柴胡加龙骨牡蛎汤治疗广泛性焦虑症临床观察
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摘要
[目的]探讨柴胡加龙骨牡蛎汤治疗广泛性焦虑症的临床效果。[方法]选择2017年1月至2018年6月衢州市中医医院脑病科门诊就诊的186例广泛性焦虑症患者作为观察对象,将患者随机分为研究组和对照组。请康复科医师会诊后,对两组患者进行心理放松训练,研究组患者给予柴胡加龙骨牡蛎颗粒剂口服,对照组予安慰剂口服,其颜色、味道、服法、剂量与柴胡加龙骨牡蛎颗粒剂完全相同。采用汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)、焦虑自评量表(self-rating anxiety scale,SAS)、焦虑因子评分(symptom check list-90,SCL-90)评估两组患者治疗前后的焦虑状态改善程度及中医症状积分。[结果]两组患者治疗前HAMA、SAS、SCL-90焦虑因子的评分差异无统计学意义(P>0.05);治疗后两组患者焦虑状态均明显缓解,研究组的3种评分值均低于对照组,差异有统计学意义(P<0.05)。研究组总有效率高于对照组,差异有统计学意义(P<0.05)。研究组改善焦虑症心悸、烦躁症状效果显著。[结论]柴胡加龙骨牡蛎汤治疗焦虑症能够改善患者焦虑状态,临床效果较好,值得推广应用。
[Objective]To explore the clinical effect of Bupleurum plus dragon bone oyster soup in the treatment of generalized anxiety disorder. [Methods]One hundred and eighty-six patients with generalized anxiety disorder admitted to our department from January 2017 to June 2018 were selected and randomly divided into study group and control group. After the consultation, patients in the two groups were given psychological relaxation training. Study group was given oral administratin of Bupleurum plus dragon bone oyster granules, and control group was given a placebo, whose color, taste, usage and dosage were the same as the granules. Hamilton anxiety scale(HAMA), self-rating anxiety scale(SAS) and symptom check list-90(SCL-90) were used to evaluate the improvement of anxiety state of the two groups before and after treatment. [Results]The difference of scores of the HAMA, SAS,SCL-90 and TCM symptom of the two groups were not statistically significant before treatment(P >0.05), and the anxiety state of the two groups was significantly relieved and the three scores of study group were all lower than control group, and the difference was statistically significant(P<0.05). The total effective rate of study group was higher than control group, and the difference was statistically significant(P<0.05). The palpitation and dysphoria symptoms were significantly improved in study group. [Conclusion] Bupleurum plus dragon bone oyster soup has good clinical effect on anxiety disorders, and is worthy of popularization and application.
[Objective]To explore the clinical effect of Bupleurum plus dragon bone oyster soup in the treatment of generalized anxiety disorder. [Methods]One hundred and eighty-six patients with generalized anxiety disorder admitted to our department from January 2017 to June 2018 were selected and randomly divided into study group and control group. After the consultation, patients in the two groups were given psychological relaxation training. Study group was given oral administratin of Bupleurum plus dragon bone oyster granules, and control group was given a placebo, whose color, taste, usage and dosage were the same as the granules. Hamilton anxiety scale(HAMA), self-rating anxiety scale(SAS) and symptom check list-90(SCL-90) were used to evaluate the improvement of anxiety state of the two groups before and after treatment. [Results]The difference of scores of the HAMA, SAS,SCL-90 and TCM symptom of the two groups were not statistically significant before treatment(P >0.05), and the anxiety state of the two groups was significantly relieved and the three scores of study group were all lower than control group, and the difference was statistically significant(P<0.05). The total effective rate of study group was higher than control group, and the difference was statistically significant(P<0.05). The palpitation and dysphoria symptoms were significantly improved in study group. [Conclusion] Bupleurum plus dragon bone oyster soup has good clinical effect on anxiety disorders, and is worthy of popularization and application.
引文
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[12]陈国统,何杨伟,汪碧云.柴胡龙骨牡蛎汤加减结合抗焦虑抑郁药物对躯体化焦虑、抑郁状态的疗效及机制分析[J].中华中医药学刊,2017,35(3):758-760.
[2]刘扬,赵丽娜,武萌萌,等.柴胡加龙骨牡蛎汤临床研究概况[J].中医药临床杂志,2016,28(5):740-742.
[3]冯璐,张琦,郝乔,等.放松训练结合中医认知疗法治疗焦虑症的疗效[J].辽宁中医杂志,2017,44(9):1868-1869.
[4]中华医学会精神科学会.中国精神障碍分类与诊断标准[M].3版.济南:山东科学技术出版社,2001:105-107.
[5]国家中医药管理局.中医病证诊断疗效标准[M].北京:中国医药科技出版社,2017:33.
[6]郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:216.
[7]陈琪,杨德爽,李诗梦,等.柴胡加龙骨牡蛎汤研究进展[J].医学综述,2016,22(17):3441-3444.
[8]刘洋,李华南,张玮.非药物治疗广泛性焦虑症的研究进展[J].时珍国医国药,2016,27(11):2722-2724.
[9]赵晶,全亚萍,陈园桃.广泛性焦虑症中医药研究进展[J].辽宁中医药大学学报,2015,17(4):210-212.
[10]王振亮.张仲景理法方药临床应用[M].北京:中国中医药出版社,2018:118.
[11]黄煌.经方使用手册[M].北京:中国中医药出版社,2015:8-9.
[12]陈国统,何杨伟,汪碧云.柴胡龙骨牡蛎汤加减结合抗焦虑抑郁药物对躯体化焦虑、抑郁状态的疗效及机制分析[J].中华中医药学刊,2017,35(3):758-760.