血清Gal-3、C1q水平与冠心病的相关性分析
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摘要
目的分析血清半乳糖凝聚素-3(Gal-3)、补体C1q水平与冠心病的关系及其临床意义。方法收集2014年10月—2018年9月空军军医大学唐都医院心内科因胸痛不适入院治疗的患者134例,根据冠状动脉造影结果分为造影正常(对照)组47例,冠心病组87例,检测所有受试者血清Gal-3、补体C1q、高密度脂蛋白胆固醇(HDLC)和低密度脂蛋白胆固醇(LDL-C)水平及体质量指数(BMI)等指标,分析其与冠心病的关系。结果冠心病组患者血清Gal-3水平高于对照组,C1q水平低于对照组(t/P=15. 761/0. 000、19. 505/0. 000);不同颈动脉内膜中层厚度和斑块类型患者血清Gal-3、C1q水平比较差异有统计学意义(P <0.01);血清Gal-3、LDL水平与冠心病的发生呈正相关(r/P=0. 612/0.005,0.436/0.031),C1q水平与冠心病的发生呈负相关(r/P=-0. 527/0. 000);血清Gal-3、LDL-C水平是冠心病的独立风险因素(OR=6.940、4.267,95%CI=2.540~18.961、1.653~1.1.014), C1q水平为冠心病保护因素(OR=0. 144,95%CI=0. 055~0. 376)。结论血清Gal-3、C1q水平可以反映冠状动脉斑块状态,实时监测患者血清Gal-3、C1q水平有助于预测冠心病的发生并了解其病情。
Objective To analyze the relationship between serum levels of Gal-3 and C1 q and coronary heart disease and its clinical significance. Methods One hundred and thirty four patients with chest pain and discomfort admitted to Tangdu Hospital of Air Force Military Medical University from October 2014 to September 2018 were collected. According to the results of coronary angiography, 47 cases were divided into normal(control) group and 87 cases into coronary heart disease group. Serum galactose agglutinin-3(Gal-3), complement C1 q, high density lipoprotein cholesterol(HDL-C), low density lipoprotein cholesterol(LDL-C) levels and body mass index were measured in all subjects, and the relationship between galactose agglutinin 3, complement C1 q, high density lipoprotein cholesterol(HDL-C), low density lipoprotein cholesterol(LDL-C) and coronary heart disease was analyzed. Results The serum Gal-3 level in patients with coronary heart disease was higher than that in the control group, and the C1 q level was lower than that in the control group(t/P = 15.761/0.000, t/P = 19.505/0.000). Serum Gal-3 in patients with different carotid intima-media thickness and plaque type There was a statistically significant difference in C1 q levels(P<0.01). Serum Gal-3 and LDL-C levels were positively correlated with coronary heart disease(r/P = 0.612/0.005, r/P = 0.436/0.031), C1 q levels and coronary heart disease. The incidence was negatively correlated(r/P =-0.527/0.000); serum Gal-3 and LDL-C levels were independent risk factors for coronary heart disease, and C1 q levels were protective factors for coronary heart disease(OR =6. 940,OR =4. 267, OR =0. 144,95% CI =2.540 to 18.961, 1.653 to 11.014, 0.055 to 0.376). Conclusion Serum levels of Gal-3 and C1 q can reflect the status of coronary plaque. Real-time monitoring of serum levels of Gal-3 and C1 q can help to predict the occurrence of coronary heart disease and understand its condition.
