大肠杆菌鞭毛研究进展
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摘要
<正>鞭毛是位于细菌表面的长螺旋形可旋转附属物,长约10μm,主要与细菌的运动有关。鞭毛的驱动力是许多细菌病原体的重要毒力特征,并且是建立感染所必需的。感染发生后,鞭毛有利于细菌到达侵入部位。大肠杆菌(Escherichia coli, E.coli)一般周身鞭毛,具有运动性。鞭毛蛋白,又称为H抗原,是大肠杆菌分类的重要表面抗原。本文对大肠杆菌鞭毛的结构、功能和H抗原分型作一简
引文
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[34]Mcdermott P F,Ciacciwoolwine F,Snipes J A,et al.Highaffinity interaction between gram-negative flagellin and a cell surface polypeptide results in human monocyte activation[J].Infect Immun,2000,68(10):5525-5529.
[35]Hayashi F,Means T K,Luster A D.Toll-like receptors stimulate human neutrophil function[J].Blood,2003,102(7):2660-2669.
[36]Saha S,Takeshita F,Matsuda T,et al.Blocking of the TLR5activation domain hampers protective potential of flagellin DNAvaccine[J].J Immunol,2007,179(2):1147-1154.
[37]Benyedidia T,Marcus H,Reisner Y,et al.Intranasal administration of peptide vaccine protects human/mouse radiation chimera from influenza infection[J].Int Immunol,1999,11(7):1043-1051.
[38]Liu Ge,Tarbet B,Song Lang-zhou,et al.Immunogenicity and efficacy of flagellin-fused vaccine candidates targeting 2009 pandemic H1N1 influenza in mice[J].PLo S One,2011,6(6):e20928.
[39]de Melo F M,Braga C J,Pereira F V,et al.Anti-metastatic immunotherapy based on mucosal administration of flagellin and immunomodulatory P10[J].Immunol Cell Biol,2015,93(1):86-98.
[2]张一帆,王奇,尹琳琳.少突胶质细胞与小胶质细胞的细胞间通讯研究进展[J].细胞与分子免疫学杂志,2016,32(7):990-992.
[3]Yang Ying,Yang Yi,Ou Bing-ming,et al.The flagellin hypervariable region is a potential flagella display domain in probiotic Escherichia coli strain Nissle 1917[J].Arch Microbiol,2016,198(7):1-8.
[4]Merino S,Tom?s J M.Gram-negative flagella glycosylation[J].Int J Mol Sci,2014,15(2):2840-2857.
[5]Aldridge P,Hughes K T.Regulation of flagellar assembly[J].Curr Opin Microbiol,2002,5(2):160-165.
[6]Khanra N,Rossi P,Economou A,et al.Recognition and targeting mechanisms by chaperones in flagellum assembly and operation[J].Proc Natl Acad Sci USA,2016,113(35):9798-9803.
[7]Kinoshita M,Hara N,Imada K,et al.Interactions of bacterial flagellar chaperone-substrate complexes with FlhA contribute to co ordinating assembly of the flagellar filament[J].Mol Microbiol,2013,90(6):1249-1261.
[8]Chilcott G S,Hughes K T.Coupling of flagellar gene expression to flagellar assembly in Salmonella enterica serovar typhimurium and Escherichia coli[J].Microbiol Mol Biol Rev,2000,64(4):694-708.
[9]Lee Yi-Ying,Barker C S,Matsumura P,et al.Refining the binding of the Escherichia coli flagellar master regulator,FlhD4C2,on a base-specific level[J].J Bacteriol,2011,193(16):4057.
[10]Liu Xiao-ying,Matsumura P.Differential regulation of multiple overlapping promoters in flagellar class II operons in Escherichia coli[J].Mol Microbiol,2010,21(3):613-620.
[11]Liu Xiao-ying,Matsumura P.An alternative sigma factor controls transcription of flagellar class-III operons in Escherichia coli:gene sequence,overproduction,purification and characterization[J].Gene,1995,164(1):81-84.
[12]Aldridge P D,Karlinsey J E,Aldridge C,et al.The flagellar-specific transcription factor,sigma28,is the Type III secretion chaperone for the flagellar-specific anti-sigma28 factor FlgM[J].Genes Dev,2006,20(16):2315-2326.
[13]Aldridge P,Karlinsey J,Hughes K T.The type III secretion chaperone FlgN regulates flagellar assembly via a negative feedback loop containing its chaperone substrates FlgK and FlgL[J].Mol Microbiol,2003,49(5):1333-1345.
[14]Osterman I A,Dikhtyar Y Y,Bogdanov A A,et al.Regulation of flagellar gene expression in Bacteria[J].Biochemistry,2015,80(11):1447-1456.
[15]Galeva A,Moroz N,Yoon Y H,et al.Bacterial flagellin-specific chaperone FliS interacts with anti-sigma factor FlgM[J].JBacteriol,2014,196(6):1215-1221.
