液体样品中雌激素活性物质检测方法概述
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摘要
雌激素是一类广泛存在于环境中的类固醇类化学物,不仅直接影响到人类和动物的繁殖与代谢,而且在进入机体后,可干扰体内正常分泌物的合成、释放、运转、代谢及结合,极低浓度的雌激素就可能对动物和人类的生殖系统、神经系统和免疫系统造成严重伤害。研究显示牛奶产品及生活用水与工业水源中都广泛存在着雌激素活性物质,文章着重概述了转基因生物反应器检测方法的研究进展与应用,以及高效液相色谱、气相色谱和其他检测方法在雌激素检测方面的发展应用。
Estrogen are a class of steroid chemicals that are widely found in the environment,which not only impacts the reproduction and metabolism of human and animals directly,but interferes with the synthesis,release,operation,metabolism,and combination of normal secretions after entering the body. Moreover,estrogen may cause serious damage to the reproductive and nervous system and immune system of animals and humans with low concentration. Studies have shown that estrogen active substances are widely found in milk products,domestic water and industrial water sources. The review focused on the research progress and application of genetically modified organism bioreactor detection methods,as well as the development and application of high performance liquid chromatography,gas chromatography and other detection methods in estrogen detection.
Estrogen are a class of steroid chemicals that are widely found in the environment,which not only impacts the reproduction and metabolism of human and animals directly,but interferes with the synthesis,release,operation,metabolism,and combination of normal secretions after entering the body. Moreover,estrogen may cause serious damage to the reproductive and nervous system and immune system of animals and humans with low concentration. Studies have shown that estrogen active substances are widely found in milk products,domestic water and industrial water sources. The review focused on the research progress and application of genetically modified organism bioreactor detection methods,as well as the development and application of high performance liquid chromatography,gas chromatography and other detection methods in estrogen detection.
引文
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[2]Samavat H,Kurzer M S.Estrogen metabolism and breast cancer[J].CANCER LETTERS,2015,356(2):231-243
[3]Key T,Appleby P,Barnes I,et al.Endogenous Sex Hormones and Breast Cancer in Postmenopausal Women:Reanalysis of Nine Prospective Studies[J].CancerSpectrum Knowledge Environment,2002,105(5):709-722
[4]Fuhrman B J,Schairer C,Gail M H,et al.Estrogen metabolism and risk of breast cancer in postmenopausal women[J].JNCI:Journal of the National Cancer Institute,2012,104(4):326-339
[5]Qin L Q,Wang P Y,Kaneko T,et al.Estrogen:one of the risk factors in milk for prostate cancer[J].Medical Hypotheses,2004,62(1):133-142
[6]Kosti O,Goldman L,Bebu I,et al.Abstract 2794:Urinary estrogen metabolites and prostate cancer risk:A case control analysis using healthy and biopsy controls[C].Chicago:AACR,2010
[7]Astarita C,D'Angelomaansson B,Massarogiordano M,et al.Effect of sex steroid hormone fluctuations in the pathophysiology of maleretinal pigment epithelial cells[J].JPURNAL OF CELLULAR PHY-SIOLOGY,2018,223(9):6965-6974
