参麦注射液对不稳定骨盆骨折伴失血性休克患者血流动力学及氧代谢的影响
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摘要
目的探讨参麦注射液对不稳定骨盆骨折伴失血性休克患者血流动力学及氧代谢的影响。方法将2015年7月—2018年7月于我院就诊的82例不稳定骨盆骨折伴失血性休克患者纳入研究,并用随机数据表法分成两组,对照组41例予以常规西医治疗,观察组41例在对照组的基础上予以参麦注射液。比较治疗前后血流动力学指标、氧代谢指标,并进行临床疗效评定。结果治疗后两组心率(HR)稍下降,血氧饱和度(SpO)2)、血压(BP)有所上升,观察组血流动力学指标较对照组更佳(P <0. 05);治疗后两组动脉血乳酸值、氧耗(VO)2)量下降,氧供(DO_2)升高,观察组氧代谢指标较对照组更优(P <0. 05);观察组治疗总有效率是92. 7%,高于对照组的65. 9%,差异明显(P <0. 05)。结论参麦注射液治疗不稳定骨盆骨折伴失血性休克患者的疗效突出,能明显改善血流动力学,促进氧代谢能力的恢复,提高生活质量,适合一定的临床推广。
Objective To investigate the effects of Shenmai injection on hemodynamics and oxygen metabolism in patients with unstable pelvic fracture and hemorrhagic shock. Methods 82 patients with unstable pelvic fracture accompanied by hemorrhagic shock who were treated in our hospital from July 2015 to July 2018 were included in the study. They were randomly divided into two groups: 41 patients in the control group were treated with routine western medicine,and 41 patients in the observation group were treated with Shenmai injection on the basis of the control group. The hemodynamic and oxygen metabolism indexes were compared before and after treatment,and the clinical efficacy was evaluated. Results After treatment,heart rate( HR) decreased slightly,blood oxygen saturation( SpO_2) and blood pressure( BP) increased,and hemodynamic indexes in the observation group were better than those in the control group( P < 0. 05); blood lactic acid value and oxygen consumption( VO_2) decreased,oxygen supply( DO_2) increased,oxygen metabolism index in the observation group was better than that in the control group( P < 0. 05). The total effective rate in the observation group was 92. 7%,higher than that in the control group( 65. 9%). The difference was significant( P < 0. 05). Conclusion Shenmai injection is effective in the treatment of unstable pelvic fracture with hemorrhagic shock. It can obviously improve hemodynamics,promote the recovery of oxygen metabolism and improve the quality of life,and is thus worthy of clinical promotion.
Objective To investigate the effects of Shenmai injection on hemodynamics and oxygen metabolism in patients with unstable pelvic fracture and hemorrhagic shock. Methods 82 patients with unstable pelvic fracture accompanied by hemorrhagic shock who were treated in our hospital from July 2015 to July 2018 were included in the study. They were randomly divided into two groups: 41 patients in the control group were treated with routine western medicine,and 41 patients in the observation group were treated with Shenmai injection on the basis of the control group. The hemodynamic and oxygen metabolism indexes were compared before and after treatment,and the clinical efficacy was evaluated. Results After treatment,heart rate( HR) decreased slightly,blood oxygen saturation( SpO_2) and blood pressure( BP) increased,and hemodynamic indexes in the observation group were better than those in the control group( P < 0. 05); blood lactic acid value and oxygen consumption( VO_2) decreased,oxygen supply( DO_2) increased,oxygen metabolism index in the observation group was better than that in the control group( P < 0. 05). The total effective rate in the observation group was 92. 7%,higher than that in the control group( 65. 9%). The difference was significant( P < 0. 05). Conclusion Shenmai injection is effective in the treatment of unstable pelvic fracture with hemorrhagic shock. It can obviously improve hemodynamics,promote the recovery of oxygen metabolism and improve the quality of life,and is thus worthy of clinical promotion.
引文
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[10]高海强.缺血性心肌病心力衰竭患者应用参麦注射液联合左卡尼汀治疗的效果分析[J].中国医药科学,2019,9(2):214-217.
