呼吸道病毒靶点的研究进展
摘要
<正>病毒进入机体的途径对其增殖、传播及其逃逸机体的防卫机制均有强烈的影响。人们通过呼吸道接受的病毒感染要比其他途径都多,一方面是因为呼吸是人类生存所必需,现代社会人们日渐亲密的交际方式,使呼吸道感染愈加难以避免;另一方面,呼吸道对病毒而言是一个相对容易感染的途径,众多病毒可克服屏障进入机体,使人患病。呼吸道病毒种类很多,流感病毒、呼吸道合胞病毒、麻疹病毒是三类典型的代表,了解这3种病毒的靶点研究进展,对认识呼吸道
引文
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[2]李艳华.抗禽流感病毒中药及盐酸金刚烷胺诱导M2基因变异的研究[D].哈尔滨:东北农业大学,2003.
[3]谢元超.以神经氨酸酶为靶点的抗流感病毒先导化合物的发现[D].济南:山东大学,2014.
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[7]吕慧敏.以碱性聚合酶2(PB2)为靶点的抗流感病毒候选药物结合自由能计算及结合[D].上海:上海交通大学,2011.
[8]Ortigoza MB,Dibben O,Maamary J,et al.A novel small molecule inhibitor of influenza A viruses that targets polymerase function and indirectly induces interferon[J].PLo S Pathog,2012,8(4):e1002668.
[9]Hsu JT,Yeh JY,Lin TJ,et al.Identification of BPR3P0128 as an inhibitor of cap-snatching activities of influenza virus[J].Antimicrob Agents Chemother,2012,56(2):647-657.
[10]罗芬,马卫列,张志珍.甲型流感病毒RNA聚合酶——抗病毒药物靶点[J].中国生物化学与分子生物学报,2014,30(5):434-440.
[11]张强,展鹏,刘新泳.RNA聚合酶——抗流感病毒的新靶点[J].生命的化学,2012,32(1):12-16.
[12]Engel DA.The influenza virus NS1 protein as a therapeutic target[J].Antiviral Res,2013,99(3):409-416.
[13]Patnaik S,Basu D,Dehdashti S,et al.Discovery of Small Molecule Influenza Virus NS1 Antagonist[DB/OL].Probe Reports from the NIH Molecular Libraries Program[Internet].Bethesda(MD):National Center for Biotechnology Information(US);2010-2012 Apr 13[updated 2013 Sep 03].
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[15]Sakaguchi A,Hirayama E,Hiraki A,et al.Nuclear export of influenza viral ribonucleo protein is temperature-dependently inhibited by dissociation of viral matrix protein[J].Virology,2003,306(2):244-253.
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[18]Sudo K,Konno K,Watanabe W,et al.Mechanism of selective inhibition of respiratory syncytial virus by a benzodithiin compound(RD3-0028)[J].Microbiol Immunol,2001,45(7):531-537.
[19]Kimura K,Moir S,Tomita K,et al.Antiviral activity of NMSO3against respiratory syncytial virus infection in vitroand in vivo[J].Antiviral Res,2000,47(1):41-51.
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[21]Wyde PR,Chetty SN,Timmerman P,et al.Short duration aerosols of JNJ 2408068(R170591)administered prophylactically or therapeutically protect cotton rats from experimental respiratory syncytial virus infection[J].Antiviral Res,2003,60(3):221-231.
[22]张梅,王小波,付远辉,等.抗人呼吸道合胞病毒融合糖蛋白单克隆抗体的制备及体外鉴定[J].中国生物工程杂志,2012,32(2):63-68.
[23]周庆,罗智,赵东赤,等.抗呼吸道合胞病毒感染的新药物作用靶点的筛选[J].湖北中医药大学学报,2013,15(16):20-24.
[24]周娟.广谱脱氧核酶抗不同免疫功能小鼠呼吸道合胞病毒感染的研究[D].重庆:重庆医科大学,2006.
[25]崔玉霞.小发卡结构状RNA联合脱氧核酶抗呼吸道合胞病毒实验研究[D].重庆:重庆医科大学,2006.
[26]逯光文,高福,严景华.麻疹病毒受体与病毒侵入[J].生物工程学报,2013,29(1):1-9.
[27]史俊岩,王美莲,刘兵,等.靶向Rab9 GTPase基因shRNA体外抑制麻疹病毒Edmonston株复制的研究[J].中国病原生物学杂志,2011,6(3):164-167.
[28]Fontaan JM,Bankamp B,Bellini WJ,et al.Regulation of interferon signaling by the C and V proteins from attenuated and wild-type strains of measles virus[J].Virology,2008,374(1):71-81.
[29]冯德杰,刘晨鸣,赵雅静,等.麻疹病毒F基因测序及其进化关系的初步分析[J].微生物学免疫学进展,2010,38(2):18-23.
[2]李艳华.抗禽流感病毒中药及盐酸金刚烷胺诱导M2基因变异的研究[D].哈尔滨:东北农业大学,2003.
[3]谢元超.以神经氨酸酶为靶点的抗流感病毒先导化合物的发现[D].济南:山东大学,2014.
