肿瘤家族史对贲门腺癌患者术后预后的影响

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英文篇名：Influence of tumor family history on postoperation prognosis of patients with gastric cardia adenocarcinoma 作者：雷玲玲 ; 王献增 ; 魏锦昌 ; 程锟 ; 李吉林 ; 周福有 ; 韩月霞 ; 李欣然 ; 赵学科 ; 李贝 ; 宋昕 ; 王建坡 ; 王立东 英文作者：LEI Lingling;WANG Xianzeng;WEI Jinchang;CHENG Kun;LI Jilin;ZHOU Fuyou;HAN Yuexia;LI Xinran;ZHAO Xueke;LI Bei;SONG Xin;WANG Jianpo;WANG Lidong;Department of Pathology and Pathophysiology,School of Basic Medical Sciences,Zhengzhou University;Henan Key Laboratory of Esophageal Cancer Research,the First Affiliated Hospital,Zhengzhou University, State Key Laboratory of Esophageal Cancer Prevention and Treatment;Department of Thoracic Surgery,Linzhou People' s Hospital;Department of Thoracic Surgery,Linzhou Esophageal Cancer Hospital;Department of Pathology,Linzhou Esophageal Cancer Hospital;Department of Thoracic Surgery,Anyang Tumor Hospital;Prevention and Control office,Anyang Tumor Hospital; 关键词：贲门腺癌 ; 高低发区 ; 肿瘤家族史 ; 术后预后 英文关键词：gastric cardia adenocarcinoma;;high-and low-incidence area;;tumor family history;;postoperation prognosis 中文刊名：HNYK 英文刊名：Journal of Zhengzhou University(Medical Sciences) 机构：郑州大学基础医学院病理学与病理生理学教研室;郑州大学第一附属医院河南省食管癌重点开放实验室省部共建食管癌防治国家重点实验室;林州市人民医院胸外科;林州市食管癌医院胸外科;林州市食管癌医院病理科;安阳市肿瘤医院胸外科;安阳市肿瘤医院防治办公室; 出版日期：2019-03-22 09:00 出版单位：郑州大学学报(医学版) 年：2019 期：v.54;No.233 基金：国家自然科学基金项目(81872032,U1804262);; 河南省科技重大专项(161100311300) 语种：中文; 页：HNYK201902006 页数：4 CN：02 ISSN：41-1340/R 分类号：32-35

摘要

目的:探讨肿瘤家族史对贲门腺癌(GCA)患者术后预后的影响。方法:3 088例接受根治术治疗的GCA患者的临床、病理和随访信息取自河南省食管癌重点开放实验室50万例食管癌和贲门癌临床信息数据库。高发区2 315例,低发区773例。结果:在高发区,家族史阴性和阳性患者肿瘤长径、分化程度差异有统计学意义(P <0. 05);在低发区,家族史阴性和阳性患者肿瘤长径差异有统计学意义(P <0. 05)。Cox回归分析结果显示,肿瘤家族史阳性是低发区GCA患者术后预后的独立保护因素[HR(95%CI)=1. 338(1. 084～1. 651)]。结论:低发区肿瘤家族史可能是GCA患者术后预后的独立影响因素。
        Aim: To explore the effects of tumor family history on the postoperation prognosis of patients with gastric cardia adenocarcinoma( GCA) in high-and low-incidence areas. Methods: The clinical,pathological and follow-up information of 3 088 patients with GCA treated by radical resection was collected from the clinical information database of 500 000 cases of esophageal and gastric cardia carcinoma of Henan key laboratory of esophageal cancer research. A total of 2 315 patients were from the high-incidence area,and 773 from the low-incidence area. Results: There were statistical differences in tumor long diameter,differentiation degree between the pateints with positive and negative family history from the high-incidence area( P < 0. 05),and in tumor long diameter between the pateints with positive and negative family history from the low-incidence area( P < 0. 05). Cox analysis showed that family history was an independent factor affecting the postoperation prognosis of GCA patients from low-incidence area,and HR( 95% CI) = 1. 338( 1. 084-1.651). Conclusion: Family history of tumor in low-incidence area may be an independent factor affecting the postoperation prognosis of patients with GCA.

引文

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