中医药干预TGF-β1/Smads信号通路对组织器官细胞纤维化调控作用的研究进展
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摘要
转化生长因子-β1(TGF-β1)是一种重要的调节细胞外基质(ECM)积聚的细胞因子,也是目前治疗组织器官细胞纤维化的新靶点。近年来中医药在防治心、肝、肺、肾等组织器官细胞纤维化相关疾病方面取得了较好的临床疗效,随着Smads蛋白家族的研究深入,对各组织器官细胞纤维化发生机制的探讨已进入细胞内信号转导、细胞因子水平,了解转录和转录后水平的细胞内信号通路之间的交叉对话,将使我们能够开发出特异性和有效的治疗方法。因此,探讨中医药对TGF-β1/Smads信号通路的调控作用,将为中医药预防及治疗各组织器官细胞纤维化相关的疾病提供有力依据。就中医药干预TGF-β1/Smads信号通路对心肌纤维化、肝纤维化、肺纤维化、肾脏纤维化及前列腺纤维化的调控作用研究进展进行综述。
TGF-β1 is an important cytokine that regulates the accumulation of extracellular matrix(ECM) and a new target for the treatment of cell fibrosis in tissues and organscurrently. In recent years, traditional Chinese medicine has achieved good clinical results in the prevention and treatment of cell fibrosis-related diseases of heart, liver, lung and kidney. With the deep research of Smads protein family, the mechanism of cell fibrosis in various tissues and organs, exploring the cross-talk between cells that have entered intracellular signal transduction, cytokine levels, and understanding intracellular signaling pathways at the transcriptional and post-transcriptional levels will allow us to develop specific and effective treatments. Therefore, to explore the regulation of TGF-β1/Smads signaling pathway by Chinese medicinewill provide a powerful basis for the prevention and treatment of diseases related to cell fibrosis in various tissues and organs. This article reviews the progress of TCM-β1/Smads signaling pathway in the regulation of myocardial fibrosis, liver fibrosis, pulmonary fibrosis, renal fibrosis and prostate fibrosis.
TGF-β1 is an important cytokine that regulates the accumulation of extracellular matrix(ECM) and a new target for the treatment of cell fibrosis in tissues and organscurrently. In recent years, traditional Chinese medicine has achieved good clinical results in the prevention and treatment of cell fibrosis-related diseases of heart, liver, lung and kidney. With the deep research of Smads protein family, the mechanism of cell fibrosis in various tissues and organs, exploring the cross-talk between cells that have entered intracellular signal transduction, cytokine levels, and understanding intracellular signaling pathways at the transcriptional and post-transcriptional levels will allow us to develop specific and effective treatments. Therefore, to explore the regulation of TGF-β1/Smads signaling pathway by Chinese medicinewill provide a powerful basis for the prevention and treatment of diseases related to cell fibrosis in various tissues and organs. This article reviews the progress of TCM-β1/Smads signaling pathway in the regulation of myocardial fibrosis, liver fibrosis, pulmonary fibrosis, renal fibrosis and prostate fibrosis.
引文
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[8] 赵桂峰,毛静远,吴丽玉,等.芪参益气滴丸抑制大鼠心肌梗死后心肌纤维化及对TGF-β1/Smads通路表达的影响[J].中国中西医结合杂志,2017,37(12):1466-1470.
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[11] 金智生,王东旭,张花治,等.红芪多糖对db/db小鼠糖尿病心肌病TGF-β_1/Smads信号通路影响的实验研究[J].北京中医药大学学报,2017,40(1):20-26.
[12] Zongtao Hu, Feng Qin, Shile Gao,et al. Paeoniflorin exerts protective effect onradiation-induced hepatic fibrosis in rats via TGF-β1/Smads signaling pathway[J]. Am J Transl Res, 2018, 10(3): 1012-1021.
[13] 冯高飞,陈若.疏肝健脾方对非酒精性脂肪性肝炎患者肝纤维化指标的影响[J].辽宁中医杂志,2015,42(12):2357-2359.
[14] 李洁,邱建利,许华.加味茵陈四逆汤对肝纤维化小鼠TGF-β_1/Smads通路的影响[J].中药材,2016,39(10):2339-2342.
