蜡梅属植物中黄酮和香豆素类成分及药理活性研究进展
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摘要
蜡梅属植物为中国特有,分布广泛、资源丰富,其根、茎、叶、花蕾和果均可入药,是传统的庭园观赏植物和民间药用植物,具有巨大的开发前景。对近年来蜡梅属植物中黄酮和香豆素类成分及其药理活性的最新研究进展进行归纳总结,以期为蜡梅属植物的进一步研究与开发提供参考。
Chimonanthus plants are endemic in China, which was rich and widely distributed; And its roots, stems, leaves, buds, and fruit can be used as medicine. It is a traditional garden flower and folk medicine, which has a great prospect for development. In this paper, the constituents flavonoids and coumarins from the genus Chimonanthus plants and its pharmacological activities were systematically reviewed, and their research status and development prospects were prospected to provide reference for the further research and development of Chimonanthus plants.
Chimonanthus plants are endemic in China, which was rich and widely distributed; And its roots, stems, leaves, buds, and fruit can be used as medicine. It is a traditional garden flower and folk medicine, which has a great prospect for development. In this paper, the constituents flavonoids and coumarins from the genus Chimonanthus plants and its pharmacological activities were systematically reviewed, and their research status and development prospects were prospected to provide reference for the further research and development of Chimonanthus plants.
引文
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[7]Chen H,Ouyang K,Jiang Y,et al.Constituent analysis of the ethanol extracts of Chimonanthus nitens Oliv.leaves and their inhibitory effect onα-glucosidase activity[J].Int J Biol Macromol,2017,98:829-836.
[8]Zhang S,Zhang H,Chen L,et al.Phytochemical profiles and antioxidant activities of different varieties of Chimonanthus praecox[J].Ind Crops Prod,2016,85:11-21.
[9]夏玮,古丽加玛丽·阿比斯,潘晨,等.蜡梅花中黄酮类化合物的UHPLC/QTOF-MS分析[J].中成药,2014,36(11):2345-2349.
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[11]Chen H,Jiang Y,Yang Z,et al.Effects of Chimonanthus nitens Oliv.leaf extract on glycolipid metabolism and antioxidant capacity in diabetic model mice[J].Oxid Med Cell Long,2017,2017(8):1-11.
[12]Venugopala K N,Rashmi V,Odhav B.Review on natural coumarin lead compounds for their pharmacological activity[J].Biomed Res Int,2013,2013(3):1-14.
[13]Wang K W,Li D,Wu B,et al.New cytotoxic dimeric and trimeric coumarins from Chimonanthus salicifolius[J].Phytochem Lett,2016,16:115-120.
[14]Tan T,Lou Y,Zhong C C,et al.Comprehensive profiling and characterization of coumarins fromroots,stems,leaves,branches,and seeds of Chimonanthus nitens Oliv.using ultra-performance liquid chromatography/quadrupole-time-of-flight mass spectrometrycombined with modified mass defect filter[J].J Pharm Biomed Anal,2017,141:140-148.
[15]Li Q J,Wang M L,Yang X S,et al.Two new coumarin glycosides from Chimonanthus nitens[J].J Asian NatProd Res,2013,15(3):270-275.
[16]毕武,姚霞,何春年,等.香风茶的传统应用与研究现状[J].中国现代中药,2013,15(11):1012-1018.
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[19]刘易鑫,颜日明,鲁顺保,等.突托蜡梅叶中挥发油成分及其抑菌活性研究[J].中国中药杂志,2011,36(22):3149-3154.
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[22]周婧,钱超,宋莹莹,等.野生柳叶蜡梅叶挥发油成分的GC-MS分析及其抗氧化活性[J].华西药学杂志,2013,28(3):238-240.
[23]耿敬章.柳叶蜡梅叶总黄酮超声波协同复合酶提取及抗氧化活性研究[J].食品工业科技,2016,37(21):124-129.
[24]温慧萍,费俭,童应鹏.畲药柳叶蜡梅止泻作用的初步探讨[J].中华中医药学刊,2013,43(1):62-63.
[25]Wang W X,Cao L,Xiong J,et al.Constituents from Chimonanthus praecox(wintersweet)[J].Phytochem Lett,2011,4(3):271-274.
[26]王胜,周静,代时宇,等.蜡梅叶总黄酮对小鼠心肌缺血损伤的保护作用[J].湖北中医杂志,2014,36(1):4-5.
[27]Zhou X,Yang Y,Zhou C,et al.Anti-depression effect of Chimonanthus salicifolicus essential oil in chronic stressed rats[J].J Med Plant Res,2014,8(10):430-435.
[2]郭赋英,曾文文,楼浙辉.江西省蜡梅属(Chimonanthus)种质资源及利用[J].南方林业科学,2011(5):15-16.
[3]涂昆,邹峥嵘.蜡梅属植物生物碱的生物活性和合成研究进展[J].中草药,2017,48(11):2340-2352.