[4]郭莹莹.A型流感病毒NS1抑制剂的计算机辅助设计[D].北京:中国农业科学院,2010.
[5]Cianci C,Gerritz SW,Deminie C,et al.Influenza nucleoprotein:promising target for antiviral chemotherapy[J].Antivir Chem Chemother,2013,23(3):77-91.
[6]张瑞涛,姜世勃,刘叔文.靶向血凝素的流感病毒进入抑制剂研究进展[J].中国药学杂志,2010,45(16):1208-1212.
[7]吕慧敏.以碱性聚合酶2(PB2)为靶点的抗流感病毒候选药物结合自由能计算及结合[D].上海:上海交通大学,2011.
[8]Ortigoza MB,Dibben O,Maamary J,et al.A novel small molecule inhibitor of influenza A viruses that targets polymerase function and indirectly induces interferon[J].PLo S Pathog,2012,8(4):e1002668.
[9]Hsu JT,Yeh JY,Lin TJ,et al.Identification of BPR3P0128 as an inhibitor of cap-snatching activities of influenza virus[J].Antimicrob Agents Chemother,2012,56(2):647-657.
[10]罗芬,马卫列,张志珍.甲型流感病毒RNA聚合酶——抗病毒药物靶点[J].中国生物化学与分子生物学报,2014,30(5):434-440.
[11]张强,展鹏,刘新泳.RNA聚合酶——抗流感病毒的新靶点[J].生命的化学,2012,32(1):12-16.
[12]Engel DA.The influenza virus NS1 protein as a therapeutic target[J].Antiviral Res,2013,99(3):409-416.
[13]Patnaik S,Basu D,Dehdashti S,et al.Discovery of Small Molecule Influenza Virus NS1 Antagonist[DB/OL].Probe Reports from the NIH Molecular Libraries Program[Internet].Bethesda(MD):National Center for Biotechnology Information(US);2010-2012 Apr 13[updated 2013 Sep 03].
[14]张强,赵庆杰,熊瑞生,等.抗流感病毒药物研究进展[J].药学学报,2010,45(3):289-299.
[15]Sakaguchi A,Hirayama E,Hiraki A,et al.Nuclear export of influenza viral ribonucleo protein is temperature-dependently inhibited by dissociation of viral matrix protein[J].Virology,2003,306(2):244-253.
[16]Sun Z,Pan Y,Jiang S,et al.Respiratory syncytial virus entry inhibitors targeting the F protein[J].Viruses,2013,5(1):211-225.
[17]夏秋玲.呼吸道合胞病毒分离培养及其F蛋白基因变异分析[D].重庆:重庆医科大学,2013.
[18]Sudo K,Konno K,Watanabe W,et al.Mechanism of selective inhibition of respiratory syncytial virus by a benzodithiin compound(RD3-0028)[J].Microbiol Immunol,2001,45(7):531-537.
[19]Kimura K,Moir S,Tomita K,et al.Antiviral activity of NMSO3against respiratory syncytial virus infection in vitroand in vivo[J].Antiviral Res,2000,47(1):41-51.
[20]Huntlay CC,Weiss WJ,Gazumyan A,et al.RFI-641,a potent respiratory syncytial virus inhibitor[J].Antimicrob Agents Chemother,2002,46(3):841-847.
[21]Wyde PR,Chetty SN,Timmerman P,et al.Short duration aerosols of JNJ 2408068(R170591)administered prophylactically or therapeutically protect cotton rats from experimental respiratory syncytial virus infection[J].Antiviral Res,2003,60(3):221-231.
[22]张梅,王小波,付远辉,等.抗人呼吸道合胞病毒融合糖蛋白单克隆抗体的制备及体外鉴定[J].中国生物工程杂志,2012,32(2):63-68.
[23]周庆,罗智,赵东赤,等.抗呼吸道合胞病毒感染的新药物作用靶点的筛选[J].湖北中医药大学学报,2013,15(16):20-24.
[24]周娟.广谱脱氧核酶抗不同免疫功能小鼠呼吸道合胞病毒感染的研究[D].重庆:重庆医科大学,2006.
[25]崔玉霞.小发卡结构状RNA联合脱氧核酶抗呼吸道合胞病毒实验研究[D].重庆:重庆医科大学,2006.
[26]逯光文,高福,严景华.麻疹病毒受体与病毒侵入[J].生物工程学报,2013,29(1):1-9.
[27]史俊岩,王美莲,刘兵,等.靶向Rab9 GTPase基因shRNA体外抑制麻疹病毒Edmonston株复制的研究[J].中国病原生物学杂志,2011,6(3):164-167.
[28]Fontaan JM,Bankamp B,Bellini WJ,et al.Regulation of interferon signaling by the C and V proteins from attenuated and wild-type strains of measles virus[J].Virology,2008,374(1):71-81.
[29]冯德杰,刘晨鸣,赵雅静,等.麻疹病毒F基因测序及其进化关系的初步分析[J].微生物学免疫学进展,2010,38(2):18-23.