细胞分裂周期蛋白14生物学功能的研究进展
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摘要
细胞分裂周期蛋白14 (Cdc14)属于高度保守的丝、苏氨酸双特异性磷酸酶家族,能够下调周期素依赖性激酶(CDK)的活性,是重要的细胞周期调节蛋白,在真核生物细胞中广泛表达。Cdc14在不同的真核细胞中生物学功能相差甚远。在出芽酵母细胞中,Cdc14通过逆转CDK的活性,进而调节出芽酵母细胞有丝分裂退出网络;在裂殖酵母细胞中,Cdc14的同源物多聚腺苷酸因子Clp1对于裂殖酵母细胞有丝分裂的退出无明显影响;在人类细胞中,Cdc14的同源物人类Cdc14A (hCdc14A)可使CDK失活,控制有丝分裂的时间。基于国内外对Cdc14的研究成果,现针对Cdc14在出芽酵母细胞、非洲裂殖酵母细胞、秀丽隐杆线虫细胞、非洲爪蟾细胞、鸟类细胞、小鼠卵母细胞和人类细胞7种不同真核生物细胞中的分型、定位及其生物学功能等进行综述,为Cdc14的研究提供参考。
引文
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[14]DE W P,MONTANI F,VISINTIN R.Protein phosphatases take the mitotic stage[J].Curr Opin Cell Biol,2009,21(6):806-815.
[15]STEGMEIER F,VISINTIN R,AMON A.Separase,polo kinase,the kinetochore protein slk19,and spo12function in a network that controls Cdc14 localization during early anaphase[J].Cell,2002,108(2):207-220.
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[17]CUEILLE N,SALIMOVA E,ESTEBAN V,et al.Flp1,a fission yeast orthologue of the s.cerevisiae CDC14gene,is not required for cyclin degradation or rum1p stabilisation at the end of mitosis[J].J Cell Sci,2001,114(Pt 14):2649-2664.
[18]TRAUTMANN S,WOLFE B A,JORGENSEN P,et al.Fission yeast Clp1p phosphatase regulates G2/M transition and coordination of cytokinesis with cell cycle progression[J].Curr Biol,2001,11(12):931-940.
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[21]GRUNEBERG U,GLOTZER M,GARTNER A,et al.The CeCDC-14 phosphatase is required for cytokinesis in the Caenorhabditis elegans embryo[J].J Cell Biol,2002,158(5):901-914.
[22]SAITO R M,PERREAULT A,PEACH B,et al.The CDC-14phosphatase controls developmental cell-cycle arrest in C.elegans[J].Nat Cell Biol,2004,6(8):777-783.
[23]KHMELINSKII A,LAWRENCE C,ROOSTALU J,et al.Cdc14-regulated midzone assembly controls anaphase B[J].J Cell Biol,2007,177(6):981-993.
[24]MOCCIARO A,SCHIEBEL E.Cdc14:a highly conserved family of phosphatases with non-conserved functions?[J].J Cell Sci,2010,123(Pt 17):2867-2876.
[25]KRASINSKA L,DE BETTIGNIES G,FISHER D,et al.Regulation of multiple cell cycle events by Cdc14homologues in vertebrates[J].Exp Cell Res,2007,313(6):1225-1239.
[26]MAILAND N,LUKAS C,KAISER B K,et al.Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation[J].Nat Cell Biol,2002,4(4):317-322.
[27]SCHINDLER K,SCHULTZ R M.The CDC14A phosphatase regulates oocyte maturation in mouse[J].Cell Cycle,2009,8(7):1090-1098.
[28]SCHINDLER K,SCHULTZ R M.CDC14B acts through FZR1(CDH1)to prevent meiotic maturation of mouse oocytes[J].Biol Reprod,2009,80(4):795-803.
[29]LI L,LJUNGMAN M,DIXON J E.The human Cdc14phosphatases interact with and dephosphorylate the tumor suppressor protein p53[J].J Biol Chem,2000,275(4):2410-2414.
