肿瘤最长直径对贲门腺癌患者术后预后判定的价值
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摘要
目的:探讨肿瘤最长直径(MTD)判断贲门腺癌(GCA)患者术后预后的价值。方法:4 347例GCA患者基本信息、随访记录均来自河南省食管癌重点开放实验室50万例食管癌和贲门癌临床信息数据库,MTD与TNM分期等临床病理资料来自医院病历记录。结果:低发区、TNM晚期GCA患者MTD大于高发区或TNM早期患者(P <0. 05)。Cox回归分析结果显示,MTD较大是GCA患者术后预后的独立危险因素,HR(95%CI)=1. 163 (1. 084～1. 248)。结论:MTD可为GCA的预后评估提供参考。
Aim: To investigate the value of maximum tumor diameter( MTD) in judging the prognosis of patients with gastric cardia adenocarcinoma( GCA). Methods: Basic clinical and follow-up information of 4 347 patients with GCA were collected from the clinical information database of 500 000 cases of esophageal and gastric cardia carcinoma of Henan key laboratory of esophageal cancer research. The clinical and pathological records such as MTD and TNM stages was obtained from the medical records of the hospital. Results: MTD of the patients from high-incidence area or with high TNM stage was higher than those of the patients from low-incidence area or with low TNM stage( P < 0. 05). The results of Cox regression analysis showed that high MTD was independent risk factor for the postoperation prognosis of GCA,and HR( 95% CI)was 1. 163( 1. 084-1. 248). Conclusion: MTD should be included in TNM pathological staging criteria of gastric cardia adenocarcinoma to provide reference for assessment of postoperation prognosis.
Aim: To investigate the value of maximum tumor diameter( MTD) in judging the prognosis of patients with gastric cardia adenocarcinoma( GCA). Methods: Basic clinical and follow-up information of 4 347 patients with GCA were collected from the clinical information database of 500 000 cases of esophageal and gastric cardia carcinoma of Henan key laboratory of esophageal cancer research. The clinical and pathological records such as MTD and TNM stages was obtained from the medical records of the hospital. Results: MTD of the patients from high-incidence area or with high TNM stage was higher than those of the patients from low-incidence area or with low TNM stage( P < 0. 05). The results of Cox regression analysis showed that high MTD was independent risk factor for the postoperation prognosis of GCA,and HR( 95% CI)was 1. 163( 1. 084-1. 248). Conclusion: MTD should be included in TNM pathological staging criteria of gastric cardia adenocarcinoma to provide reference for assessment of postoperation prognosis.
引文
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[16]王占东,杨杰,陈砚凝,等.食管胃交界腺癌的病理特征及预后分析[J].山东医药,2010,50(26):19
[2]陈志峰,侯浚,贺宇彤,等.食管胃交界腺癌-肿瘤登记面临的新课题[J].中国肿瘤临床,2007,34(24):1381
[3]MONTAL R,OLIVA M,TABERNA M,et al.Residual neck disease management in squamous-cell carcinoma of the head and neck treated with radiotherapy plus cetuximab[J].Clin Transl Oncol,2016,18(11):1140
[4]祝淑钗,李任,李娟,等.非手术治疗胸段食管癌临床分期与预后关系的初步探讨[J].中华放射肿瘤学杂志,2004,13(3):49
[5]陈志峰,宋国慧,侯浚,等.磁县1988~2007年食管癌和贲门癌发病分析[J].中国肿瘤,2011,20(4):262
[6]王立东,郑树.河南食管癌高发区人群食管和贲门癌变机制[J].郑州大学学报(医学版),2002,47(6):717
[7]陈曦,范宗民,蔺红丽,等.贲门癌瘤体最长直径与临床病理特征的关系及其对患者生存期的影响[J].肿瘤防治研究,2014,41(3):209
[8]WANG BY,GOAN YG,HSU PK,et al.Tumor length as a prognostic factor in esophageal squamous cell carcinoma[J].Ann Thorac Surg,2011,91(3):887
[9]申秋,王立东,常扶保,等.食管癌和贲门癌手术切除标本离体前后及固定后的收缩变化[J].郑州大学学报(医学版),2009,44(1):37
[10]河南医学院.食管癌[M].北京:人民卫生出版社,1983:36
[11]孙斌,杨林.超声内镜在食管癌分期及治疗评价中的应用[J].安徽医药,2018,22(4):599
[12]GRIFFITHS EA,BRUMMELL Z,GORTHI G,et al.Tumor length as a prognostic factor in esophageal malignancy:univariate and multivariatesurvival analyses[J].J Surg Oncol,2006,93(4):258
[13]ARIGAMI T,UCHIKADO Y,OMOTO I,et al.Primary tumor score based on tumor depth and length predicts prognosis in esophageal squamous cell carcinoma[J].Anticancer Res,2018,38(9):544
[14]ZHANG HJ,BI LW,ZHANG LZ,et al.Prognostic value of tumor length in predicting survival for patients with esophageal cancer[J].Trans Can Res,2018,7(3):506
[15]WU J,CHEN QX.Prognostic and predictive significance of tumor length in patients with esophageal squamous cell carcinoma undergoing radical resection[J].BMC Cancer,2016,16:394
[16]王占东,杨杰,陈砚凝,等.食管胃交界腺癌的病理特征及预后分析[J].山东医药,2010,50(26):19
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