血液酒精的近红外光谱法检测预放大电路设计
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摘要
基于近红外(near-infrared,NIR)光谱,提出一种血液酒精的检测方法,并设计一种低噪声、低漂移、高精度的前置预放大电路,该电路用于准确检测血液中酒精的体积分数。在本设计电路中的电流电压转化部分,选择使用2种电路对比的方法,通过Multisim电路仿真软件模拟来比较电路的漂移和误差,同时利用Matlab进行数据处理;预放大电路部分利用高共模抑制比的AD620设计了差分放大电路,来提高电路的共模抑制比(common mode rejection ratio,CMRR)。结果表明,使用对称补偿型低温漂电流电压变换电路,能够很好的抑制漂移降低误差,与常用的OP07电流电压转换电路相比,可降低误差约2%,可降低漂移约97%,为微弱信号的处理提供了依据。
A blood alcohol detection method was investigated based on NIR(near-infrared) spectroscopy.And a low-noise,low-drift and high-precision preamplifier was designed to detect the blood alcohol volume fraction accurately.In the current-voltage conversion section,the simulation of drift and error of two kinds of circuits were carried out by Multisim software.AD620 was selected in the preamplifier part which could improve the CMRR(common mode rejection ratio) of circuits.The results of simulation showed that the current-voltage conversion circuit of symmetrical compensational low-temperature drift can suppressed the drift and reduced error better.Compared with the OP07 current-voltage conversion circuit,the error could be reduced by 2%,while the draft could be reduced by 97%,which could support weak signal analyzing.
A blood alcohol detection method was investigated based on NIR(near-infrared) spectroscopy.And a low-noise,low-drift and high-precision preamplifier was designed to detect the blood alcohol volume fraction accurately.In the current-voltage conversion section,the simulation of drift and error of two kinds of circuits were carried out by Multisim software.AD620 was selected in the preamplifier part which could improve the CMRR(common mode rejection ratio) of circuits.The results of simulation showed that the current-voltage conversion circuit of symmetrical compensational low-temperature drift can suppressed the drift and reduced error better.Compared with the OP07 current-voltage conversion circuit,the error could be reduced by 2%,while the draft could be reduced by 97%,which could support weak signal analyzing.
引文
[1]邓进,李坤,罗开俭,等.贵州省2002年度道路交通事故调查[J].中华创伤杂志,2004,20(10):620-621.DENG Jin,LI Kun,LUO Kaijian,et al.The traffic accident investigation of Guizhou province in 2002[J].Chinese Journal of Trauma,2004,20(10):620-621.
[2]陈丽,朱瑞祥,云超.基于单片机的防酒后驾驶控制系统设计[J].传感器微系统,2009,28(2):94-95.CHEN Li,ZHU Ruixiang,YUN Chao.Design of antidrunk-driving control system based on MCU[J].Transducer and Micro-system Technologies,2009,28(2):94-95.
[3]BARBOZA F D,POPPI R J.Determination of alcohol content in beverages using short-wave near-infrared spectroscopy and temperature correction by transfer calibration procedures[J].Analytical and Bioanalytical Chemistry,2003,377(4):695-701.
[4]LIU Fei,HE Yong,WANG Li.Methods for the prediction of sugar content of rice wine using visible-near infrared spectroscopy[J].Acta Optica Sinica,2007,27(11):2054-2058.
[5]CHEN Bin,WANG Hao,LIN Song,et al.Analysis ofnear infrared spectroscopy of beer alcohol content by correlation coefficients and genetic algorithms[J].Transactions of the CSAE,2005,21(7):99-102.
[6]肖君.基于近红外三波长血糖检测系统的研制[D].武汉:华中科技大学,2006:35-40.XIAO Jun.A blood glucose detecting system based on three wavelengths in near-infared region[D].Wuhan:The Huazhong University of Science and Technology,2006:35-40.
[7]余辉.基于浮动基准法的无创血糖检测实验应用研究[J].光谱学与光谱分析,2012,32(3):771-772.YU Hui.Study on the experimental application of floating-reference method to noninvasive blood glucose sensing[J].Spectroscopy and Spectral Analysis,2012,32(3):771-772.
[8]MARUO K,TSURUGI M,CHIN J,et al.Noninvasive blood glucose assay using a newly developed near-infrared spectroscop[J].IEEE Journal of Selected Topics In Quantum Electronics,2003,9(2):322-329.