[30]SACRISTN M P,OVEJERO S,BUENO A.Human Cdc14Abecomes a cell cycle gene in controlling Cdk1activity at the G2/M transition[J].Cell Cycle,2011,10(3):387-391.
[31]WATANABE N,ARAI H,NISHIHARA Y,et al.M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1by SCFβ-TrCP[J].Proc Natl Acad Sci U S A,2004,101(13):4419-4424.
[32]TUMURBAATAR I,CIZMECIOGLU O,HOFFMANN I,et al.Human Cdc14Bpromotes progression through mitosis by dephosphorylating Cdc25 and regulating CDK1/Cyclin Bactivity[J].PLoS One,2011,6(2):e14711.
[33]VZQUEZ-NOVELLE M D,ESTEBAN V,BUENO A,et al.Functional homology among human and fission yeast Cdc14phosphatases[J].J Biol Chem,2005,280(32):29144-29150.
[34]WU S M,WANG W D,KONG X D,et al.Dynamic regulation of the PR-Set7histone methyltransferase is required for normal cell cycle progression[J].Genes Dev,2010,24(22):2531-2542.
[2]DORE M,HUNT T.From Cdc2to CDK1:when did the cell cycle kinase join its cyclin partner?[J].J Cell Sci,2002,115(Pt12):2461-2464.
[3]李瑞林,孟峻.细胞分裂周期蛋白14B在肿瘤中的研究进展[J].临床检验杂志,2018,36(8):632-633.
[4]苏日古嘎,孟峻.细胞分裂周期蛋白Cdc14A功能的研究进展[J].吉林大学学报:医学版,2018,44(5):1105-1108.
[5]GRAY C H,GOOD V M,TONKS N K,et al.The structure of the cell cycle protein Cdc14reveals a proline-directed protein phosphatase[J].EMBO J,2003,22(14):3524-3535.
[6]BERDOUGO E,NACHURY M V,JACKSON P K,et al.The nucleolar phosphatase Cdc14B is dispensable for chromosome segregation and mitotic exit in human cells[J].Cell Cycle,2008,7(9):1184-1190.
[7]CHO H P,LIU Y E,GOMEZ M,et al.The dual-specificity phosphatase CDC14Bbundles and stabilizes microtubules[J].Mol Cell Biol,2005,25(11):4541-4551.
[8]MOCCIARO A,BERDOUGO E,ZENG K,et al.Vertebrate cells genetically deficient for Cdc14A or Cdc14Bretain DNAdamage checkpoint proficiency but are impaired in DNArepair[J].J Cell Biol,2010,189(4):631-639.
[9]ROSSO L,MARQUES AC,WEIER M,et al.Birth and rapid subcellular adaptation of a hominoid-specific CDC14protein[J].PLoS Biol,2008,6(6):e140.
[10]CHEN C T,FEOKTISTOVA A,CHEN J S,et al.The SINkinase Sid2regulates cytoplasmic retention of the S.pombe Cdc14-like phosphatase Clp1[J].Curr Biol,2008,18(20):1594-1599.
[11]JASPERSEN S L,CHARLES J F,MORGAN D O.Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14[J].Curr Biol,1999,9(5):227-236.
[12]STEGMEIER F,AMON A.Closing mitosis:the functions of the Cdc14 phosphatase and its regulation[J].Annu Rev Genet,2004,38(1):203-232.
[13]QUERALT E,UHLMANN F.Cdk-counteracting phosphatases unlock mitotic exit[J].Curr Opin Cell Biol,2008,20(6):661-668.
[14]DE W P,MONTANI F,VISINTIN R.Protein phosphatases take the mitotic stage[J].Curr Opin Cell Biol,2009,21(6):806-815.
[15]STEGMEIER F,VISINTIN R,AMON A.Separase,polo kinase,the kinetochore protein slk19,and spo12function in a network that controls Cdc14 localization during early anaphase[J].Cell,2002,108(2):207-220.
[16]JENSEN S,JOHNSTON L H.Complexity of mitotic exit[J].Cell Cycle,2002,1(5):300-303.