[15] 安祯祥,何远利,王敏,等.扶脾柔肝方对肝纤维化大鼠转化生长因子-β1/Smad信号通路的影响[J].中药新药与临床药理,2017,28(5):557-563.
[16] 李水芹,王振兴,李力,等.补阳还五汤大鼠含药血清对肺成纤维细胞TGF-β1及其基因表达的影响[J].中华中医药学刊,2018,36(3):572-575.
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[18] 赵仲雪,庞立健,滑振,等.IPF中医病机“气络失和”与TGF-β_1/Smads信号传导通路活化的相关性探讨[J].中国实验方剂学杂志,2015,21(17):204-207.
[19] 周薇,涂艳.益气活血通络方对博莱霉素致肺纤维化大鼠TGF-β1/Smads信号通路的作用机制研究[J].中国中医急症,2017,26(2):208-211.
[20] 樊茂蓉,韩克华,王冰,等.通肺络补宗气方对特发性肺间质纤维化患者血清TGF-β、TNF-α、CTGF及PDGF的影响[J].辽宁中医杂志,2017,44(12):2572-2575.
[21] 刘勇,王锐,施欣辛,等.TGF-β1/Smads调控与肾脏纤维化治疗研究进展[J].实用中医药杂志,2016,32(10):1041-1042.
[22] 陈凤,LU Zhiwei,戴恩来.中西医对肾纤维化发病机制的研究进展[J].辽宁中医杂志,2016,43(6):1243-1246.
[23] 陈薪薪,仝欢,陈宇,等.白藜芦醇对小鼠肾纤维化TGF-β_1/Smads信号转导通路的干预研究[J].中华中医药学刊,2016,34(5):1224-1227.
[24] 詹继红,何立群,刘铭洁.刺梨黄酮对诱导大鼠肾纤维化TGF-β1/Smads信号转导干预作用及机制分析[J].辽宁中医杂志,2017,44(2):380-383,446.
[25] 邹美南,郑平,李中桂,等.健脾益肾丸对肾脏纤维化大鼠TGF-β1/Smads信号通路相关基因表达的研究[J].河北中医药学报,2017,32(4):7-11.
[26] 中国中西医结合学会男科专业委员会.慢性前列腺炎中西医结合诊疗专家共识[J].中国中西医结合杂志,2015,35(8):933-941.
[27] 朱闽,徐楠,荀建宁,等.建立实验性自身免疫性前列腺炎湿热证病证结合小鼠模型探讨[J].中华中医药学刊,2018,36(3):531-534.
[28] 徐楠,马亚丽,朱闽,等.前列消汤对ⅢA型(湿热挟瘀型)前列腺炎的临床疗效观察[J].中国性科学,2016,25(7):93-95.
[2] Masato Morikawa, Rik Derynck, Kohei Miyazono.TGF-β and the TGF-βFamily:Context-Dependent Roles in Cell and Tissue Physiology[J]. Cold Spring Harb Perspect Biol,2016,8(5): a021873.
[3] Yan X,LiaoH,ChengM,et al.Smad7 Protein Interacts with Receptor-regulated Smads(R-Smads) to Inhibit Transforming Growth Factor-β(TGF-β)/Smad Signaling[J].J Biol Chem, 2016, 291(1): 382-392.
[4] Dabhi B,Mistry KN.Oxidative stress and its association with TNF-a-308 G/C andIL-1a-889 C/Tgene polymorphisms in patients with diabetes and diabeticnephropathy[J].Gene,2015,562(2):197-202.
[5] Chen L, Yang T, Lu DW, et al.Central role of dysregulation of TGF-β/Smad inCKD progression and potential targets of its treatment[J]. Biomed Pharmacother,2018,101:670-681.
[6] Ma Y,Zou H,Zhu XX,et al.Transforming growth factor β: a potential biomarker and therapeutic target of ventricular remodeling[J]. Oncotarget,2017,19:1-11.
[7] Guo Y,Gupte M,Umbarkar P,et al.Entanglement of GSK-3β,β-catenin and TGF-β1 signaling network to =regulate myocardial fibrosis [J].J Mol Cell Cardiol,2017,27(110):109-120.
[8] 赵桂峰,毛静远,吴丽玉,等.芪参益气滴丸抑制大鼠心肌梗死后心肌纤维化及对TGF-β1/Smads通路表达的影响[J].中国中西医结合杂志,2017,37(12):1466-1470.
