猪流感病毒的进化及其对人类的威胁
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摘要
猪流感病毒危害养猪业可持续发展的同时,也对人类健康构成了严重威胁。长期以来,猪被认为是人流感病毒和禽流感病毒的中间宿主并发挥着基因"混合器"的作用,促使猪流感病毒不断进化变异和发生基因重组。历史上的几次流感大流行,尤其是2009年首发于墨西哥的H1N1大流感,与猪流感病毒密切相关。文章从猪流感病毒的基因组进化、猪群中的流行状况及其对人类的潜在威胁等方面进行了简要综述,以期为大流感预警的相关研究提供参考。
Swine influenza virus not only damages the sustainable development of pig industry,but also poses a severe threat to human health.Pigs have been long considered the intermediate host of human influenza virus and avian influenza virus to function as the genetic " mixing vessel",thereby facilitating the continued evolution and variation plus reassortment of swine influenza virus.Historically,the past influenza pandemics,especially the pandemic H1 N1 influenza that firstly emerged in Mexico in 2009,have close genetic relationship with swine influenza virus.In this review,the genomic evolution,the prevalence status in pig population and the potential threat to human beings of swine influenza virus will be briefly discussed,aiming to provide suggestions for the studies relevant to flu pandemic alert.
Swine influenza virus not only damages the sustainable development of pig industry,but also poses a severe threat to human health.Pigs have been long considered the intermediate host of human influenza virus and avian influenza virus to function as the genetic " mixing vessel",thereby facilitating the continued evolution and variation plus reassortment of swine influenza virus.Historically,the past influenza pandemics,especially the pandemic H1 N1 influenza that firstly emerged in Mexico in 2009,have close genetic relationship with swine influenza virus.In this review,the genomic evolution,the prevalence status in pig population and the potential threat to human beings of swine influenza virus will be briefly discussed,aiming to provide suggestions for the studies relevant to flu pandemic alert.
引文
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[15]LU L,LYCETT S J,LEIGH BROWN A J.Reassortment patterns of avian influenza virus internal segments among different subtypes[J].BMC Evolutionary Biology,2014,14(1):1-15.
[16]RESA-INFANTE P,JORBA N,COLOMA R,et al.The influenza virus RNA synthesis machine:advances in its structure and function[J].RNA Biology,2011,8(2):207-215.
[17]URBANIAK K,MARKOWSKA-DANIEL I.In vivo reassortment of influenza viruses[J].Acta Biochimica Polonica,2014,61(3):427-431.
[18]TSCHERNE D M,GARCIA-SASTRE A.Virulence determinants of pandemic influenza viruses[J].Journal of Clinical Investigation,2011,121(1):6-13.
[19]BROWN I H.The epidemiology and evolution of influenza viruses in pigs[J].Veterinary Microbiology,2000,74(1-2):29-46.
[20]ZELL R,SCHOLTISSEK C,LUDWIG S.Genetics,evolution,and the zoonotic capacity of european swine influenza viruses[M]//Swine Influenza.Springer Berlin Heidelberg,2012:29-55.
[21]KUNDIN W D.Hong Kong A-2influenza virus infection among swine during a human epidemic in Taiwan[J].Nature,1970,228(5274):857-857.
[22]KOMADINA N,MCVERNON J,HALL R,et al.A historical perspective of influenza A(H1N2)virus[J].Emerging Infectious Diseases,2014,20(1):6-12.
[23]KARASIN A I,OLSEN C W,ANDERSON G A.Genetic characterization of an H1N2influenza virus isolated from a pig in Indiana[J].Journal of Clinical Microbiology,2000,38(6):2 453-2 456.
[24]WEBSTER R G,BEAN W J,GORMAN O T,et al.Evolution and ecology of influenza A viruses[J].Microbiological Reviews,1992,56(1):152-179.
[25]QI X,PANG B,LU C P.Genetic characterization of H1N1swine influenza A viruses isolated in eastern China[J].Virus Genes,2009,39(2):193-199.
[26]BI Y,FU G,CHEN J,et al.Novel swine influenza virus reassortants in pigs,China[J].Emerging Infectious Diseases,2010,16(7):1 162-1 164.
[27]VIJAYKRISHNA D,SMITH G J,PYBUS O G,et al.Long-term evolution and transmission dynamics of swine influenza A virus[J].Nature,2011,473(7348):519-522.
[28]ZHAO G,FAN Q,ZHONG L,et al.Isolation and phylogenetic analysis of pandemic H1N1/09influenza virus from swine in Jiangsu province of China[J].Research in Veterinary Science,2012,93(1):125-132.
