醒脑静、654-2联合纳洛酮治疗重度急性酒精中毒的疗效观察

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英文篇名：Observation on the Therapeutic Effect of Xingnaojing, 654-2 Combined with Naloxone in the Treatment of Severe Acute Alcoholism 作者：吴少文 ; 马剑锋 ; 林欣庚 英文作者：WU Shaowen;MA Jianfeng;LIN Xingeng;Puning People's Hospital; 关键词：重度急性酒精中毒 ; 醒脑静 ; 654-2 ; 纳洛酮 ; 疗效 英文关键词：Severe acute alcoholism;;Xingnaojing;;654-2;;Naloxone;;Therapeutic effect 中文刊名：YBQJ 英文刊名：Clinical Medicine & Engineering 机构：普宁市人民医院; 出版日期：2019-06-15 出版单位：临床医学工程 年：2019 期：v.26;No.244 语种：中文; 页：YBQJ201906035 页数：2 CN：06 ISSN：44-1655/R 分类号：75-76

摘要

目的探讨醒脑静、 654-2联合纳洛酮治疗重度急性酒精中毒的临床治疗效果。方法将2012年1月至2017年12月我院收治的60例重度急性酒精中毒患者作为研究对象,随机分为研究组和对照组各30例。对照组患者采用纳洛酮进行治疗,研究组在对照组基础上加用654-2及醒脑静联合治疗。比较两组患者的苏醒时间、症状消失时间、临床治疗效果以及不良反应。结果研究组患者的苏醒时间及症状消失时间分别为(75.18±10.74) min、(255.18±50.72) min,均显著短于对照组的(147.32±15.55) min、(352.10±42.14) min,差异具有统计学意义(P <0.05)。研究组患者的治疗总有效率为96.67%,显著高于对照组的73.33%,差异具有统计学意义(P <0.05)。两组患者均未发生明显不良反应。结论醒脑静、 654-2联合纳洛酮治疗重度急性酒精中毒的临床疗效确切,苏醒时间及临床症状消失时间短,无明显不良反应发生,值得临床推广。
        Objective To explore the clinical therapeutic effect of Xingnaojing, 654-2 combined with naloxone in the treatment of severe acute alcoholism. Methods 60 patients with severe acute alcoholism admitted to our hospital from January 2012 to December 2017 were selected as the research objects, and randomly divided into study group and control group, with 30 cases in each group. Patients in the control group were treated with naloxone, while patients in the study group were treated with Xingnaojing, 654-2 combined with naloxone.The disappearance time of symptoms, awakening time, clinical therapeutic effect and adverse reaction were compared between two groups.Results The awakening time and disappearance time of symptoms of the study group were(75.18 ± 10.74) min and(255.18 ± 50.72) min respectively, significantly shorter than(147.32 ± 15.55) min and(352.10 ± 42.14) min of the control group, with statistical differences(P <0.05).The total effective rate of treatment of the study group was 96.67%, significantly higher than 73.33% of the control group, with statistical difference(P <0.05). No obvious adverse reaction occurred in both groups. Conclusions Xingnaojing, 654-2 combined with naloxone in the treatment of severe acute alcoholism has definite clinical therapeutic effect, with short awakening time and disappearance time of symptoms,and no obvious adverse reactions, which is worthy of clinical promotion.

引文

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