[9] 蔡倩玮,于远望.中医药防治心肌纤维化的实验研究进展[J].中医药导报,2017,23(1):76-79.
[10] 李少春,马丽娜,陈坚,等.大蒜辣素对大鼠心肌梗死后纤维化的影响及与TGF-β/Smads信号通路的关系[J].中国中药杂志,2016,41(13):2517-2521.
[11] 金智生,王东旭,张花治,等.红芪多糖对db/db小鼠糖尿病心肌病TGF-β_1/Smads信号通路影响的实验研究[J].北京中医药大学学报,2017,40(1):20-26.
[12] Zongtao Hu, Feng Qin, Shile Gao,et al. Paeoniflorin exerts protective effect onradiation-induced hepatic fibrosis in rats via TGF-β1/Smads signaling pathway[J]. Am J Transl Res, 2018, 10(3): 1012-1021.
[13] 冯高飞,陈若.疏肝健脾方对非酒精性脂肪性肝炎患者肝纤维化指标的影响[J].辽宁中医杂志,2015,42(12):2357-2359.
[14] 李洁,邱建利,许华.加味茵陈四逆汤对肝纤维化小鼠TGF-β_1/Smads通路的影响[J].中药材,2016,39(10):2339-2342.
[15] 安祯祥,何远利,王敏,等.扶脾柔肝方对肝纤维化大鼠转化生长因子-β1/Smad信号通路的影响[J].中药新药与临床药理,2017,28(5):557-563.
[16] 李水芹,王振兴,李力,等.补阳还五汤大鼠含药血清对肺成纤维细胞TGF-β1及其基因表达的影响[J].中华中医药学刊,2018,36(3):572-575.
[17] Costabel U.The changing treatment landscape in idiopathic pulmonary fibrosis[J]. European Respiratory Review,2015,24(135):65-68.
[18] 赵仲雪,庞立健,滑振,等.IPF中医病机“气络失和”与TGF-β_1/Smads信号传导通路活化的相关性探讨[J].中国实验方剂学杂志,2015,21(17):204-207.
[19] 周薇,涂艳.益气活血通络方对博莱霉素致肺纤维化大鼠TGF-β1/Smads信号通路的作用机制研究[J].中国中医急症,2017,26(2):208-211.
[20] 樊茂蓉,韩克华,王冰,等.通肺络补宗气方对特发性肺间质纤维化患者血清TGF-β、TNF-α、CTGF及PDGF的影响[J].辽宁中医杂志,2017,44(12):2572-2575.
[21] 刘勇,王锐,施欣辛,等.TGF-β1/Smads调控与肾脏纤维化治疗研究进展[J].实用中医药杂志,2016,32(10):1041-1042.
[22] 陈凤,LU Zhiwei,戴恩来.中西医对肾纤维化发病机制的研究进展[J].辽宁中医杂志,2016,43(6):1243-1246.
[23] 陈薪薪,仝欢,陈宇,等.白藜芦醇对小鼠肾纤维化TGF-β_1/Smads信号转导通路的干预研究[J].中华中医药学刊,2016,34(5):1224-1227.
[24] 詹继红,何立群,刘铭洁.刺梨黄酮对诱导大鼠肾纤维化TGF-β1/Smads信号转导干预作用及机制分析[J].辽宁中医杂志,2017,44(2):380-383,446.
[25] 邹美南,郑平,李中桂,等.健脾益肾丸对肾脏纤维化大鼠TGF-β1/Smads信号通路相关基因表达的研究[J].河北中医药学报,2017,32(4):7-11.
[26] 中国中西医结合学会男科专业委员会.慢性前列腺炎中西医结合诊疗专家共识[J].中国中西医结合杂志,2015,35(8):933-941.
[27] 朱闽,徐楠,荀建宁,等.建立实验性自身免疫性前列腺炎湿热证病证结合小鼠模型探讨[J].中华中医药学刊,2018,36(3):531-534.
[28] 徐楠,马亚丽,朱闽,等.前列消汤对ⅢA型(湿热挟瘀型)前列腺炎的临床疗效观察[J].中国性科学,2016,25(7):93-95.
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