有机磷酸酯暴露水平与毒性效应的研究进展
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摘要
有机磷酸酯(Organophosphates esters,OPEs)作为一种新型的阻燃剂被广泛使用,替代了原有的溴代阻燃剂。目前已有研究表明OPEs普遍存在于环境中并具有潜在的毒性,所以受到了广泛的关注。因此本文综述了OPEs在环境基质中各个介质的暴露水平以及OPEs对水生生物、哺乳动物等生物体的神经毒性、生殖毒性和细胞毒性的研究。最后对OPEs的进一步研究以及存在的问题进行了分析和展望,以期促进中国的OPEs的生态环境和人体健康风险研究。
Organophosphates esters(OPEs) are widely used as a new type of flame retardant to replace the original brominated flame retardants. Previous research showed that OPEs were widespread in the environment and have potential toxicity,so it has attracted lots of attention. Therefore,this article reviewed the exposure level of OPEs in various media in environmental matrix and research on neurotoxicity,reproductive toxicity and cytotoxicity of OPEs to various organisms including aquatic organism and mammal. At last,the paper discussed the perspectives for future studies in order to promote the ecological environment and human health risk of OPEs in China.
Organophosphates esters(OPEs) are widely used as a new type of flame retardant to replace the original brominated flame retardants. Previous research showed that OPEs were widespread in the environment and have potential toxicity,so it has attracted lots of attention. Therefore,this article reviewed the exposure level of OPEs in various media in environmental matrix and research on neurotoxicity,reproductive toxicity and cytotoxicity of OPEs to various organisms including aquatic organism and mammal. At last,the paper discussed the perspectives for future studies in order to promote the ecological environment and human health risk of OPEs in China.
引文
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[4]何明靖,杨婷,杨志豪,等.有机磷酸酯在三峡库区土壤中污染特征[J].环境科学,2017,38(12):5256-5261.
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[10]赖晓芳,冯岸红,幸苑娜,等.固相萃取-气相色谱/质谱联用法测定儿童手推车中3种有机磷酸酯阻燃剂[J].色谱,2015,33(11):1186-1191.
[11]杨扬.有机磷酸酯(OPEs)对赤子爱胜蚓的毒性效应及机制研究[D].南京:南京大学,2018.
[12]景江,夏林军,吴菊珍,等.0,0-二甲基-(2,2,2-三氯-1-羟基乙基)磷酸酯对4种藻类生长的影响[J].生态毒理学报,2017,12(2):94-101.
[13]陈寒嫣.常用有机磷酸酯阻燃剂对斑马鱼肝脏毒性研究[D].南京:南京大学,2017.
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[15]Liu X,Ji K,Choi K.Endocrine disruption potentials of organophosphate flame retardants and related mechanisms in H295Rand MVLN cell lines and in zebrafish[J].Aquatic Toxicology,2012,114-115(3):173-181.
[2]王晓伟,刘景富,阴永光.有机磷酸酯阻燃剂污染现状与研究进展[J].化学进展,2010,22(10):1983-1992.
[3]吴迪,印红玲,李世平,等.成都市锦江表层水和沉积物中有机磷酸酯的污染特征[J].环境科学,2019(3):1-11.
[4]何明靖,杨婷,杨志豪,等.有机磷酸酯在三峡库区土壤中污染特征[J].环境科学,2017,38(12):5256-5261.
[6]Kurt-Karakus P,Alegria H,Birgul A,et al.Organophosphate ester(OPEs)flame retardants and plasticizers in air and soil from a highly industrialized city in Turkey[J].Science of the Total Environment,2017,625:555.
[5]Yadav I C,Devi N L,Li J,et al.Organophosphate ester flame retardants in Nepalese soil:Spatial distribution,source apportionment and air-soil exchange assessment[J].Chemosphere,2017,190:114-123.
[6]刘琴,印红玲,李蝶,等.室内灰尘中有机磷酸酯的分布及其健康风险[J].中国环境科学,2017,37(8):2831-2839.
[7]Sundkvist A M,Olofsson U,Haglund P.Orgaophosphous Flame Retardants and Plasticizers in Marine and Fresh Water Biota and in Human Milk[J].Journal of Environmental Monitoring,2010,12(4):943.
[8]Ding J,Xu Z,Huang W,et al.Organophosphate ester flame retardants and plasticizers in human placenta in Eastern China[J].Science of the Total Environment,2016,554-555:211-217.
[9]Ma Y,Jin J,Li P,et al.Organophosphate ester flame retardant concentrations and distributions in serum from inhabitants of Shandong,China,and changes between 2011 and 2015[J].Environmental Toxicology&Chemistry,2016,36(2).
[10]赖晓芳,冯岸红,幸苑娜,等.固相萃取-气相色谱/质谱联用法测定儿童手推车中3种有机磷酸酯阻燃剂[J].色谱,2015,33(11):1186-1191.
[11]杨扬.有机磷酸酯(OPEs)对赤子爱胜蚓的毒性效应及机制研究[D].南京:南京大学,2018.
[12]景江,夏林军,吴菊珍,等.0,0-二甲基-(2,2,2-三氯-1-羟基乙基)磷酸酯对4种藻类生长的影响[J].生态毒理学报,2017,12(2):94-101.
[13]陈寒嫣.常用有机磷酸酯阻燃剂对斑马鱼肝脏毒性研究[D].南京:南京大学,2017.
[14]Cao L Y,Ren X M,Li C H,et al.Organophosphate Esters Bind to and Inhibit Estrogen-Related Receptorγin Cells[J].Environmental Science&Technology Letters,2018,5(2).
[15]Liu X,Ji K,Choi K.Endocrine disruption potentials of organophosphate flame retardants and related mechanisms in H295Rand MVLN cell lines and in zebrafish[J].Aquatic Toxicology,2012,114-115(3):173-181.