溶剂解吸-气相色谱法测定工作场所空气中N-甲基-2-吡咯烷酮

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英文篇名：Determination of N-methyl-2-pyrrolidone in workplace air by solvent desorption-gas chromatography 作者：蒙瑞波 ; 戎伟丰 ; 胡嘉雯 ; 何嘉恒 ; 颜子丹 ; 佘媛媛 ; 吴邦华 英文作者：MENG Ruibo;RONG Weifeng;HU Jiawen;HE Jiaheng;YAN Zidan;SHE Yuanyuan;WU Banghua;Guangdong Province Hospital for Occupational Disease Prevention and Treatment,Guangdong Province Key Laboratory of Occupational Disease Prevention and Treatment; 关键词：工作场所 ; 空气 ; N-甲基-2-吡咯烷酮 ; 溶剂解吸 ; 气相色谱 英文关键词：Workplace;;Air;;N-Methyl-2-pyrrolidone;;Solvent desorption;;Gas chromatography 中文刊名：XYYX 英文刊名：China Occupational Medicine 机构：广东省职业病防治院广东省职业病防治重点实验室;广东省食品药品职业技术学校;中山大学公共卫生学院; 出版日期：2019-04-15 出版单位：中国职业医学 年：2019 期：v.46 基金：国家科技支撑计划项目(2014BAI12B01);; 广东省职业病防治重点实验室(2017B030314152) 语种：中文; 页：XYYX201902025 页数：4 CN：02 ISSN：44-1484/R 分类号：99-102

摘要

目的建立工作场所空气中N-甲基-2-吡咯烷酮(NMP)的溶剂解吸气相色谱测定方法。方法工作场所空气中NMP用活性炭管采集,经甲醇︰二氯甲烷(5∶95,V/V)解吸后,毛细管色谱柱分离,火焰离子化检测器测定。结果 NMP质量浓度在0.51～4 108.00 mg/L时线性关系良好,相关系数为0.999 9,检出限为0.08 mg/L(以3倍标准差计算)。方法平均解吸效率为101.68%～103.44%,批间、批内相对标准偏差分别为1.94%～3.97%、0.97%～2.26%。样品在室温下可保存14 d。结论本方法适用于工作场所空气中NMP的采样与检测。
        Objective To establish a method for determination of N-methyl-2-pyrrolidone(NMP) in workplace air by solvent desorption-gas chromatography. Methods NMP in the workplace air was collected with activated carbon tube and desorbed with methanol ∶dichloromethane(5 ∶95, V/V). After desorption, it was separated by capillary column separation, and detected by flame ionization detector. Results The good linear concentration of NMP was 0.51-4 108.00 mg/L. The correlation coefficient was 0.999 9. The detection limit was 0.08 mg/L(calculated by 3 times of standard deviation). The average desorption efficiency was 101.68%-103.44%. The within-run and between-run relative standard deviations were 1.94%-3.97% and 0.97%-2.26%, respectively. The sample could be stored at room temperature for at least 14 days. Conclusion The developed method is suitable for the determination of NMP in workplace air.

引文

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