淀粉纳米颗粒的制备及其作为药物载体的研究进展
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摘要
介绍了淀粉纳米颗粒的制备方法:机械研磨法、纳米沉淀法、超声波法、反相微乳液法、细乳液法、碱冷冻法、酶解回生法,阐述了其作为药物载体的应用,最后对淀粉纳米颗粒的发展前景进行展望。
The main preparation methods of starch nanoparticles in recent years are described in detail,including mechanical mill method,nano-precipitation method,ultrasonic method,reversed-phase micro-emulsion method,miniemulsion method,alkali freezing method,and enzymatic hydrolysis and starch retrogradation method. This paper expounds the applications of starch nanoparticles as a drug carrier,and points out the development prospects of starch nanoparticles.
The main preparation methods of starch nanoparticles in recent years are described in detail,including mechanical mill method,nano-precipitation method,ultrasonic method,reversed-phase micro-emulsion method,miniemulsion method,alkali freezing method,and enzymatic hydrolysis and starch retrogradation method. This paper expounds the applications of starch nanoparticles as a drug carrier,and points out the development prospects of starch nanoparticles.
引文
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[3]Lin H,Qin L Z,Hong H,et al.Preparation of starch nanoparticles via high-energy ball milling[J].Journal of Nano Research,2016,40:174-179.
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[7]Chin S F,Pang S C,Tay S H.Size controlled synthesis of starch nanoparticles by a simple nanoprecipitation method[J].Carbohydrate Polymers,2011,86(4):1817-1819.
[8]Tan Y,Xu K,Li L,et al.Fabrication of size-controlled starch-based nanospheres by nanoprecipitation[J].Acs Applied Materials&Interfaces,2009,1(4):956.
[9]Wu X,Chang Y,Fu Y,et al.Effects of non-solvent and starch solution on formation of starch nanoparticles by nanoprecipitation[J].Starch-Strke,2016,68(3/4):258-263.
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[12]Haaj S B,Magnin A,Pétrier C,et al.Starch nanoparticles formation via high power ultrasonication[J].Carbohydrate Polymers,2013,92(2):1625-1632.
[13]Chang Y,Yan X,Wang Q,et al.High efficiency and low cost preparation of size controlled starch nanoparticles through ultrasonic treatment and precipitation[J].Food Chemistry,2017,227:369-375.
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[15]Zhou G,Luo Z,Fu X.Preparation and characterization of starch nanoparticles in ionic liquid-in-oil microemulsions system[J].Industrial Crops&Products,2014,52(1):105-110.
[16]Ji G,Luo Z,Xiao Z,et al.Synthesis of starch nanoparticles in a novel microemulsion with two ILs substituting two phases[J].Journal of Materials Science,2016,51(15):7085-7092.
[17]Dziechciarek Y,van Soest J J,Philipse A P.Preparation and properties of starch-based colloidal microgels[J].Journal of Colloid&Interface Science,2002,246(1):48-59.
[18]Zhang Z,Shan H,Sun J,et al.Facile preparation of corn starch nanoparticles by alkali-freezing treatment[J].Rsc Advances,2013,3(32):13406-13411.
[19]Zhang Z,Shan H,Chen L,et al.Synthesis of p H-responsive starch nanoparticles grafted poly(L-glutamic acid)for insulin controlled release[J].European Polymer Journal,2013,49(8):2082-2091.
[20]王效金,张兆丽.马铃薯淀粉纳米颗粒与牛血清蛋白相互作用研究[J].粮食与油脂,2016,29(1):18-20.
[21]姜岁岁,杨洁,常然然,等.短直链淀粉纳米颗粒的制备及其表征[J].现代食品科技,2016,32(9):254-259.
[22]Chen X,Chen L,Yao X,et al.Dual responsive supramolecular nanogels for intracellular drug delivery[J].Chemical Communications,2014,50(29):3789-91.
[23]Kluza E,Yeo S Y,Schmid S,et al.Anti-tumor activity of liposomal glucocorticoids:The relevance of liposome-mediated drug delivery,intratumoral localization and systemic activity[J].Journal of Controlled Release,2011,151(1):10-7.
[24]Zhang A,Zhang Z,Shi F,et al.Disulfide crosslinked PEGylated starch micelles as efficient intracellular drug delivery platforms[J].Soft Matter,2013,9(7):2224-2233.
[25]Mao S,Chen J,Wei Z,et al.Intranasal administration of melatonin starch microspheres[J].International Journal of Pharmaceutics,2004,272(1):37-43.
[26]Xiao Suyao,Tong Chunyi,Liu Xuanming,et al.Preparation of folate-conjugated starch nanoparticles and its application to tumortargeted drug delivery vector[J].科学通报:英文版,2006,51(14):1693-1697.
[27]胡爱军,张志华,郑捷,等.大米纳米淀粉的超声法制备及载药性研究[J].粮食与饲料工业,2011,(8):32-35.
[28]Mahmoudi Najafi S H,Baghaie M,Ashori A.Preparation and characterization of acetylated starch nanoparticles as drug carrier:Ciprofloxacin as a model[J].International Journal of Biological Macromolecules,2016,87:48-54.
[29]Wang X.Starch nanoparticles prepared in two ionic liquids based microemulsion system and their drug loading and release properties[J].Rsc Advances,2016,6(6):4751-4757.
[30]Jain A K,Khar R K,Ahmed F J,et al.Effective insulin delivery using starch nanoparticles as a potential trans-nasal mucoadhesive carrier[J].European Journal of Pharmaceutics&Biopharmaceutics,2008,69(2):426-435.
[2]史俊丽.超微细化大米淀粉的制备和特性研究[D].武汉:华中农业大学,2005.
