰热闭肺型小儿支原体肺炎疗效观察[J].黑龙江医药, 2017, 30(3):90-91.
[17]刘鉴.加味五虎汤对痰热闭肺型小儿支原体肺炎疗效及T淋巴细胞亚群、细胞因子的调节作用[J].陕西中医,2016, 37(10):123-124.
[18]王彦平,高貂艳,郝巧茸.加味五虎汤加减灌肠辅治痰热闭肺型小儿肺炎60例[J].陕西中医, 2017, 38(10):1360-1361.
[19]代如民,陈爽,张彦博.五虎汤合葶苈大枣泻肺汤加减治疗新生儿支原体肺炎痰热闭肺证临床研究[J].中医学报,2017, 32(3):20-21.
[20]杨洁,潘鸿,李静.五虎汤合葶苈大枣泄肺汤治疗肺炎喘嗽痰热闭肺证患儿的临床观察[J].中国社区医师, 2017,33(4):30-31.
[2]席日升,刘海,张晓俞,等.中西医结合治疗痰热闭肺型小儿支原体肺炎46例[J].中国药业, 2015, 24(20):106-107.
[3]戴丽凤,陈淡璋.阿奇霉素与红霉素治疗儿童肺炎支原体肺炎的比较[J].中国药业, 2012, 21(19):109-110.
[4]刘运香,王彦彬,刘祥.痰热清联合阿奇霉素治疗肺炎支原体肺炎临床研究[J].中医学报, 2012, 27(8):1456-1457.
[5]吴秋英,吴娅.中医辨证分型与阿奇霉素联用治疗小儿肺炎支原体肺炎的临床研究[J].中华中医药学刊, 2016,34(3):754-757.
[6]杨帆,王静,张广彬. 93例小儿支原体肺炎临床分析[J].中国民康医学, 2012, 24(9):1099-1100.
[7]王利玲,杜琳麟,程申.阿奇霉素联合热毒宁治疗肺炎支原体感染患儿血清炎性因子的影响分析[J].中华医院感染学杂志, 2014, 24(4):863-865.
[8]窦蕾,张斌,费那尔,等.乌鲁木齐地区住院呼吸道感染患儿EB病毒感染的调查[J].临床儿科杂志, 2012, 30(8):757-760.
[9]唐涛.阿奇霉素联合红霉素治疗小儿支原体肺炎40例临床分析[J].当代医学, 2012, 18(1):690-691.
[10]王丽燕.单次与分次静脉用红霉素治疗支原体肺炎的临床观察[J].中国药物与临床, 2014, 14(4):491-492.
[11]洪玮.阿奇霉素联合中药治疗小儿肺炎支原体肺炎的疗效观察[J].临床合理用药, 2012, 5(10):69-70.
[12]谭志团.儿童肺炎支原体肺炎临床表现及发病机制研究[J].中国妇幼保健, 2013, 28(34):5647-5649.
[13]张晓娟,沈伊娜.小儿肺炎支原体肺炎发病机制的研究进展[J].安徽医学, 2016, 37(1):111-113.
[14]左志昌,张建设,徐秀,等.银翘组方联合阿奇霉素治疗小儿痰热闭肺型肺炎喘嗽的疗效观察[J].陕西中医,2014, 35(3):283-284.
[15]刘玲,姚宝珍.加味五虎汤联合阿奇霉素干混悬剂治疗痰热闭肺型小儿支原体肺炎临床研究[J].中医学报, 2017,32(3):20-21.
[16]丁峰.加味五虎汤联合背穴药物贴敷治疗痰热闭肺型小儿支原体肺炎疗效观察[J].黑龙江医药, 2017, 30(3):90-91.
[17]刘鉴.加味五虎汤对痰热闭肺型小儿支原体肺炎疗效及T淋巴细胞亚群、细胞因子的调节作用[J].陕西中医,2016, 37(10):123-124.
[18]王彦平,高貂艳,郝巧茸.加味五虎汤加减灌肠辅治痰热闭肺型小儿肺炎60例[J].陕西中医, 2017, 38(10):1360-1361.
[19]代如民,陈爽,张彦博.五虎汤合葶苈大枣泻肺汤加减治疗新生儿支原体肺炎痰热闭肺证临床研究[J].中医学报,2017, 32(3):20-21.
[20]杨洁,潘鸿,李静.五虎汤合葶苈大枣泄肺汤治疗肺炎喘嗽痰热闭肺证患儿的临床观察[J].中国社区医师, 2017,33(4):30-31.