加巴喷丁联合盐酸羟考酮对晚期癌因性疼痛患者的效果及对其疼痛介质的影响
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摘要
目的分析晚期癌因性疼痛患者治疗中加巴喷丁联合盐酸羟考酮的效果、对疼痛介质的影响。方法选取76例晚期癌因性疼痛患者随机分成参照组37例和观察组39例。参照组给予盐酸羟考酮治疗,观察组给予加巴喷丁联合盐酸羟考酮治疗。比较用药前后两组疼痛评分及疼痛介质水平。结果用药前两组疼痛数字量表(NRS)评分,5-羟色胺(5-HT)、多巴胺(DA)、去甲肾上腺素(NE)水平比较,差异无统计学意义(P>0.05);用药后观察组NRS评分、5-HT、DA、NE分别为(2.30±0.75)分、(682.05±85.93)ng/L、(13254.51±2546.01)ng/L、(468.63±52.74)ng/L,低于参照组的(4.21±0.63)分、(821.17±71.02)ng/L、(15862.01±2634.51)ng/L、(497.30±53.59)ng/L,且两组各项指标均较治疗前降低,差异均有统计学意义(P<0.05)。结论晚期癌因性疼痛患者治疗中加巴喷丁联合盐酸羟考酮可减轻疼痛、降低疼痛介质水平。
Objective To analyze the effect of gabapentin combined with oxycodone hydrochloride in the treatment of patients with advanced cancerinduced pain and its effect on pain media.Methods 76 patients with advanced cancer-induced pain were randomly divided into a reference group of37 patients and an observation group of 39 patients.The reference group was given oxycodone hydrochloride treatment, and the observation group was given gabapentin combined with oxycodone hydrochloride. The pain scores and pain media levels were compared between the two groups before and after medication.Results There were no significant differences in the pain digital scale(NRS) scores, serotonin(5-HT), dopamine(DA) and norepinephrine(NE) levels between the two groups before treatment(P>0.05). The NRS scores, 5-HT, DA, and NE in the post-observation group were(2.30 ±0.75),(682.05 ±85.93) ng/L,(13254.51 ±2546.01) ng/L,(468.63 ±52.74) ng/L,respectively,which was lower than the reference group(4.21 ±0.63),(821.17±71.02) ng/L,(15862.01±2634.51) ng/L,(497.30±53.59) ng/L,and the indexes of the two groups were lower than before treatment,the differences were statistically significant(P<0.05).Conclusion Gabapentin combined with oxycodone hydrochloride in patients with advanced cancer-induced pain can reduce pain and reduce the level of pain media.
Objective To analyze the effect of gabapentin combined with oxycodone hydrochloride in the treatment of patients with advanced cancerinduced pain and its effect on pain media.Methods 76 patients with advanced cancer-induced pain were randomly divided into a reference group of37 patients and an observation group of 39 patients.The reference group was given oxycodone hydrochloride treatment, and the observation group was given gabapentin combined with oxycodone hydrochloride. The pain scores and pain media levels were compared between the two groups before and after medication.Results There were no significant differences in the pain digital scale(NRS) scores, serotonin(5-HT), dopamine(DA) and norepinephrine(NE) levels between the two groups before treatment(P>0.05). The NRS scores, 5-HT, DA, and NE in the post-observation group were(2.30 ±0.75),(682.05 ±85.93) ng/L,(13254.51 ±2546.01) ng/L,(468.63 ±52.74) ng/L,respectively,which was lower than the reference group(4.21 ±0.63),(821.17±71.02) ng/L,(15862.01±2634.51) ng/L,(497.30±53.59) ng/L,and the indexes of the two groups were lower than before treatment,the differences were statistically significant(P<0.05).Conclusion Gabapentin combined with oxycodone hydrochloride in patients with advanced cancer-induced pain can reduce pain and reduce the level of pain media.
引文
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[7]陈栋樑,李玉红,王志娟,等.羟考酮联合加巴喷丁用于重度癌痛患者的长期疗效及满意度[J].中国新药与临床杂志,2017,36(4):47-52.
[8]上官文姬,李展春,程光齐,等.骨碎补总黄酮对绝经后骨质疏松大鼠疼痛介质和疼痛反应影响[J].辽宁中医药大学学报,2017,19(3):12-14.
[2]杨建强,张菊英,罗浩杰,等.五指疼痛评估法在老年带状疱疹患者疼痛评估中的应用[J].中国麻风皮肤病杂志,2018,34(7):1482-1486.
[3]成东华.恶性肿瘤的TNM分期[J].中国实用外科杂志,2004,24(5):317-319.
[4]陈卓园园,韩兴平,鞠梅.癌症患者癌痛自我效能感和生活质量现状调查[J].实用医学杂志,2017,33(4):636-638.
[5]李德辉,孙春霞,范焕芳.复方苦参注射液联合盐酸羟考酮缓释片治疗癌痛的系统评价[J].中国疼痛医学杂志,2017,23(5):98-99.
[6]高宏,殷东风,邢向荣,等.奥施康定联合加巴喷丁治疗癌性神经病理性疼痛的临床疗效及对免疫功能的影响[J].现代生物医学进展,2017,17(23):4479-4482.
[7]陈栋樑,李玉红,王志娟,等.羟考酮联合加巴喷丁用于重度癌痛患者的长期疗效及满意度[J].中国新药与临床杂志,2017,36(4):47-52.
[8]上官文姬,李展春,程光齐,等.骨碎补总黄酮对绝经后骨质疏松大鼠疼痛介质和疼痛反应影响[J].辽宁中医药大学学报,2017,19(3):12-14.