[3]Lin H,Qin L Z,Hong H,et al.Preparation of starch nanoparticles via high-energy ball milling[J].Journal of Nano Research,2016,40:174-179.
[4]Juna S,Huber A.Formation of nano-and micro-structures of various botanical sources of native starches investigated employing asymmetrical flow field-flow fractionation[J].Starch,2013,65(11/12):1029-1037.
[5]Ma X,Jian R,Chang P R,et al.Fabrication and characterization of citric acid-modified starch nanoparticles/plasticized-starch composites[J].Biomacromolecules,2008,9(11):3314-3320.
[6]Jongyea K,Seungtaik L.Preparation of nano-sized starch particles by complex formation with n-butanol[J].Carbohydrate Polymers,2009,76(1):110-116.
[7]Chin S F,Pang S C,Tay S H.Size controlled synthesis of starch nanoparticles by a simple nanoprecipitation method[J].Carbohydrate Polymers,2011,86(4):1817-1819.
[8]Tan Y,Xu K,Li L,et al.Fabrication of size-controlled starch-based nanospheres by nanoprecipitation[J].Acs Applied Materials&Interfaces,2009,1(4):956.
[9]Wu X,Chang Y,Fu Y,et al.Effects of non-solvent and starch solution on formation of starch nanoparticles by nanoprecipitation[J].Starch-Strke,2016,68(3/4):258-263.
[10]Qin Y,Liu C,Jiang S,et al.Characterization of starch nanoparticles prepared by nanoprecipitation:Influence of amylose content and starch type[J].Industrial Crops&Products,2016,87:182-190.
[11]蓝平,陈阿明,李冬雪,等.超声波作用对木薯淀粉化学反应性能的影响[J].食品科技,2012,37(3):246-250.
[12]Haaj S B,Magnin A,Pétrier C,et al.Starch nanoparticles formation via high power ultrasonication[J].Carbohydrate Polymers,2013,92(2):1625-1632.
[13]Chang Y,Yan X,Wang Q,et al.High efficiency and low cost preparation of size controlled starch nanoparticles through ultrasonic treatment and precipitation[J].Food Chemistry,2017,227:369-375.
[14]Gao W,Sha B,Zou W,et al.Cationic amylose-encapsulated bovine hemoglobin as a nanosized oxygen carrier[J].Biomaterials,2011,32(35):9425-33.
[15]Zhou G,Luo Z,Fu X.Preparation and characterization of starch nanoparticles in ionic liquid-in-oil microemulsions system[J].Industrial Crops&Products,2014,52(1):105-110.
[16]Ji G,Luo Z,Xiao Z,et al.Synthesis of starch nanoparticles in a novel microemulsion with two ILs substituting two phases[J].Journal of Materials Science,2016,51(15):7085-7092.
[17]Dziechciarek Y,van Soest J J,Philipse A P.Preparation and properties of starch-based colloidal microgels[J].Journal of Colloid&Interface Science,2002,246(1):48-59.
[18]Zhang Z,Shan H,Sun J,et al.Facile preparation of corn starch nanoparticles by alkali-freezing treatment[J].Rsc Advances,2013,3(32):13406-13411.
[19]Zhang Z,Shan H,Chen L,et al.Synthesis of p H-responsive starch nanoparticles grafted poly(L-glutamic acid)for insulin controlled release[J].European Polymer Journal,2013,49(8):2082-2091.
[20]王效金,张兆丽.马铃薯淀粉纳米颗粒与牛血清蛋白相互作用研究[J].粮食与油脂,2016,29(1):18-20.
[21]姜岁岁,杨洁,常然然,等.短直链淀粉纳米颗粒的制备及其表征[J].现代食品科技,2016,32(9):254-259.
[22]Chen X,Chen L,Yao X,et al.Dual responsive supramolecular nanogels for intracellular drug delivery[J].Chemical Communications,2014,50(29):3789-91.
[23]Kluza E,Yeo S Y,Schmid S,et al.Anti-tumor activity of liposomal glucocorticoids:The relevance of liposome-mediated drug delivery,intratumoral localization and systemic activity[J].Journal of Controlled Release,2011,151(1):10-7.
[24]Zhang A,Zhang Z,Shi F,et al.Disulfide crosslinked PEGylated starch micelles as efficient intracellular drug delivery platforms[J].Soft Matter,2013,9(7):2224-2233.
[25]Mao S,Chen J,Wei Z,et al.Intranasal administration of melatonin starch microspheres[J].International Journal of Pharmaceutics,2004,272(1):37-43.
[26]Xiao Suyao,Tong Chunyi,Liu Xuanming,et al.Preparation of folate-conjugated starch nanoparticles and its application to tumortargeted drug delivery vector[J].科学通报:英文版,2006,51(14):1693-1697.
[27]胡爱军,张志华,郑捷,等.大米纳米淀粉的超声法制备及载药性研究[J].粮食与饲料工业,2011,(8):32-35.
[28]Mahmoudi Najafi S H,Baghaie M,Ashori A.Preparation and characterization of acetylated starch nanoparticles as drug carrier:Ciprofloxacin as a model[J].International Journal of Biological Macromolecules,2016,87:48-54.
[29]Wang X.Starch nanoparticles prepared in two ionic liquids based microemulsion system and their drug loading and release properties[J].Rsc Advances,2016,6(6):4751-4757.
[30]Jain A K,Khar R K,Ahmed F J,et al.Effective insulin delivery using starch nanoparticles as a potential trans-nasal mucoadhesive carrier[J].European Journal of Pharmaceutics&Biopharmaceutics,2008,69(2):426-435.
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