[9]张虹,孙卫新,金洁.脉搏血氧饱和度监测系统设计中干扰信号的处理方法[J].国外医学:生物医学工程分册,2000,23(2):90-95.ZHANG Hong,SUN Weixin,JIN Jie.Methods of noises elimination in the design of the pulse oximetry system[J].Foreign Medical Sciences:Biomedical Engineering Fascicle,2000,23(2):90-95.
[10]PRINGLE J,UYSTEPRUYST C,ART T,et al.Continuous and non-invasive study of brain oxygenation in the calf by near infrared spectroscopy[J].Research in Veterinary Science,1998,65:239-224.
[11]滕铁超,丁海曙,龚庆成,等.近红外光谱监测体外循环手术中脑组织氧合状况的研究[J].光谱学与光谱分析,2006,26(5):828-831.TENG Tiechao,DING Haishu,GONG Qingcheng,et al.Monitoring cerebral oxygenation using near infrared spectroscopy during cardiopulmonary bypass surgery[J].Spectroscopy and Spectral Analysis,2006,26(5):828-831.
[12]LI Z Y,ZHANG M,WANG Y,et al.Wavelet analysis of cerebral oxygenation signal measured by near infrared spectroscopy in subjects with cerebral infarction[J].Microvascular research,2010,80(1):142-147.
[13]LI Z Y,ZHANG M,WANG Y,et al.Wavelet analysis of sacral tissue oxygenation oscillations by near-infrared spectroscopy in persons with spinal cord injury[J].Microvascular research,2011,81(1):81-87.
[14]陈国强.汽车驾驶员血液酒精含量的近红外光谱法无损检测[D].济南:山东大学,2012.CHEN Guoqiang.Noninvasive analysis of blood alcohol in drivers based on near-infrared spectroscopy[D].Jinan:Shandong University,2012.
[15]罗斯特.人体血液中酒精浓度近红外光谱法无损检测及关键技术[D].济南:山东大学,2013.LUO Site.Noninvasive testing of blood alcohol concentration of body based on near-infrared spectroscopy and its key technology[D].Jinan:Shandong University,2013.
[16]罗斯特,卢丽倩,周伟伟,等.Monte-Carlo仿真酒精特征波长光子在皮肤中的传输规律及光纤探头[J].山东大学学报:理学版,2013,48(1):46-50.LUO Site,LU Liqian,ZHOU Weiwei,et al.MonteCaro simulation of photons transmission at alcohol wavelength in skin tissue and design of fiber optic probe[J].Journal of Shandong University:Natural Science,2013,48(1):46-50.
[17]徐可欣,高峰,赵会娟.生物医学光子学[M].北京:科学出版社,2007.
[18]童诗白,华成英.模拟电子技术基础[M].北京:高等教育出版社,2009:207-208.
[19]曹茂永,王霞,孙农亮.仪用放大器AD620及其应用[J].电测与仪表,2000,37(10):50-51.CAO Maoyong,WANG Xia,SUN Nongliang.Instrumentation amplifier AD620 and its application[J].Electrical Measurement&Instrumentation,2000,37(10):50-51.
[20]王炎.近红外无创血液成分测量——动态光谱检测理论及信号提取方法研究[D].天津:天津大学,2006.WANG Yan.Study on the detect theories and signal acquisition for dynamic spectrum[D].Tianjin:Tianjin University,2006.
[2]陈丽,朱瑞祥,云超.基于单片机的防酒后驾驶控制系统设计[J].传感器微系统,2009,28(2):94-95.CHEN Li,ZHU Ruixiang,YUN Chao.Design of antidrunk-driving control system based on MCU[J].Transducer and Micro-system Technologies,2009,28(2):94-95.
[3]BARBOZA F D,POPPI R J.Determination of alcohol content in beverages using short-wave near-infrared spectroscopy and temperature correction by transfer calibration procedures[J].Analytical and Bioanalytical Chemistry,2003,377(4):695-701.
[4]LIU Fei,HE Yong,WANG Li.Methods for the prediction of sugar content of rice wine using visible-near infrared spectroscopy[J].Acta Optica Sinica,2007,27(11):2054-2058.
