早期与中晚期贲门腺癌患者术后预后影响因素

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英文篇名：Influencing factors of postoperation prognosis of early and advanced gastric cardiac adenocarcinoma patients 作者：韩月霞 ; 杨海军 ; 李吉林 ; 李欣然 ; 周福有 ; 鲍启德 ; 樊冰雨 ; 程锟 ; 韩雪娜 ; 王苒 ; 宋昕 ; 赵学科 ; 王立东 英文作者：HAN Yuexia;YANG Haijun;LI Jilin;LI Xinran;ZHOU Fuyou;BAO Qide;FAN Bingyu;CHENG Kun;HAN Xuena;WANG Ran;SONG Xin;ZHAO Xueke;WANG Lidong;Henan Key Laboratory of Esophageal Cancer Research,the First Affiliated Hospital,Zhengzhou University,State Key Laboratory of Esophageal Cancer Prevention and Treatment;Department of Pathology,Anyang Tumor Hospital;Department of Pathology,Linzhou Esophageal Cancer Hospital;Department of Thoracic Surgery,Anyang Tumor Hospital;Department of Oncology,Anyang Regional Hospital;Department of Pathology and Pathophysiology,School of Basic Medical Sciences,Zhengzhou University; 关键词：贲门癌 ; 术后预后 ; 影响因素 英文关键词：gastric cardia adenocarcinoma;;postoperation prognosis;;influencing factor 中文刊名：HNYK 英文刊名：Journal of Zhengzhou University(Medical Sciences) 机构：郑州大学第一附属医院河南省食管癌重点开放实验室省部共建食管癌防治国家重点实验室;安阳肿瘤医院病理科;林州市食管癌医院病理科;安阳市肿瘤医院胸外科;安阳市地区医院肿瘤科;郑州大学基础医学院病理学与病理生理学教研室; 出版日期：2019-03-22 09:00 出版单位：郑州大学学报(医学版) 年：2019 期：v.54;No.233 基金：国家自然科学基金项目(81872032,U1804262,81472323) 语种：中文; 页：HNYK201902007 页数：4 CN：02 ISSN：41-1340/R 分类号：36-39

摘要

目的:探讨早期与中晚期贲门腺癌(GCA)患者的术后预后影响因素。方法:从河南省食管癌重点开放实验室50万例食管癌和贲门癌临床信息数据库中收集5 596例GCA患者的资料。其中男4 321例,女1 275例;早、中、晚期患者分别有335、5 168和93例。患者均接受根治术治疗。结果:Cox分析结果显示,确诊年龄≥60岁(HR=3. 069,95%CI=1. 167～5. 625)、有癌栓(HR=3. 137,95%CI=1. 063～9. 253)是早期GCA患者术后预后的危险因素;男性(HR=1. 090,95%CI=1. 002～1. 185)、确诊年龄≥60岁(HR=1. 409,95%CI=1. 312～1. 531)、有癌栓(HR=1. 299,95%CI=1. 167～1. 446)、溃疡浸润型(HR=1. 260,95%CI=1. 108～1. 432)、中低分化(HR=1. 167,95%CI=1. 103～1. 344)、浸润程度深(HR=1. 502,95%CI=1. 350～1. 671)是中晚期GCA患者术后预后的危险因素。结论:确诊年龄≥60岁、有癌栓是所有病期GCA患者术后预后的独立危险因素,而男性、浸润溃疡型、低分化、浸润程度深是中晚期患者术后预后的独立危险因素。
        Aim: To investigate the influencing factors of postoperation prognosis of early and advanced gastric cardiac adenocarcinoma( GCA) patients. Methods: The data of 5 596 patients with GCA from the clinical information database of500 000 cases of esophageal and gastric cardia carcinoma of Henan key laboratory of esophageal cancer research were collected. Among them,4 321 cases were male,1 275 cases were female; 335 patients were early stage,5 168 patients were advanced stage and 93 patients were terminal stage. All the patients were treated with radical resection. Results: The Cox results showed age at diagnosis≥60 years( HR = 3. 069,95% CI = 1. 167-5. 625),and cancer thrombosis( HR = 3. 137,95% CI = 1. 063-9. 253) were independent influencing factors for prognosis of early GCA patients; male( HR = 1. 090,95% CI = 1. 002-1. 185),age at diagnosis≥60 years( HR = 1. 409,95% CI = 1. 312-1. 531),cancer thrombosis( HR =1. 299,95% CI = 1. 167-1. 446),invasive ulcer type( HR = 1. 260,95% CI = 1. 108-1. 432),median or low differentiation degree( HR = 1. 167,95% CI = 1. 103-1. 344),deep infiltration degree( HR = 1. 502,95% CI = 1. 350-1. 167) were independent influencing factors for prognosis of patients with advanced GCA. Conclusion: Age at diagnosis≥60 years and cancer thrombosis are independent risk factors for GCA prognosis; male,invasive ulcer type,poor differentiation and deep infiltration degree are only independent risk factors for the patients with advanced GCA.

引文

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