天然核苷类成分的化学结构和药理活性研究进展
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摘要
核苷类化合物是抗病毒及抗肿瘤方面的热点药物之一,目前关于核苷的合成及检测已有了广泛的研究,但从天然产物中分离报道的核苷类化合物较少。通过对国内外文献调研,本论文从核苷的来源、化学结构以及药理活性等方面进行综述,分析天然核苷的种类特点及药理作用,为核苷类成分的进一步应用和开发研究提供参考。
Nucleosides are one of the hot drugs for antivirus and antitumor. At present,the synthesis and detection of nucleosides have been widely studied,but there are few nucleosides reported from natural products. Through literature research at home and abroad,this paper reviewed the origin,chemical constituents and pharmacological activities of nucleosides,analyzed the characteristics and pharmacological effects of natural nucleosides,and provided reference for the further application and development of nucleosides.
Nucleosides are one of the hot drugs for antivirus and antitumor. At present,the synthesis and detection of nucleosides have been widely studied,but there are few nucleosides reported from natural products. Through literature research at home and abroad,this paper reviewed the origin,chemical constituents and pharmacological activities of nucleosides,analyzed the characteristics and pharmacological effects of natural nucleosides,and provided reference for the further application and development of nucleosides.
引文
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[17]SUN J,JIN M,ZHOU W,et al.A new ribonucleotide from Cordyceps militaris[J].Natural Product Research,2017,31(21):2537-2543.
[18]VOLLER J,ZATLOUKAL M,LENOBEL R,et al.Anticancer activity of natural cytokinins:A structure-activity relationship study[J].Phytochemistry,2010,71(12):1350-1359.
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[25]GAO J,LI W,NIU L,et al.Isolation and structural elucidation of novel antimicrobial compounds from maggots of Chrysomyis megacephala Fabricius[J].Natural Product Research,2015,29(3):239-246.
[26]YANG M L,KUO P C,HWANG T L,et al.Anti-inflammatory principles from Cordyceps sinensis[J].Journal of Natural Products,2011,74(9):1996-2000.
[27]AMEN Y,ZHU Q,TRAN H B,et al.Rho-kinase inhibitors from adlay seeds[J].Natural Product Research,2017:1.
[28]SZUWART M,STARZYSKA E,PIETROWSKABOREK M,et al.Calcium-stimulated guanosine-inosine nucleosidase from yellow lupin(Lupinus luteus)[J].Phytochemistry,2006,67(14):1476-1485.
[29]ABOUHUSSEIN D R,BADR J M,YOUSSEF D T A.Dragmacidoside:a new nucleoside from the red sea sponge Dragmacidon coccinea[J].Natural Product Research,2014,28(15):1134-1141.
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[31]WAFAA H,RUANGELIE E,RAINER E,et al.New alkaloids from the mediterranean Sponge Hamigera hamigera[J].Marine Drugs,2004,2(3):88-100.
[32]PHILIP A.Searle,Tadeusz F.Molinski.Trachycladines A and B:2'-C-Methyl-5'-Deoxy-ribofuranosyl nucleosides from the Marine Sponge Trachycladus laevispirulifer[J].Journal of Organic Chemistry,1995,60:4296-4298.
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[34]CAPON R J,TROTTER N S.N(3),5'-cycloxanthosine,the first natural occurrence of a cyclonucleoside[J].Journal of Natural Products,2005,68(11):1689-1691.
[35]ZHAO J,MA M,WANG S,et al.Bromophenols coupled with derivatives of amino acids and nucleosides from the red alga Rhodomela confervoides[J].Journal of Natural Products,2005,68(5):691-694.
[36]KAZLAUSKAS R,MURPHY P T,WELLS R,et al.Halogenated pyrrolo[2,3-d]pyrimidine nucleosides from marine organisms[J].Australian Journal of Chemistry,1983,36(1):165-170.
[37]BUSH B D,FITCHETT G V,GATES D A,et al.Carbocyclic nucleosides from a species of Saccharothrix[J].Phytochemistry,1993,32(3):737-739.
[38]ZHANG Q,GOULD S J,ZABRISKIE T M.A new cytosine glycoside from Streptomyces griseochromogenes produced by the use in vivo of enzyme inhibitors[J].Journal of Natural Products,1998,61(5):648-651.
[39]KIM J,PORDESIMO E O,TOTH S I,et al.Pantherinine,a cytotoxic aromatic alkaloid,and 7-Deazainosine from the Ascidian Aplidium pantherinum[J].Journal of Natural Products,1993,56(10):1813-1816.
[40]KEYZERS R A,SAMAAI T,DAVIES-COLEMAN M T.Novel pyrroloquinoline ribosides from the South African latrunculid sponge Strongylodesma aliwaliensis[J].Tetrahedron Letters,2004,45(51):9415-9418.
[41]ZHOU X,XU T,WEN K,et al.New N-Acyl Taurine from the sea urchin Glyptocidaris crenularis[M].Bioscience,Biotechnology,and Biochemistry,2010,74(5):1089-1091.
[42]CORRADETTI R,LO C G,MORONI F,et al.Adenosine decreases aspartate and glutamate release from rat hippocampal slices[J].European Journal of Pharmacology,1984,104(1-2):19-26.
[43]MITCHELL SS,POMERANTZ S C,N G P,et al.Tubercidin analogs from the ascidian Didemnum voeltzkowi[J].Journal of Natural Products,1996,59(10):1000-1001.
[44]ZABRISKIE T M,IRELAND C M.The isolation and structure of modified bioactive nucleosides from Jaspis johnstoni[J].Journal of Natural Products,1989,52(6):1353-1356.
[45]WANG D,FENG Y,MURTAZA M,et al.A grand challenge:Unbiased phenotypic function of metabolites from Jaspis splendens against Parkinson's Disease[J].Journal of Natural Products,2016,79(2):353-361.
[46]蒋激扬,刘发.腺苷的抗炎作用[J].中国药理学通报,1998,14(s1):79-82.
[47]HASKOG,SITKOVSKY M V,SZABOC.Immunomodulatory and neuroprotective effects of inosine[J].Trends in Pharmacological Sciences,2004,25(3):152-157.
[48]YU L,ZHAO J,ZHU Q,et al.Macrophage biospecific extraction and high performance liquid chromatography for hypothesis of immunological active components in Cordyceps sinensis[J].Journal of Pharmaceutical&Biomedical Analysis,2007,44(2):439-443.
[49]EVALDSSON C,RYDEN I,UPPUGUNDURI S.Antiinflammatory effects of exogenous uridine in an animal model of lung inflammation[J].International Immunopharmacology,2007,7(8):1025-1032.
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