Objective To analyze the relationship between serum levels of Gal-3 and C1 q and coronary heart disease and its clinical significance. Methods One hundred and thirty four patients with chest pain and discomfort admitted to Tangdu Hospital of Air Force Military Medical University from October 2014 to September 2018 were collected. According to the results of coronary angiography, 47 cases were divided into normal(control) group and 87 cases into coronary heart disease group. Serum galactose agglutinin-3(Gal-3), complement C1 q, high density lipoprotein cholesterol(HDL-C), low density lipoprotein cholesterol(LDL-C) levels and body mass index were measured in all subjects, and the relationship between galactose agglutinin 3, complement C1 q, high density lipoprotein cholesterol(HDL-C), low density lipoprotein cholesterol(LDL-C) and coronary heart disease was analyzed. Results The serum Gal-3 level in patients with coronary heart disease was higher than that in the control group, and the C1 q level was lower than that in the control group(t/P = 15.761/0.000, t/P = 19.505/0.000). Serum Gal-3 in patients with different carotid intima-media thickness and plaque type There was a statistically significant difference in C1 q levels(P<0.01). Serum Gal-3 and LDL-C levels were positively correlated with coronary heart disease(r/P = 0.612/0.005, r/P = 0.436/0.031), C1 q levels and coronary heart disease. The incidence was negatively correlated(r/P =-0.527/0.000); serum Gal-3 and LDL-C levels were independent risk factors for coronary heart disease, and C1 q levels were protective factors for coronary heart disease(OR =6. 940,OR =4. 267, OR =0. 144,95% CI =2.540 to 18.961, 1.653 to 11.014, 0.055 to 0.376). Conclusion Serum levels of Gal-3 and C1 q can reflect the status of coronary plaque. Real-time monitoring of serum levels of Gal-3 and C1 q can help to predict the occurrence of coronary heart disease and understand its condition.
引文
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[15]王博,葛兴利,方顺淼,等.血清Gal-3与慢性心力衰竭的相关性及其临床意义[J].海南医学,2017, 28(17):2776-2778.DOI:10.3969/j. issn. 1003-6350.2017. 17.007.
[16]吴多宏,吴淼,李明,等.血浆AT-Ⅲ、CD93水平与冠心病患者非高密度脂蛋白水平和Gensini评分的关系研究[J].疑难病杂志,2018,17(12):1301-1305. DOI:10. 3969/j. issn. 1671-6450.2018.12.002.
[17]郭晓斌,王鹏,陶立元,等.颈动脉粥样斑块形成的影响因素研究[J].中国全科医学,2018,21(17):2043-2047.DOI:10.3969/j. issn. 1007-9572.2018.00.214.
[18]汪秀莲,赵韧,王邦宁.血清半乳糖凝集素-3及炎症因子与冠脉病变程度和主要心脏不良事件的相关性[J].安徽医科大学学报,2017, 52(2):261-264. DOI:10. 19405/j. cnki. issn1000-1492.2017.02.025.
[19]匡圆圆,马琦琳,张赛丹.血清补体Clq水平与老年患者冠状动脉狭窄程度的相关性研究[J].临床心血管病杂志,2018, 34(11):1077-1080. DOI:10. 13201/j. issn. 1001-1439. 2018. 11.010.
[20]朱小莉,周云,孙晓靖.冠心病危险因素分析及其与冠状动脉狭窄程度的关系[J].中国循证心血管医学杂志,2017,9(12):1513-1515. DOI:10.3969/j. issn. 1674-4055.2017.12.30.
[2]顾丽萍,胡菁,严蜀华.美托洛尔与曲美他嗪治疗老年冠心病心力衰竭的疗效及对患者心功能、心肌重塑和炎症因子的影响[J].中国老年学杂志,2017,37(1):89-91.DOI:10.3969/j.issn.1005-9202.2017.01.038.
[3]吴冰洁,蒋晶晶,李晓牧,等.绝经后女性骨代谢标志物与冠心病、冠状动脉粥样硬化病变程度相关性的初步研究[J].中华内分泌代谢杂志,2016, 32(11):928-933. DOI:10.3760/cma.j.issn. 1000-6699. 2016.11.008.
[4] Li X, Zheng Y, Long Y, et al. Effect of iloprost on biomarkers in patients with congenital heart disease-pulmonary arterial hypertension[J]. Clinical&Experimental Pharmacology&Physiology, 2017,44(9):914-923. DOI:10.1111/1440-1681.12796.
[5]李伟.在阿尔兹海默病小鼠模型中补体和小胶质细胞介导了早期突触丢失[J].中国病理生理杂志,2017,33(3):422. DOI:10. 3969/j. issn. 1000-4718. 2017.03.007.
