食管癌核心家系患者临床病理特征及术后预后分析

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英文篇名：Analysis of clinicopathological features and postoperation prognosis of patients from core family of esophageal cancer 作者：澹会芳 ; 赵学科 ; 高社干 ; 韩文莉 ; 鲍启德 ; 韩雪娜 ; 雷玲玲 ; 徐瑞华 ; 王盼盼 ; 李贝 ; 宋昕 ; 王建坡 ; 王立东 英文作者：TAN Huifang;ZHAO Xueke;GAO Shegan;HAN Wenli;BAO Qide;HAN Xuena;LEI Lingling;XU Ruihua;WANG Panpan;LI Bei;SONG Xin;WANG Jianpo;WANG Lidong;Henan Key Laboratory of Esophageal Cancer Research,the First Affiliated Hospital,Zhengzhou University, State Key Laboratory of Esophageal Cancer Prevention and Treatment;Department of Oncology,the First Affiliated Hospital,Henan University of Science and Technology;Department of Pathology and Pathophysiology,School of Basic Medical Sciences,Zhengzhou University;Department of Oncology,Anyang Regional Hospital;Oncology Prevention Office,Anyang Tumor Hospital; 关键词：食管癌 ; 核心家系 ; 临床病理特征 ; 预后 英文关键词：esophageal cancer;;core family;;clinicopathological features;;prognosis 中文刊名：HNYK 英文刊名：Journal of Zhengzhou University(Medical Sciences) 机构：郑州大学第一附属医院河南省食管癌重点开放实验室省部共建食管癌防治国家重点实验室;河南科技大学第一附属医院肿瘤科;郑州大学基础医学院病理学与病理生理学教研室;安阳市地区医院肿瘤科;安阳市肿瘤医院肿瘤防治办公室; 出版日期：2019-03-22 09:00 出版单位：郑州大学学报(医学版) 年：2019 期：v.54;No.233 基金：国家自然科学基金项目(81872032,U1804262);; 国家科技部重点研发计划"精准医学研究"重点专项(2016YFC0901403) 语种：中文; 页：HNYK201902003 页数：5 CN：02 ISSN：41-1340/R 分类号：21-25

摘要

目的:分析食管癌核心家系患者的临床病理特征及术后预后影响因素。方法:收集3 260例接受食管癌根治性切除手术的、来自于不同食管癌核心家系的患者的临床病理资料和随访信息,分析食管癌核心家系患者的临床病理特征及术后预后影响因素。结果:3 260例食管鳞癌患者男女比例为1. 7∶1,确诊年龄32～85(60. 2±8. 1)岁,≥60岁者占53. 8%; 88. 8%来自食管癌高发区;肿瘤位于食管中段和下段者占82. 5%;低、中、高分化者分别占26. 6%、61. 9%和11. 5%;切缘净占94. 3%;肿瘤长径<4 cm者占47. 6%; TNM分期(0+Ⅰ)期占15. 2%,Ⅱ、Ⅲ、Ⅳ期者分别占54. 5%、29. 9%和0. 4%。Cox分析结果显示,男性、确诊年龄≥60岁、肿瘤位于食管颈段和上段、分化程度低、肿瘤长径≥4 cm和TNM晚期是食管癌核心家系患者术后预后的独立危险因素,HR(95%CI)分别为1. 119(1. 016～1. 231)、1. 302 (1. 185～1. 429)、1. 345 (1. 186～1. 526)、1. 149 (1. 065～1. 238)、1. 269 (1. 151～1. 400)、1. 666(1. 547～1. 795)。结论:性别、确诊年龄、肿瘤部位、分化程度、肿瘤长径及TNM分期是食管癌核心家系患者术后预后的影响因素。
        Aim: To analyze the clinicopathological features and postoperation prognosis of patients from core family of esophageal cancer. Methods: The clinical pathological data and follow-up information of 3 260 esophageal squamous cell carcinoma( ESCC) patients from different core families and undergoing radical resection of esophageal cancer were collected,and the clinicopathological features and prognosis were retrospectively analyzed. Results: Among the 3 260 patients,the ratio of men to women was 1. 7∶ 1,the age at diagnosis was 32-85( 60. 2 ± 8. 1) years,53. 8% patients was more than60 years old; 88. 8% came from the high-incidence area; 26. 6%,61. 9% and 11. 5% were with low,medium,and high differentiation,respectively; 94. 3% had postoperative margin clearance; the patients with tumor long diameter < 4 cm accounted for 47. 6%; the proportion of the patients with TNM 0 + Ⅰ,Ⅱ,Ⅲ,Ⅳ stage were 15. 2%,54. 5%,29. 9% and 0. 4%,respectively. The results of Cox regression showed that males,age at diagnosis≥60 years,tumor segment + upper segment,low degree of differentiation,tumor long diameter ≥4 cm and late TNM stage were the risk factors for the postoperation prognosis,and HR( 95% CI) was 1. 119( 1. 016-1. 231),1. 302( 1. 185-1. 429),1. 345( 1. 186-1. 526),1. 149( 1. 065-1. 238),1. 269( 1. 151-1. 400),1. 666( 1. 547-1. 795),respectively. Conclusion: Gender,age at diagnosis,location of tumor,degree of differentiation,length of tumor,and TNM stage may be the influencing factors of postoperation prognosis for ESCC patients from esophageal cancer core family.

引文

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