[8]崔浩,张扬,周鸿立.农产品及农业废弃物中雌激素检测方法的研究[J].吉林农业,2016(21):77
[9]Black D,Reilly C F.Inflammatory mechanisms in Atherosclerosis,Glaxo-Wellcome Medicines Research Centre,Stevenage,Herts,UK,3rd July 1995[J].Inflammation research:official journal of the European Histamine Research Society,1997,46(7):237-241
[10]Brix R,Noguerol T N,Pia B,et al.Evaluation of the suitability of recombinant yeast-based estrogenicity assays as a pre-screening tool in environmental samples[J].Environment International,2010,36(4):361-367
[11]Dias A C V,Gomes F W,Bila D M,et al.Analysis of estrogenic activity in environmental waters in Rio de Janeiro state(Brazil)using the yeast estrogen screen[J].Ecotoxicology and Environmental Safety,2015,120:41-47
[12]Beck I C,Bruhn R,Gandrass J.Analysis of estrogenic activity in coastal surface waters of the Baltic Sea using the yeast estrogen screen[J].Chemosphere,2006,63(11):1870-1878
[13]Xu H R,Luo F N,Zhang J,et al.Development of a rapid screening and surveillance for estrogenic chemicals in environment based on recombinant yEGFP yeast cell[J].Toxicology in Vitro,2010,24(4):1285-1291
[14]Stypua-Tr bas S,Minta M,Radko L,et al.Application of the yeastbased reporter gene bioassay for the assessment of estrogenic activity in cow's milk from Poland[J].Environmental Toxicology and Pharmacology,2015,40(3):876-885
[15]Salste L,Leskinen P,Virta M,et al.Determination of estrogens and estrogenic activity in waste-water effluent by chemical analysis and the bioluminescent yeast assay[J].The Science of the Total Enviroment,2007,378(3):343-351
[16]Zutz C,Wagener K,Yankova D,et al.A robust high-throughput fungal biosensor assay for the detection of estrogen activity[J].Steroids,2017,126:57-65
[17]Hahn T,Tag K,Riedel K,et al.A novel estrogen sensor based on recombinant Arxula adeninivorans cells[J].Biosensors&Bioelectronics,2006,21(11):2078-2085
[18]Yan Q,Yang L,Li S.Solid-Phase Extraction Combined with High Performance Liquid Chromatography-Diode Array Detector for Rapid Determination of Estrogens in Milk[J].Tropical Journal of Pharmaceutical Research,2015,14(11):2077-2082
[19]丁郭影.牛奶中三种雌激素的微波辅助提取及其高效液相色谱串联检测[D].合肥:安徽农业大学,2014
[20]刘敏,岳波,尹平河,等.猪粪中典型类固醇雌激素的固相萃取/GC-MS检测[J].环境科学研究,2011,24(7):763-768
[21]Wang X Q,Feng J J,Feng J Q,et al.Basalt fibers coated with nanocalcium carbonate for in-tube solid-phase microextraction and online analysis of estrogens coupled with high-performance liquid chromatography[J].Analytical Methods,2018,10(19):2234-2241
[22]Gao G H,Li S,Li S J,et al.Development and application of vortexassisted membrane extraction based on metal-organic framework mixed-matrix membrane for the analysis of estrogens in human urine[J].Analytica Chimica Acta,2018,1023:35-43
[23]Basheer C,Jayaraman A,Kee M K,et al.Polymer-coated hollow-fiber microextraction of estrogena in water samples with analysis by gas chromatography-mass spectrometry[J].Journal of Chromatography A,2005,1100(2):137-143