[4]杜裕芳,陈海芳,冯育林,等.蜡梅属植物的化学成分及药理作用研究进展[J].时珍国医国药,2013,24(8):1981-1983.
[5]王凌云,张志斌,邹峥嵘,等.蜡梅属植物化学成分和药理活性研究进展[J].时珍国医国药,2012,23(12):3103-3106.
[6]Zhang X,Xu M,Zhang J,et al.Identification and evaluation of antioxidant components in the flowers of five Chimonanthus species[J].Ind Crops Prod,2017,102:164-172.
[7]Chen H,Ouyang K,Jiang Y,et al.Constituent analysis of the ethanol extracts of Chimonanthus nitens Oliv.leaves and their inhibitory effect onα-glucosidase activity[J].Int J Biol Macromol,2017,98:829-836.
[8]Zhang S,Zhang H,Chen L,et al.Phytochemical profiles and antioxidant activities of different varieties of Chimonanthus praecox[J].Ind Crops Prod,2016,85:11-21.
[9]夏玮,古丽加玛丽·阿比斯,潘晨,等.蜡梅花中黄酮类化合物的UHPLC/QTOF-MS分析[J].中成药,2014,36(11):2345-2349.
[10]Sun Q,Zhu J,Cao F,et al.Anti-inflammatory properties of extracts from Chimonanthus nitens Oliv.leaf[J].PLo SOne,2017,12(7):1-19.
[11]Chen H,Jiang Y,Yang Z,et al.Effects of Chimonanthus nitens Oliv.leaf extract on glycolipid metabolism and antioxidant capacity in diabetic model mice[J].Oxid Med Cell Long,2017,2017(8):1-11.
[12]Venugopala K N,Rashmi V,Odhav B.Review on natural coumarin lead compounds for their pharmacological activity[J].Biomed Res Int,2013,2013(3):1-14.
[13]Wang K W,Li D,Wu B,et al.New cytotoxic dimeric and trimeric coumarins from Chimonanthus salicifolius[J].Phytochem Lett,2016,16:115-120.
[14]Tan T,Lou Y,Zhong C C,et al.Comprehensive profiling and characterization of coumarins fromroots,stems,leaves,branches,and seeds of Chimonanthus nitens Oliv.using ultra-performance liquid chromatography/quadrupole-time-of-flight mass spectrometrycombined with modified mass defect filter[J].J Pharm Biomed Anal,2017,141:140-148.
[15]Li Q J,Wang M L,Yang X S,et al.Two new coumarin glycosides from Chimonanthus nitens[J].J Asian NatProd Res,2013,15(3):270-275.
[16]毕武,姚霞,何春年,等.香风茶的传统应用与研究现状[J].中国现代中药,2013,15(11):1012-1018.
[17]Zhang J W,Gao J M,Tian X,et al.Antifungal activity of alkaloids from the seeds of Chimonanthus praecox[J].Chem Biodiv,2009,6(6):838-845.
[18]刘祝祥,贺建武,彭德娇,等.蜡梅叶挥发性成分及其抑菌活性研究[J].湖南农业科学,2011(1):75-77.
[19]刘易鑫,颜日明,鲁顺保,等.突托蜡梅叶中挥发油成分及其抑菌活性研究[J].中国中药杂志,2011,36(22):3149-3154.
[20]Liu Z,Xi J,Wang W,et al.Chimonanthus nitens var.salicifolius aqueous extract protects against 5-fluorouracil induced gastrointestinal mucositis in a mouse model[J].Evid-Based Compl Altern Med,2013,2013:1-12.
[21]潘心禾,史小娟,张新凤,等.柳叶蜡梅化学成分及其抗氧化活性研究[J].中国实验方剂学杂志,2012,18(1):99-102.
[22]周婧,钱超,宋莹莹,等.野生柳叶蜡梅叶挥发油成分的GC-MS分析及其抗氧化活性[J].华西药学杂志,2013,28(3):238-240.
[23]耿敬章.柳叶蜡梅叶总黄酮超声波协同复合酶提取及抗氧化活性研究[J].食品工业科技,2016,37(21):124-129.
[24]温慧萍,费俭,童应鹏.畲药柳叶蜡梅止泻作用的初步探讨[J].中华中医药学刊,2013,43(1):62-63.
[25]Wang W X,Cao L,Xiong J,et al.Constituents from Chimonanthus praecox(wintersweet)[J].Phytochem Lett,2011,4(3):271-274.
[26]王胜,周静,代时宇,等.蜡梅叶总黄酮对小鼠心肌缺血损伤的保护作用[J].湖北中医杂志,2014,36(1):4-5.
[27]Zhou X,Yang Y,Zhou C,et al.Anti-depression effect of Chimonanthus salicifolicus essential oil in chronic stressed rats[J].J Med Plant Res,2014,8(10):430-435.