[6]汪秀莲,赵韧,王邦宁.血清半乳糖凝集素-3及炎症因子与冠脉病变程度和主要心脏不良事件的相关性[J].安徽医科大学学报,2017, 52(2):261-264. DOI:10. 19405/j. cnki. issn1000-1492.2017.02.025.
[7]吴毅琴,陈波,朱常青,等.冠状动脉CT造影结合颈动脉超声与血清学标志物评价2型糖尿病合并冠心病的临床意义[J].中国糖尿病杂志,2016,24(10):908-913. DOI:10.3969/j.issn.1006-6187.2016.10.07.
[8]王丹,亓恒涛,孙书珍,等.原发性肾病综合征儿童颈动脉结构和功能改变[J].山东大学学报:医学版,2016, 54(5):88-91.DOI:10.6040/j. issn. 1671-7554.0.2015.927.
[9]杜京奚,张雅君,段云友,等.颈动脉粥样硬化斑块稳定性与连接黏附分子A相关性的实验研究[J].中华超声影像学杂志,2016, 25(4):345-350. DOI:10. 3760/cma. j. issn. 1004-4477.2016.04.016.
[10] Gimbrone MA Jr, Garcia-Cardena G. Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis[J]. Circulation Research,2016, 118(4):620-636. DOI:10. 1161/CIRCRESAHA. 115.306301.
[11] Barbato E, Toth GG, Johnson NP,et al. A Prospective Natural History Study of Coronary Atherosclerosis Using Fractional Flow Reserve[J]. Journal of the American College of Cardiology, 2016, 68(21):2247-2255. DOI:10.1016/j. jacc.2016.08.055.
[12] Stubbs JR, House JA, Ocque AJ, et al. Serum Trimethylamine-NOxide is Elevated in CKD and Correlates with Coronary Atherosclerosis Burden[J]. Journal of the American Society of Nephrology Jasn,2016, 27(1):305-313. DOI:10. 1681/ASN.2014111063.
[13]查晴,曹丽娟,王燕萍,等.oxLDL通过TLR4诱导脂质累积和炎症反应促进动脉粥样硬化的分子机制[J].上海交通大学学报(医学版),2017, 37(5):611-615. DOI:10.3969/j. issn. 1674-8115.2017.05.008.
[14]赵雁,王红巧,李建英,等.血清Gal-3联合NT-proBNP预测慢性肾脏病合并心力衰竭的价值[J].山东医药,2018, 58(41):75-78. DOI:10.3969/j. issn. 1002-266X. 2018.41.020.
[15]王博,葛兴利,方顺淼,等.血清Gal-3与慢性心力衰竭的相关性及其临床意义[J].海南医学,2017, 28(17):2776-2778.DOI:10.3969/j. issn. 1003-6350.2017. 17.007.
[16]吴多宏,吴淼,李明,等.血浆AT-Ⅲ、CD93水平与冠心病患者非高密度脂蛋白水平和Gensini评分的关系研究[J].疑难病杂志,2018,17(12):1301-1305. DOI:10. 3969/j. issn. 1671-6450.2018.12.002.
[17]郭晓斌,王鹏,陶立元,等.颈动脉粥样斑块形成的影响因素研究[J].中国全科医学,2018,21(17):2043-2047.DOI:10.3969/j. issn. 1007-9572.2018.00.214.
[18]汪秀莲,赵韧,王邦宁.血清半乳糖凝集素-3及炎症因子与冠脉病变程度和主要心脏不良事件的相关性[J].安徽医科大学学报,2017, 52(2):261-264. DOI:10. 19405/j. cnki. issn1000-1492.2017.02.025.
[19]匡圆圆,马琦琳,张赛丹.血清补体Clq水平与老年患者冠状动脉狭窄程度的相关性研究[J].临床心血管病杂志,2018, 34(11):1077-1080. DOI:10. 13201/j. issn. 1001-1439. 2018. 11.010.
[20]朱小莉,周云,孙晓靖.冠心病危险因素分析及其与冠状动脉狭窄程度的关系[J].中国循证心血管医学杂志,2017,9(12):1513-1515. DOI:10.3969/j. issn. 1674-4055.2017.12.30.