[17]CUEILLE N,SALIMOVA E,ESTEBAN V,et al.Flp1,a fission yeast orthologue of the s.cerevisiae CDC14gene,is not required for cyclin degradation or rum1p stabilisation at the end of mitosis[J].J Cell Sci,2001,114(Pt 14):2649-2664.
[18]TRAUTMANN S,WOLFE B A,JORGENSEN P,et al.Fission yeast Clp1p phosphatase regulates G2/M transition and coordination of cytokinesis with cell cycle progression[J].Curr Biol,2001,11(12):931-940.
[19]GRUNEBERG U,NEEF R,HONDA R,et al.Relocation of aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2[J].J Cell Biol,2004,166(2):167-172.
[20]ESTEBAN V,BLANCO M,CUEILLE N,et al.A role for the Cdc14-family phosphatase Flp1p at the end of the cell cycle in controlling the rapid degradation of the mitotic inducer Cdc25p in fission yeast[J].J Cell Sci,2004,117(Pt 12):2461-2468.
[21]GRUNEBERG U,GLOTZER M,GARTNER A,et al.The CeCDC-14 phosphatase is required for cytokinesis in the Caenorhabditis elegans embryo[J].J Cell Biol,2002,158(5):901-914.
[22]SAITO R M,PERREAULT A,PEACH B,et al.The CDC-14phosphatase controls developmental cell-cycle arrest in C.elegans[J].Nat Cell Biol,2004,6(8):777-783.
[23]KHMELINSKII A,LAWRENCE C,ROOSTALU J,et al.Cdc14-regulated midzone assembly controls anaphase B[J].J Cell Biol,2007,177(6):981-993.
[24]MOCCIARO A,SCHIEBEL E.Cdc14:a highly conserved family of phosphatases with non-conserved functions?[J].J Cell Sci,2010,123(Pt 17):2867-2876.
[25]KRASINSKA L,DE BETTIGNIES G,FISHER D,et al.Regulation of multiple cell cycle events by Cdc14homologues in vertebrates[J].Exp Cell Res,2007,313(6):1225-1239.
[26]MAILAND N,LUKAS C,KAISER B K,et al.Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation[J].Nat Cell Biol,2002,4(4):317-322.
[27]SCHINDLER K,SCHULTZ R M.The CDC14A phosphatase regulates oocyte maturation in mouse[J].Cell Cycle,2009,8(7):1090-1098.
[28]SCHINDLER K,SCHULTZ R M.CDC14B acts through FZR1(CDH1)to prevent meiotic maturation of mouse oocytes[J].Biol Reprod,2009,80(4):795-803.
[29]LI L,LJUNGMAN M,DIXON J E.The human Cdc14phosphatases interact with and dephosphorylate the tumor suppressor protein p53[J].J Biol Chem,2000,275(4):2410-2414.
[30]SACRISTN M P,OVEJERO S,BUENO A.Human Cdc14Abecomes a cell cycle gene in controlling Cdk1activity at the G2/M transition[J].Cell Cycle,2011,10(3):387-391.
[31]WATANABE N,ARAI H,NISHIHARA Y,et al.M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1by SCFβ-TrCP[J].Proc Natl Acad Sci U S A,2004,101(13):4419-4424.
[32]TUMURBAATAR I,CIZMECIOGLU O,HOFFMANN I,et al.Human Cdc14Bpromotes progression through mitosis by dephosphorylating Cdc25 and regulating CDK1/Cyclin Bactivity[J].PLoS One,2011,6(2):e14711.
[33]VZQUEZ-NOVELLE M D,ESTEBAN V,BUENO A,et al.Functional homology among human and fission yeast Cdc14phosphatases[J].J Biol Chem,2005,280(32):29144-29150.
[34]WU S M,WANG W D,KONG X D,et al.Dynamic regulation of the PR-Set7histone methyltransferase is required for normal cell cycle progression[J].Genes Dev,2010,24(22):2531-2542.