中医药对肝纤维化相关细胞因子的调节作用
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摘要
中医药治疗具有调节肝纤维化因子的优势,是未来治疗肝纤维化药物的候选。归纳了近年来中医药调节肝纤维化相关细胞因子的研究现状,提示中医药通过调节肝纤维化细胞因子对于阻断、逆转肝纤维化具有一定意义。
Traditional Chinese medicine(TCM) therapy has the advantage of regulating cytokines associated with liver fibrosis and is a candidate for the treatment of liver fibrosis in the future. This article summarizes the research advances in the role of TCM in regulating cytokines associated with liver fibrosis and points out that TCM has certain significance in blocking and reversing liver fibrosis by regulating related cytokines.
Traditional Chinese medicine(TCM) therapy has the advantage of regulating cytokines associated with liver fibrosis and is a candidate for the treatment of liver fibrosis in the future. This article summarizes the research advances in the role of TCM in regulating cytokines associated with liver fibrosis and points out that TCM has certain significance in blocking and reversing liver fibrosis by regulating related cytokines.
引文
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[4] ZHU YP,BU SR. New progress in pathogenesis of liver fibrosis[J]. Chin Hepatol,2016,21(5):401-403.(in Chinese)朱亚平,卜淑蕊.肝纤维化发病机制研究新进展[J].肝脏,2016,21(5):401-403.
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[7] KAJDANIUK D,MAREK B,BORGIEL-MAREK H,et al. Transforming growth factorβ1(TGFβ1)in physiology and pathology[J]. Endokrynol Pol,2013,64(5):384-396.
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[9] LI FB,ZHAO H,PENG KR,et al. Expression of transforming growth factor-β1 and connective tissue growth factor in congenital biliary atresia and neonatal hepatitis liver tissue[J]. Genet Mol Res,2016,15(1):gmr. 15017217.
[10] AN ZX,HE YL,WANG M,et al. Effects of Fupi Rougan formula on transforming growth factor-β1/Smads signal pathway in rats with liver fibrosis[J]. Tradit Chin Drug Res Clin Pharmacol,2017,28(5):557-563.(in Chinese)安祯祥,何远利,王敏,等.扶脾柔肝方对肝纤维化大鼠转化生长因子-β1/Smad信号通路的影响[J].中药新药与临床药理,2017,28(5):557-563.
[11] YOU SP,ZHAO J,MUKARAM TDMT,et al. The effects of cistanche phenylethanoid glycosides on TGF-β1 expression of rats with hepatic fibrosis induced by BSA[J]. Carcinog Teratogenesis Mutagen,2015,27(6):409-414.(in Chinese)由淑萍,赵军,木克热木·吐地买提,等.肉苁蓉苯乙醇苷类成分对BSA诱导的肝纤维化大鼠转化生长因子β1表达的影响[J].癌变·畸变·突变,2015,27(6):409-414.
[12] JING J,ZHAO JY,HUA B,et al. Inhibitory effect of flavonoids from Glycyrrhiza uralensis on expressions of TGF-β1 and Caspase-3 in thioacetamide-induced hepatic fibrosis in rats[J]. China J Chin Mater Med,2015,40(15):3034-3040.(in Chinese)景晶,赵金英,华冰,等.甘草总黄酮抑制硫代乙酰胺诱导肝纤维化大鼠肝组织中TGF-β-1及Caspase-3的表达[J].中国中药杂志,2015,40(15):3034-3040.
[13] YANG ZQ,QIN XQ,CHEN Y,et al. Nine kinds of mice infected with hepatitis B virus after liver cirrhosis model[J]. J Changchun Univ Chin Med,2017,33(2):198-200.(in Chinese)杨增强,秦雪琴,陈悦,等.九味肝泰对小鼠感染乙型肝炎病毒后肝硬化模型的干预研究[J].长春中医药大学学报,2017,33(2):198-200.
[14] FRANSIEN VD,PETER O,KLAAS P,et al. Targeted therapies in liver fibrosis:Combining the best parts of platelet-derived growth factor BB and interferon gamma[J]. Front Med(Lausanne),2015,2:72.
[15] KNOP J,APP C,HUFF T,et al. Identification of PDGF-BB binding to thymosinβ4 by chemical cross-linking[J]. Expert Opin Biol Ther,2015,15(Suppl 1):s147-s154.
[16] WANG YH,ZHENG SQ,HUANG XL,et al. Effect of tissue inhibitor of metalloproteinase 1 on recruitment of hepatic macrophages in mice[J]. J Clin Exp Med,2018,17(6):561-564.(in Chinese)王燕红,郑书全,黄小莉,等.基质金属蛋白酶组织抑制因子-1对小鼠肝脏肝脏巨噬细胞募集作用的研究[J].临床和实验医学杂志,2018,17(6):561-564.
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[18] TU J,LING Y,SHOU QY,et al. Effect of rat serum containing biejiajianwan on proliferation and migration of rat hepatic stellate cells induced by PDGF[J]. J Zhejiang Univ Tradit Chin Med,2015,39(2):133-138.(in Chinese)屠珏,凌云,寿旗扬,等.鳖甲煎丸药物血清对PDGF诱导大鼠肝星状细胞增殖及迁移的影响[J].浙江中医药大学学报,2015,39(2):133-138.
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