[24]Zhou Y,Zhou J,Xu Y,et al.An alternative method for the determination of estrogens in surface water and wastewater treatment plant effluent using precolumn trimethylsilyl derivatization and gas chromatography/mass spectrometry[J].Environmental Monitoring&Assessment,2009(1/4):35-49
[25]廖涛,吴晓翠,王少华,等.固相萃取-气相色谱/质谱联用法同时检测水体中9种环境雌激素[J].分析化学,2013,41(3):422-426
[26]Rocha M J,Cruzeiro C,Reis M,et al.Toxicological relevance of endocrine disruptors in the Tagus River estuary(Lisbon,Portugal)[J].Environmental Monitoring and Assessment,2015,187(8):483
[27]赵淑平,何栩翊,卢静,等.拉曼光谱检测技术应用[J].科技经济市场,2018(1):1-2
[28]冯超,董鹍,吴永军,等.拉曼技术应用于雌激素检测的研究[J].光谱学与光谱分析,2011,31(8):2127-2130
[29]Liu Y,Chen Y,Zhang Y Y,et al.Detection and identification of estrogen based on surface-enhanced resonance Raman scattering(SERRS)[J].Molecules,2018,23(6):1330
[30]艾锦云.化学发光法大气NO_x监测仪器系统优化设计[D].广州:华南师范大学,2004
[31]谢良枭.化学发光分析方法研究及其在雌激素检测中的应用[D].济南:济南大学,2013
[32]Beitollahi H,Tajik S.Construction of a nanostructure-based electrochemical sensor for voltammetric determination of bisphenol A[J].Environ Monit Assess,2015,187(5):257
[33]Zhu L,Cao Y,Cao G.Electrochemical sensor based on magnetic molecularly imprinted nanoparticles at surfactant modifiedmagnetic electrode for determination of bisphenol A[J].Biosens Bioelectron,2014,54(15):258-261
[34]刘俊秋,罗贵民,沈家骢.分子印迹聚合物及其应用[J].功能高分子学报,1998,11(4):561-565
[35]张淑琼,杨黄浩,庄峙厦,等.分子印迹SiO2纳米管膜的制备及其生化分离应用[J].高等学校化学学报,2004(6):1028-1030
[36]马金余,陈波,姚守拙,等.己烯雌酚印迹分子聚合物合成及其在残留分析中的应用[J].分析化学,2005(10):1413-1416
[37]Wang Z,Guo L,Liu L,et al.Colloidal gold-based immunochromatographic strip assay for rapid detection of three natural estrogens in milk[J].Food Chemistry,2018(259):122-129
[38]唐语谦,钟凤,陈艺,等.玉米赤霉烯酮生物脱毒及关键酶作用机理的研究进展[J].现代食品科技,2013,29(7):1742-1746
[39]陈艺,朱珍,吴晖,等.过氧化物酶A4-Prx在毕赤酵母中的优化表达[J].现代食品科技,2014,30(5):209-217
[40]钟凤,吴晖,刘思利,等.可降解玉米赤霉烯酮的重组过氧化物酶A4-Prx的纯化与活性研究[J].现代食品科技,2015,31(8):65-70
[41]吴晖,肖俊梅,陈艺,等.重组过氧化物酶A4-Prx酶学特性及其降解DDGS中ZEN的研究[J].食品工业科技,2012,33(22):213-217
[42]Yu Y S,Qiu L P,Wu H,et al.Degradation of zearalenone by the extracellular extracts of Acinetobacter sp.SM04 liquid cultures[J].Biodegradation,2011,22(3):613-622
[43]Tang Y Q,Xiao J M,Chen Y,et al.Secretory expression and characterization of a novel peroxiredoxin for zearalenone detoxification in Saccharomyces cerevisiae[J].Microbiological Research,2013,168(1):6-11
[44]Yu Y,Qiu L,Wu H,et al.Oxidation of zearalenone by extracellular enzymes from Acinetobacter sp.SM04 into smaller estrogenic products[J].World Journal of Microbiology&Biotechnology,2011,27(11):2675-2681
[2]Samavat H,Kurzer M S.Estrogen metabolism and breast cancer[J].CANCER LETTERS,2015,356(2):231-243
[3]Key T,Appleby P,Barnes I,et al.Endogenous Sex Hormones and Breast Cancer in Postmenopausal Women:Reanalysis of Nine Prospective Studies[J].CancerSpectrum Knowledge Environment,2002,105(5):709-722
[4]Fuhrman B J,Schairer C,Gail M H,et al.Estrogen metabolism and risk of breast cancer in postmenopausal women[J].JNCI:Journal of the National Cancer Institute,2012,104(4):326-339