[5]CHEN Bin,WANG Hao,LIN Song,et al.Analysis ofnear infrared spectroscopy of beer alcohol content by correlation coefficients and genetic algorithms[J].Transactions of the CSAE,2005,21(7):99-102.
[6]肖君.基于近红外三波长血糖检测系统的研制[D].武汉:华中科技大学,2006:35-40.XIAO Jun.A blood glucose detecting system based on three wavelengths in near-infared region[D].Wuhan:The Huazhong University of Science and Technology,2006:35-40.
[7]余辉.基于浮动基准法的无创血糖检测实验应用研究[J].光谱学与光谱分析,2012,32(3):771-772.YU Hui.Study on the experimental application of floating-reference method to noninvasive blood glucose sensing[J].Spectroscopy and Spectral Analysis,2012,32(3):771-772.
[8]MARUO K,TSURUGI M,CHIN J,et al.Noninvasive blood glucose assay using a newly developed near-infrared spectroscop[J].IEEE Journal of Selected Topics In Quantum Electronics,2003,9(2):322-329.
[9]张虹,孙卫新,金洁.脉搏血氧饱和度监测系统设计中干扰信号的处理方法[J].国外医学:生物医学工程分册,2000,23(2):90-95.ZHANG Hong,SUN Weixin,JIN Jie.Methods of noises elimination in the design of the pulse oximetry system[J].Foreign Medical Sciences:Biomedical Engineering Fascicle,2000,23(2):90-95.
[10]PRINGLE J,UYSTEPRUYST C,ART T,et al.Continuous and non-invasive study of brain oxygenation in the calf by near infrared spectroscopy[J].Research in Veterinary Science,1998,65:239-224.
[11]滕铁超,丁海曙,龚庆成,等.近红外光谱监测体外循环手术中脑组织氧合状况的研究[J].光谱学与光谱分析,2006,26(5):828-831.TENG Tiechao,DING Haishu,GONG Qingcheng,et al.Monitoring cerebral oxygenation using near infrared spectroscopy during cardiopulmonary bypass surgery[J].Spectroscopy and Spectral Analysis,2006,26(5):828-831.
[12]LI Z Y,ZHANG M,WANG Y,et al.Wavelet analysis of cerebral oxygenation signal measured by near infrared spectroscopy in subjects with cerebral infarction[J].Microvascular research,2010,80(1):142-147.
[13]LI Z Y,ZHANG M,WANG Y,et al.Wavelet analysis of sacral tissue oxygenation oscillations by near-infrared spectroscopy in persons with spinal cord injury[J].Microvascular research,2011,81(1):81-87.
[14]陈国强.汽车驾驶员血液酒精含量的近红外光谱法无损检测[D].济南:山东大学,2012.CHEN Guoqiang.Noninvasive analysis of blood alcohol in drivers based on near-infrared spectroscopy[D].Jinan:Shandong University,2012.
[15]罗斯特.人体血液中酒精浓度近红外光谱法无损检测及关键技术[D].济南:山东大学,2013.LUO Site.Noninvasive testing of blood alcohol concentration of body based on near-infrared spectroscopy and its key technology[D].Jinan:Shandong University,2013.
[16]罗斯特,卢丽倩,周伟伟,等.Monte-Carlo仿真酒精特征波长光子在皮肤中的传输规律及光纤探头[J].山东大学学报:理学版,2013,48(1):46-50.LUO Site,LU Liqian,ZHOU Weiwei,et al.MonteCaro simulation of photons transmission at alcohol wavelength in skin tissue and design of fiber optic probe[J].Journal of Shandong University:Natural Science,2013,48(1):46-50.
[17]徐可欣,高峰,赵会娟.生物医学光子学[M].北京:科学出版社,2007.
[18]童诗白,华成英.模拟电子技术基础[M].北京:高等教育出版社,2009:207-208.
[19]曹茂永,王霞,孙农亮.仪用放大器AD620及其应用[J].电测与仪表,2000,37(10):50-51.CAO Maoyong,WANG Xia,SUN Nongliang.Instrumentation amplifier AD620 and its application[J].Electrical Measurement&Instrumentation,2000,37(10):50-51.
[20]王炎.近红外无创血液成分测量——动态光谱检测理论及信号提取方法研究[D].天津:天津大学,2006.WANG Yan.Study on the detect theories and signal acquisition for dynamic spectrum[D].Tianjin:Tianjin University,2006.
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