调脂柔脉颗粒对症状性颈动脉粥样硬化血脂及颈内膜作用的临床研究
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摘要
目的探讨调脂柔脉颗粒对症状性颈动脉粥样硬化的血脂及颈动脉内膜的影响。方法将90例颈动脉粥样硬化的患者随机分为治疗组和对照组,治疗组60例,对照组30例,对照组给予阿托伐他汀钙和阿司匹林肠溶片治疗,治疗组在对照组基础上加用脂柔脉颗粒,共12周,观察血脂、颈动脉B超。结果两组的双侧颈动脉IMT厚度较治疗前均有所减少(P <0. 05),组间比较无明显差异(P> 0. 05);两组颈动脉粥样硬化Crouse积分经治疗后均呈下降趋势,组间比较无显著差异(P> 0. 05),治疗组TC、LDL-C改善方面优于对照组,差异有统计学意义(P <0. 05)。结论调脂柔脉颗粒联合西药能降低颈动脉粥样硬化患者的血脂水平,延缓颈动脉硬化的发展。
Objective: To treat the effect of Tiaozhi Roumai Granules on blood lipid and carotid artery intima of symptomatic carotid atherosclerosis. Method: 90 cases of carotid atherosclerosis were randomly divided into treatment group( 60 cases) and control group( 30 cases). The control group was treated with Atorvastatin Calcium and Aspirin Enteric-coated Tablets,and the treatment group was treated with Tiaozhi Roumai Granules on the basis of the control group. After 12 weeks,the blood lipids were measured and B-scan ultrasonography of the carotid arteries were applied in both groups. Result: IMT in bilateral carotid arteries was significantly lower than that before treatment( P < 0. 05),and there was no significant difference between the two groups( P > 0. 05). Carrouse scores of carotid atherosclerosis in both groups showed a downward trend after treatment,and there was no significant difference between the two groups( P > 0. 05). The improvement of TC and LDL-C in the treatment group was better than that in the control group,and the difference was statistically significant( P < 0. 05). Conclusion: Tiaozhi Roumai Granules combined with Western medicine can reduce blood lipid levels in patients with carotid atherosclerosis and delay the development of carotid atherosclerosis.
Objective: To treat the effect of Tiaozhi Roumai Granules on blood lipid and carotid artery intima of symptomatic carotid atherosclerosis. Method: 90 cases of carotid atherosclerosis were randomly divided into treatment group( 60 cases) and control group( 30 cases). The control group was treated with Atorvastatin Calcium and Aspirin Enteric-coated Tablets,and the treatment group was treated with Tiaozhi Roumai Granules on the basis of the control group. After 12 weeks,the blood lipids were measured and B-scan ultrasonography of the carotid arteries were applied in both groups. Result: IMT in bilateral carotid arteries was significantly lower than that before treatment( P < 0. 05),and there was no significant difference between the two groups( P > 0. 05). Carrouse scores of carotid atherosclerosis in both groups showed a downward trend after treatment,and there was no significant difference between the two groups( P > 0. 05). The improvement of TC and LDL-C in the treatment group was better than that in the control group,and the difference was statistically significant( P < 0. 05). Conclusion: Tiaozhi Roumai Granules combined with Western medicine can reduce blood lipid levels in patients with carotid atherosclerosis and delay the development of carotid atherosclerosis.
引文
[1]中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组.中国脑血管疾病分类2015[J].中华神经科杂志,2017,50(3):168-171.
[2]杨志宏,李经渭,袁有才,等.调脂柔脉颗粒对高脂血症大鼠动脉壁ICAM-1基因表达的影响[J].陕西中医,2016,37(5):630-631.
[3]杨志宏,许红,杨耀峰.调脂柔脉颗粒对实验性高脂血症模型大鼠血脂、血流变的影响[J].西部中医药,2016,29(9):12-14.
[4]何文.颈动脉彩色多普勒超声与临床[M].北京:科学技术文献出版社,2007:57-58.
[5]潘利红.阿托伐他汀钙治疗脑动脉硬化的临床效果分析[J].中国动脉硬化杂志,2014,22(7):711-714.
[6]龙宜武,唐明,龙强,等.脑心通胶囊联合阿托伐他汀钙对老年颈动脉粥样硬化斑块的影响[J].长春中医药大学学报,2014,30(1):109-111.
[2]杨志宏,李经渭,袁有才,等.调脂柔脉颗粒对高脂血症大鼠动脉壁ICAM-1基因表达的影响[J].陕西中医,2016,37(5):630-631.
[3]杨志宏,许红,杨耀峰.调脂柔脉颗粒对实验性高脂血症模型大鼠血脂、血流变的影响[J].西部中医药,2016,29(9):12-14.
[4]何文.颈动脉彩色多普勒超声与临床[M].北京:科学技术文献出版社,2007:57-58.
[5]潘利红.阿托伐他汀钙治疗脑动脉硬化的临床效果分析[J].中国动脉硬化杂志,2014,22(7):711-714.
[6]龙宜武,唐明,龙强,等.脑心通胶囊联合阿托伐他汀钙对老年颈动脉粥样硬化斑块的影响[J].长春中医药大学学报,2014,30(1):109-111.