承德地区13120例女性生殖道HPV感染结果分析
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摘要
目的:分析河北省承德地区女性人乳头瘤病毒(HPV)感染的基因型别分布和年龄分布特征。方法:在承德医学院附属医院进行HPV感染检测的女性13120例,用人乳头瘤病毒核酸分型检测试剂盒检测HPV的基因型别,并分析年龄分布等特征。结果:13120例女性HPV感染率为32.30%(4238/13120);27种基因亚型均有检出,以16型最多,其次为58型、52型、6型。4238例感染者中,高危型、低危型、混合感染构成比分别为60.85%、19.58%、19.56%,单一型、两重感染、多种感染的构成比分别为64.51%、22.18%、13.31%。年龄分布分析结果显示,感染率居前3位的年龄段是≤20岁、20～24岁,60～64岁。结论:河北省承德地区女性HPV感染主要以高危型、单一感染为主,感染率较高的基因型别是16型、58型、52型、6型,且随年龄呈U形分布。
Objective: To analyze the genotype distribution and age distribution of human papillomavirus(HPV infection of female in Hebei Chengde. Methods: Human papillomavirus nucleic acid typing detection kit was used to detect HPV infection of 13120 female in the Affiliated Hospital of Chengde Medical College, and the genotype distribution and age distribution of HPV infection were analyzed. Results: The HPV infection rate in 13120 female was 32.30%(4238/13120);27 genotypes were detected, among which 16 genotype was the most, followed by 58, 52 and 6 genotype. In 4238 female,the constituent ratio of high-risk infection, low-risk infection and mixed infection were respectively 60.85%, 19.58% and19.56%; the constituent ratio of single infection, double infection and multiple infection were respectivly 64.51%, 22.18%and 13.31%. The top three age groups of HPV infection rate were lower than 20 years old, 20-24 years old and 60-64 years old. Conclusions: The female HPV infection in Hebei Chengde area is mainly high-risk type and single infection, the genotypes with high infection rate were 16, 58, 52 and 6, and the distribution is U-shaped with age.
Objective: To analyze the genotype distribution and age distribution of human papillomavirus(HPV infection of female in Hebei Chengde. Methods: Human papillomavirus nucleic acid typing detection kit was used to detect HPV infection of 13120 female in the Affiliated Hospital of Chengde Medical College, and the genotype distribution and age distribution of HPV infection were analyzed. Results: The HPV infection rate in 13120 female was 32.30%(4238/13120);27 genotypes were detected, among which 16 genotype was the most, followed by 58, 52 and 6 genotype. In 4238 female,the constituent ratio of high-risk infection, low-risk infection and mixed infection were respectively 60.85%, 19.58% and19.56%; the constituent ratio of single infection, double infection and multiple infection were respectivly 64.51%, 22.18%and 13.31%. The top three age groups of HPV infection rate were lower than 20 years old, 20-24 years old and 60-64 years old. Conclusions: The female HPV infection in Hebei Chengde area is mainly high-risk type and single infection, the genotypes with high infection rate were 16, 58, 52 and 6, and the distribution is U-shaped with age.
引文
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[2]Demir F,Kimiloglu E,Igdem AA,et al.High risk HPV in situ hybridization,p16 INK 4A,and survivin expressions in cervical carinomas and intraepithelial neoplasms evaluation of prognostic factors[J].Eur J Gynaecol Oncol,2014,35(6):708-717.
[3]Pierce Campbell CM,Menezes LJ,Paskett ED,et al.Prevention of invasive cervical cancer in the United States:past,present,and future[J].Cancer Epidemiol Biomarker Pre,2012,21(9):1402-1408.
[4]李利平,苏鲁贤,吴成勇,等.梅州市客家妇女感染人HPV类型分析[J].河北医学,2011,17(12):1626-1630.
[5]Shah SS,Senapati S,Klacsmann F,et al.Current Technologies and Recent Developments for Screening of HPV-Associated Cervical and Oropharyngeal Cancers[J].Cancers(Basel),2016,8(9):pii:E85.
[6]赵健,杨英捷,廖秦平.导流杂交基因芯片技术在人乳头状瘤病毒感染分型检测中的临床应用[J].中华检验医学杂志,2006,29(12):1418-1151.
[7]聂妹芳,李登清,黄民主,等.11461例妇科门诊患者HPV亚型感染状况的研究[J].中国现代医学杂志,2011,21(27):3434-3438.
[8]李翀,郑旭.天津地区4232例妇女宫颈HPV感染基因谱分析[J].中国妇幼保健,2015,30(10):1571-1573.
[9]李永川,徐含青,赵娜,等.重庆地区32882例女性宫颈人乳头瘤病毒的感染状况调查[J].第三军医大学学报,2016,38(9):1031-1034.
[10]陈捷,张璇.福州地区妇女宫颈人乳头瘤病毒感染流行病学调查分析[J].福建医药杂志,2017,39(2):129-131.
[11]彭园园,赵丽娟,高虹,等.石家庄地区5092例女性HPV感染基因型分型[J].中华实验和临床病毒学杂志,2015,29(4):289-291.
[12]廖光东,张小燕,高玉华,等.流式荧光杂交法检测高危型人乳头瘤病毒的临床验证试验[J].中国医学科学院学报,2007,29(5):603-607.
[13]何桂荣,武学成.深圳地区女性感染人乳头瘤病毒基因类型分析[J].现代检验医学杂志,2007,22(2):19-21.