[5]Qin L Q,Wang P Y,Kaneko T,et al.Estrogen:one of the risk factors in milk for prostate cancer[J].Medical Hypotheses,2004,62(1):133-142
[6]Kosti O,Goldman L,Bebu I,et al.Abstract 2794:Urinary estrogen metabolites and prostate cancer risk:A case control analysis using healthy and biopsy controls[C].Chicago:AACR,2010
[7]Astarita C,D'Angelomaansson B,Massarogiordano M,et al.Effect of sex steroid hormone fluctuations in the pathophysiology of maleretinal pigment epithelial cells[J].JPURNAL OF CELLULAR PHY-SIOLOGY,2018,223(9):6965-6974
[8]崔浩,张扬,周鸿立.农产品及农业废弃物中雌激素检测方法的研究[J].吉林农业,2016(21):77
[9]Black D,Reilly C F.Inflammatory mechanisms in Atherosclerosis,Glaxo-Wellcome Medicines Research Centre,Stevenage,Herts,UK,3rd July 1995[J].Inflammation research:official journal of the European Histamine Research Society,1997,46(7):237-241
[10]Brix R,Noguerol T N,Pia B,et al.Evaluation of the suitability of recombinant yeast-based estrogenicity assays as a pre-screening tool in environmental samples[J].Environment International,2010,36(4):361-367
[11]Dias A C V,Gomes F W,Bila D M,et al.Analysis of estrogenic activity in environmental waters in Rio de Janeiro state(Brazil)using the yeast estrogen screen[J].Ecotoxicology and Environmental Safety,2015,120:41-47
[12]Beck I C,Bruhn R,Gandrass J.Analysis of estrogenic activity in coastal surface waters of the Baltic Sea using the yeast estrogen screen[J].Chemosphere,2006,63(11):1870-1878
[13]Xu H R,Luo F N,Zhang J,et al.Development of a rapid screening and surveillance for estrogenic chemicals in environment based on recombinant yEGFP yeast cell[J].Toxicology in Vitro,2010,24(4):1285-1291
[14]Stypua-Tr bas S,Minta M,Radko L,et al.Application of the yeastbased reporter gene bioassay for the assessment of estrogenic activity in cow's milk from Poland[J].Environmental Toxicology and Pharmacology,2015,40(3):876-885
[15]Salste L,Leskinen P,Virta M,et al.Determination of estrogens and estrogenic activity in waste-water effluent by chemical analysis and the bioluminescent yeast assay[J].The Science of the Total Enviroment,2007,378(3):343-351
[16]Zutz C,Wagener K,Yankova D,et al.A robust high-throughput fungal biosensor assay for the detection of estrogen activity[J].Steroids,2017,126:57-65
[17]Hahn T,Tag K,Riedel K,et al.A novel estrogen sensor based on recombinant Arxula adeninivorans cells[J].Biosensors&Bioelectronics,2006,21(11):2078-2085
[18]Yan Q,Yang L,Li S.Solid-Phase Extraction Combined with High Performance Liquid Chromatography-Diode Array Detector for Rapid Determination of Estrogens in Milk[J].Tropical Journal of Pharmaceutical Research,2015,14(11):2077-2082
[19]丁郭影.牛奶中三种雌激素的微波辅助提取及其高效液相色谱串联检测[D].合肥:安徽农业大学,2014
[20]刘敏,岳波,尹平河,等.猪粪中典型类固醇雌激素的固相萃取/GC-MS检测[J].环境科学研究,2011,24(7):763-768
[21]Wang X Q,Feng J J,Feng J Q,et al.Basalt fibers coated with nanocalcium carbonate for in-tube solid-phase microextraction and online analysis of estrogens coupled with high-performance liquid chromatography[J].Analytical Methods,2018,10(19):2234-2241
