每日口服10mg阿托伐他汀对原发性高血压合并糖耐量减低患者炎症因子水平影响的临床观察
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摘要
目的观察每日口服10mg阿托伐他汀对原发性高血压(EH)合并IGT患者炎症因子水平的影响。方法 36例EH合并IGT患者(EH+IGT组)口服阿托伐他汀10mg,1次/晚。另选择36例体检者作为对照(NC)组。检测两组FPG、2hPG、胰岛素抵抗指数(HOMA-IR)及血清炎症因子水平的变化。结果 EH+IGT组均完成试验。口服10 mg阿托伐他汀治疗8周BP、2hPG、HOMA-IR、TNF-α及IL-6均下降[BP(159.71±12.25)/(98.67±12.06)vs(131.89±10.72)/(81.76±9.03)mmHg;2hPG(8.39±0.65)vs(6.76±1.19)mmol/L;HOMA-IR(3.11±1.95)vs(2.30±1.25);TNF-α(32.11±5.36)vs(24.29±4.57)ng/L;IL-6(112.37±24.48)vs(70.47±13.30)ng/L](P<0.01)。结论每日口服10mg阿托伐他汀可降低EH合并IGT患者的血清炎症因子水平。
Objective To study the effects of Atorvastatin 10 mg daily on plasma inflammatory cytokines in hypertension patients with impaired glucose tolerance.Methods A total of 36 EH patients with IGT recieved Atorvastatin 10 mg,qn.36 healthy adults served as controls.The levels of fasting blood glucose,postprandial-2-hour blood glucose,HOMA-IR,inflammatory cytokines of each group were tested before and after treatment.Results All the participants in EH +IGT group finished the study.Compared with control group,BP,2hPG,HOMA-IR,TNF-αand IL-6 were decreased significantly[BP(159.71±12.25)/(98.67±12.06)vs(131.89±10.72)/(81.76±9.03)mmHg];2hPG(8.39±0.65)vs(6.76±1.19)mmol/L;HOMA-IR(3.11±1.95)vs(2.30±1.25);TNF-α(32.11±5.36)vs(24.29±4.57)ng/L;IL-6(112.37±24.48)vs(70.47±13.30)ng/L](P<0.01).Conclusion Atorvastatin 10 mg daily could decrease the level of inflammatory cytokines in hypertension patients with impaired glucose tolerance.
Objective To study the effects of Atorvastatin 10 mg daily on plasma inflammatory cytokines in hypertension patients with impaired glucose tolerance.Methods A total of 36 EH patients with IGT recieved Atorvastatin 10 mg,qn.36 healthy adults served as controls.The levels of fasting blood glucose,postprandial-2-hour blood glucose,HOMA-IR,inflammatory cytokines of each group were tested before and after treatment.Results All the participants in EH +IGT group finished the study.Compared with control group,BP,2hPG,HOMA-IR,TNF-αand IL-6 were decreased significantly[BP(159.71±12.25)/(98.67±12.06)vs(131.89±10.72)/(81.76±9.03)mmHg];2hPG(8.39±0.65)vs(6.76±1.19)mmol/L;HOMA-IR(3.11±1.95)vs(2.30±1.25);TNF-α(32.11±5.36)vs(24.29±4.57)ng/L;IL-6(112.37±24.48)vs(70.47±13.30)ng/L](P<0.01).Conclusion Atorvastatin 10 mg daily could decrease the level of inflammatory cytokines in hypertension patients with impaired glucose tolerance.
引文
[1]中国高血压防治指南修订委员会.中国高血压防治指南2010.中华心血管病杂志,2011,39:579-616.
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[4]Sarzani R,Salvi F,Dessi-Fulgheri P,et al.Renin-angiotensin system,natriuretic peptides,obesity,metabolic syndrome,and hypertension:an integrated view in humans.J Hypertens,2008,26:831-843.
[5]Marre M,Leye A.Effects of perindopril in hypertensive patients with or without type 2diabetes mellitus,and with altered insulin sensitivity.Diab Vasc Dis Res,2007,4:163-173.
[6]周斌,蒋晓真,顾哲.吡格列酮对合并代谢综合征的2型糖尿病患者血清炎症因子及胰岛素抵抗的影响.实用医学杂志,2010,26:305-307.
[7]张颖峰,乔雯雯.不同剂量阿托伐他汀对急性冠脉综合征患者血浆CRP水平的影响.中国现代医生,2010,48:44-45.
[8]Pahan K,Sheikh FG,Namboodiri AM,et al.Lovastatin and phenylac-etate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes,microglia,and mac-rophages.J Clin Invest,1997,100:2671-2679.
[9]Castro PF,Miranda R,Verdejo HE,et al.Pleiotropic effects of atorvastatin in heart failure:role in oxidative stress,inflammation,endothelial function,and exercise capacity.J Heart Lung Transplan,2008,27:435-441.
[2]Wang L,Manson JE,Gaziano JM,et al.Circulating inflammatory and endothelial markers and risk of hypertension in white and black postmenopausal women.Clin Chem,2011,57:729-736.
[3]Samoan B,Cathy S,Announcing the 2009Conference:A Preview.Clin Social Work,2008,36:125-126.
[4]Sarzani R,Salvi F,Dessi-Fulgheri P,et al.Renin-angiotensin system,natriuretic peptides,obesity,metabolic syndrome,and hypertension:an integrated view in humans.J Hypertens,2008,26:831-843.
[5]Marre M,Leye A.Effects of perindopril in hypertensive patients with or without type 2diabetes mellitus,and with altered insulin sensitivity.Diab Vasc Dis Res,2007,4:163-173.
[6]周斌,蒋晓真,顾哲.吡格列酮对合并代谢综合征的2型糖尿病患者血清炎症因子及胰岛素抵抗的影响.实用医学杂志,2010,26:305-307.
[7]张颖峰,乔雯雯.不同剂量阿托伐他汀对急性冠脉综合征患者血浆CRP水平的影响.中国现代医生,2010,48:44-45.
[8]Pahan K,Sheikh FG,Namboodiri AM,et al.Lovastatin and phenylac-etate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes,microglia,and mac-rophages.J Clin Invest,1997,100:2671-2679.
[9]Castro PF,Miranda R,Verdejo HE,et al.Pleiotropic effects of atorvastatin in heart failure:role in oxidative stress,inflammation,endothelial function,and exercise capacity.J Heart Lung Transplan,2008,27:435-441.