[29]ZHU H,ZHOU B,FAN X,et al.Novel reassortment of Eurasian avian-like and pandemic/2009influenza viruses in swine:infectious potential for humans[J].Journal of Virology,2011,85(20):10 432-10 439.
[30]SMITH T F,BURGERT E O JR,DOWDLE W R,et al.Isolation of swine influenza virus from autopsy lung tissue of man[J].The New England Journal of Medicine,1976,294(13):708-710.
[31]CHUVAKOVA Z K,ROVNOVA Z I,ISAEVA E I,et al.3cases of isolating the influenza A virus with human hemagglutin in Hsw1in 1983in Alma-Ala[J].Vopr Virusol,1985,30(5):530-536.
[32]GREGORY V,LIM W,CAMERON K,et al.Infection of a child in Hong Kong by an influenza A H3N2virus closely related to viruses circulating in European pigs[J].Journal of General Virology,2001,82(Pt 6):1 397-1 406.
[33]VAN REETH K,NICOLL A.A human case of swine influenza virus infection in Europe--implications for human health and research[J].Euro Surveill,2009,14(7):2-4.
[34]GARTEN R J,DAVIS C T,RUSSELL C A,et al.Antigenic and genetic characteristics of swine-origin 2009A(H1N1)influenza viruses circulating in humans[J].Science,2009,325(5937):197-201.
[35]KONG W,WANG F,DONG B,et al.Novel reassortant influenza viruses between pandemic(H1N1)2009and other influenza viruses pose a risk to public health[J].Microbial Pathogenesis,2015,89(5937):62-72.
[36]QI X,CUI L,JIAO Y,et al.Antigenic and genetic characterization of a European avian-like H1N1swine influenza virus from a boy in China in 2011[J].Archives of Virology,2013,158(1):39-53.
[37]LOPEZ-ROBLES G,MONTALVO-CORRAL M,CAIREJUVERA G,et al.Seroprevalence and risk factors for swine influenza zoonotic transmission in swine workers from Northwestern Mexico[J].Transboundary&Emerging Diseases,2012,59(2):183-188.
[38]MA M,ANDERSON B D,TAO W,et al.Serological Evidence and risk factors for swine influenza infections among Chinese swine workers in Guangdong province[J].Plos One,2015,10(5):e0128479.
[2]祁贤,陆承平.猪流感病毒进化方式及其流行特点[J].微生物学报,2009,49(9):1 138-1 145.
[3]TROMBETTA C,PICCIRELLA S,PERINI D,et al.Emerging influenza strains in the last two decades:A threat of a new pandemic?[J].Vaccines,2015,3(1):172-185.
[4]孟慧芝,孙涛,岳志芹,等.一株H1N1亚型猪流感病毒全基因克隆及遗传特性分析[J].动物医学进展,2015,36(6):48-53.
[5]余华.猪流感病毒分子生物学研究进展[J].动物医学进展,2010,31(S1):208-212.
[6]朱闻斐,舒跃龙.人感染猪流感病毒概述[J].病毒学报,2013,29(5):559-565.
[7]SHOPE R E.Swine influenza:Ⅲ.Filtration experiments and etionlogy[J].Journal of Experimental Medicine,1931,54(3):373-385.
[8]KONG W,YE J,GUAN S,et al.Epidemic status of Swine influenza virus in china[J].Indian Journal of Microbiology,2014,54(1):3-11.
[9]杨帅,朱闻斐,舒跃龙.猪流感病毒概述[J].病毒学报,2013,29(3):330-336.
[10]GLASER L,STEVENS J,ZAMARIN D,et al.A single amino acid substitution in 1918influenza virus hemagglutinin changes receptor binding specificity[J].Journal of Virology,2005,79(17):11 533-11 536.
[11]TUMPEY T M,MAINES T R,HOEVEN N V,et al.A twoamino acid change in the hemagglutinin of the 1918influenza virus abolishes transmission[J].Science,2007,315(5812):655-659.
[12]STEEL J,LOWEN A C,MUBAREKA S,et al.Transmission of influenza virus in a mammalian host is increased by PB2amino acids 627K or 627E/701N[J].Plos Pathogens,2009,5(1):e1000252.
[13]陶洁,殷秀辰,李星,等.猪流感病毒分离株A/swine/Shanghai/3/2014(H1N1)分子特性研究[J].中国兽医学报,2016,36(3):389-394.
[14]SCHNELL J R,CHOU J J.Structure and mechanism of the M2proton channel of influenza a virus[J].Nature,2008,451(7178):591-595.
[15]LU L,LYCETT S J,LEIGH BROWN A J.Reassortment patterns of avian influenza virus internal segments among different subtypes[J].BMC Evolutionary Biology,2014,14(1):1-15.