[16]Fraser G M,Bennett J C Q,Hughes C.Substrate specific binding of hook associated proteins by FlgN and FliT,putative chaperones for flagellum assembly[J].Mol Microbiol,1999,32(3):569-580.
[17]Lawn A M.Comparison of the flagellins from different flagellar morphotypes of Escherichia coli[J].J Gen Microbiol,1977,101(1):112-130.
[18]He Yong-sheng,Keen J E,Westerman R B,et al.Monoclonal antibodies for detection of the H7 antigen of Escherichia coli[J].Appl Environ Microbiol,1996,62(9):3325-3332.
[19]Ratiner Y A.Different alleles of the flagellin gene hagB in Escherichia coli standard H test strains[J].FEMS Microbiol Lett,1987,48(12):97-104.
[20]周明旭.K88ac+产肠毒素大肠杆菌相关新毒力因子的研究[D].扬州:扬州大学,2016.
[21]张祥武,黄云超,雷玉洁,等.大肠杆菌鞭毛调控基因flh DC与生物材料植入感染的研究进展[J].现代生物医学进展,2015,15(12):2355-2357.
[22]Rogers T J,Paton J C,Wang H,et al.Reduced virulence of an fliC mutant of Shiga-toxigenic Escherichia coli O113:H21[J].Infect Immun,2006,74(3):1962-1966.
[23]Croxen M A,Law R J,Scholz R,et al.Recent advances in understanding enteric pathogenic Escherichia coli[J].Clin Microbiol Rev,2013,26(4):822-880.
[24]Allsopp L P,Beloin C,Ulett G C,et al.Molecular characterization of UpaB and UpaC,two new autotransporter proteins of uropathogenic Escherichia coli CFT073[J].Infect Immun,2012,80(1):321-332.
[25]Parthasarathy G,Yao Y,Kim K S.Flagella promote Escherichia coli K1 association with and invasion of human brain microvascular endothelial cells[J].Infect Immun,2007,75(6):2937-2945.
[26]Duan Qiang-de,Zhou Ming-xu,Zhu Xiao-fang,et al.Flagella from F18+Escherichia coli play a role in adhesion to pig epithelial cell lines[J].Microb Pathog,2013,55(1):32-38.
[27]Duan Qiang-de,Zhou Ming-xu,Liang Hui,et al.Contribution of flagellin subunit FliC to piglet epithelial cells invasion by F18ab E.coli[J].Vet Microbiol,2013,166(1-2):220-224.
[28]Friedlander R S,Vogel N,Aizenberg J.Role of Flagella in adhesion of Escherichia coli to abiotic surfaces[J].Langmuir,2015,31(22):6137-6144.
[29]Zhou Ming-xu,Guo Zhi-yan,Yang Yang,et al.Flagellin and F4 fimbriae have opposite effects on biofilm formation and quorum sensing in F4ac+enterotoxigenic Escherichia coli[J].Vet Microbiol,2014,168(1):148-153.
[30]Hung C,Zhou Yi-zhou,Pinkner J S,et al.Escherichia coli biofilms have an organized and complex extracellular matrix structure[J].MBio,2013,4(5):645-613.
[31]Medzhitov R,Jr J C.Innate immune recognition:mechanisms and pathways[J].Immunol Rev,2010,173(1):89-97.
[32]Sharpe A H.Mechanisms of costimulation[J].Immunol Rev,2009,229(1):5-11.
[33]Zgair A K.Escherichia coli flagellin stimulates pro-inflammatory immune response[J].World J Microb Biot,2012,28(5):2139-2146.
[34]Mcdermott P F,Ciacciwoolwine F,Snipes J A,et al.Highaffinity interaction between gram-negative flagellin and a cell surface polypeptide results in human monocyte activation[J].Infect Immun,2000,68(10):5525-5529.
[35]Hayashi F,Means T K,Luster A D.Toll-like receptors stimulate human neutrophil function[J].Blood,2003,102(7):2660-2669.
[36]Saha S,Takeshita F,Matsuda T,et al.Blocking of the TLR5activation domain hampers protective potential of flagellin DNAvaccine[J].J Immunol,2007,179(2):1147-1154.
[37]Benyedidia T,Marcus H,Reisner Y,et al.Intranasal administration of peptide vaccine protects human/mouse radiation chimera from influenza infection[J].Int Immunol,1999,11(7):1043-1051.
[38]Liu Ge,Tarbet B,Song Lang-zhou,et al.Immunogenicity and efficacy of flagellin-fused vaccine candidates targeting 2009 pandemic H1N1 influenza in mice[J].PLo S One,2011,6(6):e20928.
[39]de Melo F M,Braga C J,Pereira F V,et al.Anti-metastatic immunotherapy based on mucosal administration of flagellin and immunomodulatory P10[J].Immunol Cell Biol,2015,93(1):86-98.