口腔黏膜扁平苔藓患者心理状况分析
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摘要
目的:分析口腔扁平苔藓疾病(OLP)患者的心理状况。方法:采用焦虑自评量表(SAS),抑郁自评量表(SDS),大五人格量表(NEO)和世界卫生组织生存质量测定量表简表(WHOQOL-BREF),对口腔黏膜扁平苔藓患者(n=100)和正常人群(n=100)进行问卷调查,并检测血清中促肾上腺激素(ACTH)和皮质醇(CORT)水平;分析口腔扁平苔藓与心理疾病、应激、人格特征和生活质量之间的关系。结果:病例组和对照组在一般资料(性别和年龄)中无统计学差异(P>0. 05),病例组和对照组在SAS评分、SDS评分、NEO评分、WHOQOL-BREF评分和血清中ACTH、CORT水平存在显著性差异(P <0. 05);二分类Logistic回归分析显示焦虑、抑郁、人格品质和生活质量可能是OLP患病的影响因素。结论:OLP疾病的发生发展可能与心理状况、抑郁、应激、焦虑等有关联。
Objective: To investigate the pschological status of the patients with oral lichen planus disease( OLP). Methods: 100 patients with OLP and 100 healthy controls were included. The self-rating anxiety scale( SAS),self-rating depression scale( SDS),neuroticism extraversion openness( NEO) and WHOQOL-BREF were used to analyze the life quality and pschology of the subjects.Andrenocor-cicotropin( ACTH) and cortisol( CORT) in serum were measured. The relationship between OLP and mental illness,stress,personality traits and life quality was analyzed. Results: There were no significant differences of gender and age between the case group and the control group( P > 0. 05). There were significant differences of the SAS score,SDS score,NEO score,WHOQOLBREF score and the level of ACTH and CORT( P < 0. 05) in serum between the 2 groups. Logistic regression analysis showed that anxiety,depression,personality and life quality were the influencing factors of OLP prevalence. Conclusion: The development of OLP may be related to psychological status,depression,stress,anxiety and so on.
Objective: To investigate the pschological status of the patients with oral lichen planus disease( OLP). Methods: 100 patients with OLP and 100 healthy controls were included. The self-rating anxiety scale( SAS),self-rating depression scale( SDS),neuroticism extraversion openness( NEO) and WHOQOL-BREF were used to analyze the life quality and pschology of the subjects.Andrenocor-cicotropin( ACTH) and cortisol( CORT) in serum were measured. The relationship between OLP and mental illness,stress,personality traits and life quality was analyzed. Results: There were no significant differences of gender and age between the case group and the control group( P > 0. 05). There were significant differences of the SAS score,SDS score,NEO score,WHOQOLBREF score and the level of ACTH and CORT( P < 0. 05) in serum between the 2 groups. Logistic regression analysis showed that anxiety,depression,personality and life quality were the influencing factors of OLP prevalence. Conclusion: The development of OLP may be related to psychological status,depression,stress,anxiety and so on.
引文
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[19]侯大为,柳志文.口腔扁平苔藓患者负性生活事件、人格特征与血清皮质醇的相关性研究[J].实用口腔医学杂志,2010,26(6):796-798.
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[2]吉辉芳.疏肝健脾治疗糜烂性口腔扁平苔藓26例[J].光明中医,2011,26(6):1167.
[3]江晨艳,姚辉,唐国瑶.口腔扁平苔藓相关致病基因研究进展[J].临床口腔医学杂志,2011,27(5):313-315.
[4]谷晓平,李虹.他克莫司软膏治疗口腔扁平苔藓的短期疗效评价[J].中国医药指南,2014,12(27):250-253.
[5]童建明,杨正春,龙赟,彭志聪,何政全.综合医院中医科住院患者焦虑抑郁状况调查[J].临床心身疾病杂志,2007,13(6):490-492.
[6]顾华芳.精神科护理人员焦虑抑郁状况与社会支持的调查分析[J].上海护理,2006,6(4):17-19.
[7]毛晋平,何炎芬.大学生大五人格与学习适应性的关系研究[J].中国临床心理学杂志,2008,16(2):200-201.
[8]方积乾,郝元涛,李彩霞.世界卫生组织生活质量量表中文版的信度与效度[J].中国心理卫生杂志,1999,13(4):203-205.
[9]胡利杰,杨阳.增生平治疗口腔扁平苔癣的疗效观察[J].中国卫生产业,2011,8:66.
[10]刘远桥.120例口腔扁平苔藓病的相关危险因素分析[J].中国医疗美容,2015,5(1):139-140.
[11]萧智利,吴树洪,向学熔,等.160例口腔扁平苔藓病的相关危险因素分析[J].重庆医学,2010,39(10):1241-1242.
[12]Suresh PK.Membrane-bound versus soluble major histocompatibility complex Class I-related chain A and major histocompatibility complex Class I-related chain B differential expression:Mechanisms of tumor eradication versus evasion and current drug development strategies[J].J Cancer Res Ther,2016,12(4):1224-1233.
[13]曹烈虎,王思成,张前进,等.WHOQOL-BREF量表评价艾灸治疗膝骨性关节炎的临床疗效研究[J].中国骨伤,2009,22(11):813-815.
[14]陆敏,彭军,尤春景,等.WHOQOL-BREF在脑卒中偏瘫患者中的应用[J].中华物理医学与康复杂志,2004,26(4):22-24.
[15]王婷.口腔扁平苔藓发病相关风险因素的Logistic回归分析[J].中国煤炭工业医学杂志,2014,17(3):384-386.
[16]王英杰,张克进,孟宪敏.扁平苔藓患者的社会心理因素及部分免疫反应的变化[J].中国麻风皮肤病杂志,2013,29(8):513-515.
[17]孙振晓,于相芬,徐静.口腔扁平苔癣与心理社会因素的关系[J].中国心理卫生杂志,2007,21(9):643-645.
[18]费慧芝,胡小娅,邱红梅,等.丙戊酸钠对慢性不可预见性温和刺激致抑郁大鼠行为学及下丘脑-垂体-肾上腺皮质轴功能的影响[J].中国生物制品学杂志,2016,29(8):829-833.
[19]侯大为,柳志文.口腔扁平苔藓患者负性生活事件、人格特征与血清皮质醇的相关性研究[J].实用口腔医学杂志,2010,26(6):796-798.
[20]Burkhart NW,Burker EJ,Burkes EJ,et al.Assessing the characteristics of patients with oral lichen planus[J].J Am Dent Assoc,1996,127(5):648,651-652,655-656.