[11]王波,王友清,毛魁,等.参麦注射液对动脉灌注化疗肝癌患者微血管密度及生存质量的影响[J].中国医药导报,2018,15(17):123-126,142.
[12]张杰,叶慧芳,单艳华.参麦注射液与无创机械通气联合持续静脉输注吗啡对急性左心功能衰竭患者动脉血气指标及BNP、NT-proBNP水平的影响[J].国际医药卫生导报,2018,24(6):833-836.
[13]张文明,王云霞.参麦注射液辅助治疗感染性休克患者疗效分析及对细胞免疫功能的影响[J].国际医药卫生导报,2017,23(20):3228-3231.
[14]冯茹,粟洋,陈咏梅.参麦注射液联合芪苈强心胶囊对老年心力衰竭患者心功能及循环内皮微粒的影响[J].临床医学工程,2017,24(11):1583-1584.
[15]杨立显.参麦注射液与羟乙基淀粉联合晶体液治疗失血性休克的对比研究[J].西部中医药,2014,27(8):84-85.
[16]张健,彭吾训.限制性液体复苏对骨盆骨折患者机体综合状态的影响[J].实用临床医药杂志,2016,20(3):127-128.
[2]张凤莲.创伤失血性休克患者的院前急救护理现状[J].中外医学研究,2018,16(19):186-188.
[3]李晓月.参麦注射液在充血性心力衰竭患者中的应用效果探究[J].中国现代药物应用,2018,12(24):91-92.
[4]潘旭东,张启锋.经皮骶髂关节空心螺钉内固定联合支架外固定在骨盆骨折中应用效果观察[J].现代诊断与治疗,2017,28(24):4680-4681.
[5]林龙波. 3D打印技术辅助复杂骨盆骨折手术治疗的可行性研究[J].现代医院,2018,18(6):883-885,890.
[6]梁伟东,李莹莹.创伤失血性休克患者成分输血的疗效观察[J].中国实用医药,2018,13(2):60-61.
[7]陈磊,于洪涛,杨智,等.限制性液体复苏在老年骨盆骨折并发失血性休克急救中的应用效果[J].中国老年学杂志,2018,38(3):609-610.
[8]刘磊,方建江,周挺.参麦注射液联合血必净对创伤失血性休克早期患者凝血功能和炎症因子的影响[J].中国生化药物杂志,2016,36(8):108-110.
[9]羊建,兰丹.参麦注射液对慢性肺源性心脏病患者血流功能状况影响的实验观察[J].中国当代医药,2017,24(24):109-111.
[10]高海强.缺血性心肌病心力衰竭患者应用参麦注射液联合左卡尼汀治疗的效果分析[J].中国医药科学,2019,9(2):214-217.
[11]王波,王友清,毛魁,等.参麦注射液对动脉灌注化疗肝癌患者微血管密度及生存质量的影响[J].中国医药导报,2018,15(17):123-126,142.
[12]张杰,叶慧芳,单艳华.参麦注射液与无创机械通气联合持续静脉输注吗啡对急性左心功能衰竭患者动脉血气指标及BNP、NT-proBNP水平的影响[J].国际医药卫生导报,2018,24(6):833-836.
[13]张文明,王云霞.参麦注射液辅助治疗感染性休克患者疗效分析及对细胞免疫功能的影响[J].国际医药卫生导报,2017,23(20):3228-3231.
[14]冯茹,粟洋,陈咏梅.参麦注射液联合芪苈强心胶囊对老年心力衰竭患者心功能及循环内皮微粒的影响[J].临床医学工程,2017,24(11):1583-1584.
[15]杨立显.参麦注射液与羟乙基淀粉联合晶体液治疗失血性休克的对比研究[J].西部中医药,2014,27(8):84-85.
[16]张健,彭吾训.限制性液体复苏对骨盆骨折患者机体综合状态的影响[J].实用临床医药杂志,2016,20(3):127-128.