[22]Gao G H,Li S,Li S J,et al.Development and application of vortexassisted membrane extraction based on metal-organic framework mixed-matrix membrane for the analysis of estrogens in human urine[J].Analytica Chimica Acta,2018,1023:35-43
[23]Basheer C,Jayaraman A,Kee M K,et al.Polymer-coated hollow-fiber microextraction of estrogena in water samples with analysis by gas chromatography-mass spectrometry[J].Journal of Chromatography A,2005,1100(2):137-143
[24]Zhou Y,Zhou J,Xu Y,et al.An alternative method for the determination of estrogens in surface water and wastewater treatment plant effluent using precolumn trimethylsilyl derivatization and gas chromatography/mass spectrometry[J].Environmental Monitoring&Assessment,2009(1/4):35-49
[25]廖涛,吴晓翠,王少华,等.固相萃取-气相色谱/质谱联用法同时检测水体中9种环境雌激素[J].分析化学,2013,41(3):422-426
[26]Rocha M J,Cruzeiro C,Reis M,et al.Toxicological relevance of endocrine disruptors in the Tagus River estuary(Lisbon,Portugal)[J].Environmental Monitoring and Assessment,2015,187(8):483
[27]赵淑平,何栩翊,卢静,等.拉曼光谱检测技术应用[J].科技经济市场,2018(1):1-2
[28]冯超,董鹍,吴永军,等.拉曼技术应用于雌激素检测的研究[J].光谱学与光谱分析,2011,31(8):2127-2130
[29]Liu Y,Chen Y,Zhang Y Y,et al.Detection and identification of estrogen based on surface-enhanced resonance Raman scattering(SERRS)[J].Molecules,2018,23(6):1330
[30]艾锦云.化学发光法大气NO_x监测仪器系统优化设计[D].广州:华南师范大学,2004
[31]谢良枭.化学发光分析方法研究及其在雌激素检测中的应用[D].济南:济南大学,2013
[32]Beitollahi H,Tajik S.Construction of a nanostructure-based electrochemical sensor for voltammetric determination of bisphenol A[J].Environ Monit Assess,2015,187(5):257
[33]Zhu L,Cao Y,Cao G.Electrochemical sensor based on magnetic molecularly imprinted nanoparticles at surfactant modifiedmagnetic electrode for determination of bisphenol A[J].Biosens Bioelectron,2014,54(15):258-261
[34]刘俊秋,罗贵民,沈家骢.分子印迹聚合物及其应用[J].功能高分子学报,1998,11(4):561-565
[35]张淑琼,杨黄浩,庄峙厦,等.分子印迹SiO2纳米管膜的制备及其生化分离应用[J].高等学校化学学报,2004(6):1028-1030
[36]马金余,陈波,姚守拙,等.己烯雌酚印迹分子聚合物合成及其在残留分析中的应用[J].分析化学,2005(10):1413-1416
[37]Wang Z,Guo L,Liu L,et al.Colloidal gold-based immunochromatographic strip assay for rapid detection of three natural estrogens in milk[J].Food Chemistry,2018(259):122-129
[38]唐语谦,钟凤,陈艺,等.玉米赤霉烯酮生物脱毒及关键酶作用机理的研究进展[J].现代食品科技,2013,29(7):1742-1746
[39]陈艺,朱珍,吴晖,等.过氧化物酶A4-Prx在毕赤酵母中的优化表达[J].现代食品科技,2014,30(5):209-217
[40]钟凤,吴晖,刘思利,等.可降解玉米赤霉烯酮的重组过氧化物酶A4-Prx的纯化与活性研究[J].现代食品科技,2015,31(8):65-70
[41]吴晖,肖俊梅,陈艺,等.重组过氧化物酶A4-Prx酶学特性及其降解DDGS中ZEN的研究[J].食品工业科技,2012,33(22):213-217
[42]Yu Y S,Qiu L P,Wu H,et al.Degradation of zearalenone by the extracellular extracts of Acinetobacter sp.SM04 liquid cultures[J].Biodegradation,2011,22(3):613-622
[43]Tang Y Q,Xiao J M,Chen Y,et al.Secretory expression and characterization of a novel peroxiredoxin for zearalenone detoxification in Saccharomyces cerevisiae[J].Microbiological Research,2013,168(1):6-11
[44]Yu Y,Qiu L,Wu H,et al.Oxidation of zearalenone by extracellular enzymes from Acinetobacter sp.SM04 into smaller estrogenic products[J].World Journal of Microbiology&Biotechnology,2011,27(11):2675-2681