蒽醌类天然化合物及肿瘤治疗研究进展
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摘要
醌类化合物是一类天然存在的分子内含有不饱和环二酮结构的有机化合物,分为苯醌、萘醌、菲醌、蒽醌四种主要结构类型,其中蒽醌类化合物在自然界中分布广泛,具有抗菌抗病毒、抗肿瘤、抗氧化抗衰老、抗炎抗骨质疏松、利尿、止血等药物活性。对蒽醌天然化合物的种类、化学结构、抗肿瘤活性进行综述。
Quinones are natural organic compounds with unsaturated cyclodione structure. Quinones are classified into four main structural types: quinone, naphthraquinone, phenanthraquinone and anthraquinone. Among them, anthraquinones are widely distributed in nature, with the drug activities of antibacterial and antiviral, anti-tumor, anti-oxidation and anti-aging,anti-inflammatory and anti-osteoporosis, diuretic, hemostatic and so on. The types, chemical structures,antitumor activities of anthraquinone natural compounds are reviewed in this paper.
Quinones are natural organic compounds with unsaturated cyclodione structure. Quinones are classified into four main structural types: quinone, naphthraquinone, phenanthraquinone and anthraquinone. Among them, anthraquinones are widely distributed in nature, with the drug activities of antibacterial and antiviral, anti-tumor, anti-oxidation and anti-aging,anti-inflammatory and anti-osteoporosis, diuretic, hemostatic and so on. The types, chemical structures,antitumor activities of anthraquinone natural compounds are reviewed in this paper.
引文
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[20]张扬武,罗伟生,郑景辉,等.大黄蒽醌化合物体外抗SIV的蛋白质组学研究[J].中华中医药学刊,2017,35(11):2842-2851.
[21]彭政,田炜,蓝富,等.黄根提取物抗乙型肝炎病毒活性的初步研究[J].广西医科大学学报,2017,34(6):820-822.
[2]陈毅,王海丽,薛露,等.茜草的研究进展[J].中草药,2017,48(13):2771-2779.
[3]林楠,王荫荫,吴杰.蒽酮及其衍生物生物活性研究进展[J].贵州医药,2018(2):170-172.
[4]郝静,冯世秀,邱声祥,等.黄根中的蒽醌苷成分(英文)[J].Chinese Journal of Natural Medicines,2011(1):42-45.
[5]何学鹏,陈鹏,杨凯.去甲氧柔红霉素联合阿糖胞苷治疗急性髓系白血病的临床疗效[J].实用癌症杂志,2016,31(1):160-162.
[6]郭青.去甲氧柔红霉素联合硼替佐米对急性髓细胞白血病细胞免疫原性凋亡的影响[D].安徽医科大学,2016.
[7]Faderl S,Wo'Brien W.Fludarabine,cyclophosphamide,mitoxantrone plus rituximab(FCM-R)in frontline CLL<70 years[J].Leukemia Research,2010,34(3):284-288.
[8]李静.大黄素衍生物对慢性髓细胞白血病细胞及高致瘤K562细胞裸鼠异种移植瘤的体内外作用及机制研究[D].福建医科大学,2012.
[9]Stieglitz E,Dinh T,Phelps A S,et al.ABVD without radiation for newly diagnosed pediatric and young adult patients with hodgkin lymphoma:a single center retrospective analysis of 28 consecutive patients[J].Journal of Pediatric Hematology/oncology,2018,40(4):290.
[10]吴辉菁,于丁,杨业勤,等.ABVD方案成功解救难治性弥漫大B细胞淋巴瘤1例报道[J].肿瘤防治研究,2016,43(11):1008-1010.
[11]张广迎,刘接班.RCHOP治疗弥漫大B细胞性淋巴瘤32例临床观察[J].实用癌症杂志,2017,32(3):517-519.
[12]Salamoon M,Bachour M,Hussein T,et al.Treatment of peripheral T cell lymphoma with an intensive protocol ACEP(adriamycin,cyclophosphamide,etoposide and prednisolone)and ifosfamide showing an important response and overall survival rates[J].Medical Oncology,2013,30(2):1-5.
[13]李云祥,梁引库,高飞雄,等.中药治疗乳腺癌疾病研究进展[J].中国实验方剂学杂志,2019(3):211-219.
[14]Abu N,Zamberi N R,Yeap S K,et al.Subchronic toxicity,immunoregulation and anti-breast tumor effect of Nordamnacantal,an anthraquinone extracted from the stems of Morinda citrifolia L[J].Bmc Complementary&Alternative Medicine,2018,18(1):31.
[15]Song X,Zhou X,Qin Y,et al.Emodin inhibits epithelial-mesenchymal transition and metastasis of triple negative breast cancer via antagonism of CC-chemokine ligand 5 secreted from adipocytes[J].International Journal of Molecular Medicine,2018.
[16]王晓梅,赵卫星,韩晓东,等.索骨丹提取物抗氧化及对乳腺癌细胞的抑制作用[J].氨基酸和生物资源,2015,37(3):33-35.
[17]郝强.靶向于雌激素受体的长循环米托蒽醌脂质体及其抗肿瘤研究[D].吉林大学,2017.
[18]Rc D S O,Corrêa R J,Teixeira R S,et al.Silica nanoparticles doped with anthraquinone for lung cancer phototherapy[J].Journal of Photochemistry&Photobiology B Biology,2016,165:1-9.
[19]Wang G,Zhang D,Yang S,et al.Co-administration of genistein with doxorubicin-loaded polypeptide nanoparticles weakens the metastasis of malignant prostate cancer by amplifying oxidative damage[J].Biomaterials Science,2018,6(4).
[20]张扬武,罗伟生,郑景辉,等.大黄蒽醌化合物体外抗SIV的蛋白质组学研究[J].中华中医药学刊,2017,35(11):2842-2851.
[21]彭政,田炜,蓝富,等.黄根提取物抗乙型肝炎病毒活性的初步研究[J].广西医科大学学报,2017,34(6):820-822.