[16]RESA-INFANTE P,JORBA N,COLOMA R,et al.The influenza virus RNA synthesis machine:advances in its structure and function[J].RNA Biology,2011,8(2):207-215.
[17]URBANIAK K,MARKOWSKA-DANIEL I.In vivo reassortment of influenza viruses[J].Acta Biochimica Polonica,2014,61(3):427-431.
[18]TSCHERNE D M,GARCIA-SASTRE A.Virulence determinants of pandemic influenza viruses[J].Journal of Clinical Investigation,2011,121(1):6-13.
[19]BROWN I H.The epidemiology and evolution of influenza viruses in pigs[J].Veterinary Microbiology,2000,74(1-2):29-46.
[20]ZELL R,SCHOLTISSEK C,LUDWIG S.Genetics,evolution,and the zoonotic capacity of european swine influenza viruses[M]//Swine Influenza.Springer Berlin Heidelberg,2012:29-55.
[21]KUNDIN W D.Hong Kong A-2influenza virus infection among swine during a human epidemic in Taiwan[J].Nature,1970,228(5274):857-857.
[22]KOMADINA N,MCVERNON J,HALL R,et al.A historical perspective of influenza A(H1N2)virus[J].Emerging Infectious Diseases,2014,20(1):6-12.
[23]KARASIN A I,OLSEN C W,ANDERSON G A.Genetic characterization of an H1N2influenza virus isolated from a pig in Indiana[J].Journal of Clinical Microbiology,2000,38(6):2 453-2 456.
[24]WEBSTER R G,BEAN W J,GORMAN O T,et al.Evolution and ecology of influenza A viruses[J].Microbiological Reviews,1992,56(1):152-179.
[25]QI X,PANG B,LU C P.Genetic characterization of H1N1swine influenza A viruses isolated in eastern China[J].Virus Genes,2009,39(2):193-199.
[26]BI Y,FU G,CHEN J,et al.Novel swine influenza virus reassortants in pigs,China[J].Emerging Infectious Diseases,2010,16(7):1 162-1 164.
[27]VIJAYKRISHNA D,SMITH G J,PYBUS O G,et al.Long-term evolution and transmission dynamics of swine influenza A virus[J].Nature,2011,473(7348):519-522.
[28]ZHAO G,FAN Q,ZHONG L,et al.Isolation and phylogenetic analysis of pandemic H1N1/09influenza virus from swine in Jiangsu province of China[J].Research in Veterinary Science,2012,93(1):125-132.
[29]ZHU H,ZHOU B,FAN X,et al.Novel reassortment of Eurasian avian-like and pandemic/2009influenza viruses in swine:infectious potential for humans[J].Journal of Virology,2011,85(20):10 432-10 439.
[30]SMITH T F,BURGERT E O JR,DOWDLE W R,et al.Isolation of swine influenza virus from autopsy lung tissue of man[J].The New England Journal of Medicine,1976,294(13):708-710.
[31]CHUVAKOVA Z K,ROVNOVA Z I,ISAEVA E I,et al.3cases of isolating the influenza A virus with human hemagglutin in Hsw1in 1983in Alma-Ala[J].Vopr Virusol,1985,30(5):530-536.
[32]GREGORY V,LIM W,CAMERON K,et al.Infection of a child in Hong Kong by an influenza A H3N2virus closely related to viruses circulating in European pigs[J].Journal of General Virology,2001,82(Pt 6):1 397-1 406.
[33]VAN REETH K,NICOLL A.A human case of swine influenza virus infection in Europe--implications for human health and research[J].Euro Surveill,2009,14(7):2-4.
[34]GARTEN R J,DAVIS C T,RUSSELL C A,et al.Antigenic and genetic characteristics of swine-origin 2009A(H1N1)influenza viruses circulating in humans[J].Science,2009,325(5937):197-201.
[35]KONG W,WANG F,DONG B,et al.Novel reassortant influenza viruses between pandemic(H1N1)2009and other influenza viruses pose a risk to public health[J].Microbial Pathogenesis,2015,89(5937):62-72.
[36]QI X,CUI L,JIAO Y,et al.Antigenic and genetic characterization of a European avian-like H1N1swine influenza virus from a boy in China in 2011[J].Archives of Virology,2013,158(1):39-53.
[37]LOPEZ-ROBLES G,MONTALVO-CORRAL M,CAIREJUVERA G,et al.Seroprevalence and risk factors for swine influenza zoonotic transmission in swine workers from Northwestern Mexico[J].Transboundary&Emerging Diseases,2012,59(2):183-188.
[38]MA M,ANDERSON B D,TAO W,et al.Serological Evidence and risk factors for swine influenza infections among Chinese swine workers in Guangdong province[J].Plos One,2015,10(5):e0128479.
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